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Literature summary for 5.6.2.2 extracted from

  • Park, H.J.; Lee, H.J.; Lee, E.J.; Hwang, H.J.; Shin, S.H.; Suh, M.E.; Kim, C.; Kim, H.J.; Seo, E.K.; Lee, S.K.
    Cytotoxicity and DNA topoisomerase inhibitory activity of benz[f]indole-4,9-dione analogs (2003), Biosci. Biotechnol. Biochem., 67, 1944-1949.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
1-ethoxycarbonyl-naphthoquinone-[2,3-d]indolizidine-6,11-dione 0.1 mg/ml, 32.1% inhibition of relaxation Homo sapiens
2-Amino-1-(1-benzyl-piperidin-4-yl)-4,9-dioxo-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 17.0% inhibition of relaxation Homo sapiens
2-Amino-1-(2-bromo-ethyl)-4,9-dioxo-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 43.4% inhibition of relaxation Homo sapiens
2-Amino-1-(2-hydroxy-ethyl)-4,9-dioxo-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 7.8% inhibition of relaxation Homo sapiens
2-Amino-1-(4-amino-phenyl)-4,9-dioxo-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 7.8% inhibition of relaxation Homo sapiens
2-Amino-1-(4-fluoro-phenyl)-4,9-dioxo-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 28.3% inhibition of relaxation Homo sapiens
2-Amino-1-benzyl-4,9-dioxo-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 9.4% inhibition of relaxation Homo sapiens
2-Amino-1-cyclohexyl-4,9-dioxo-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 7.8% inhibition of relaxation Homo sapiens
2-Amino-1-isopropyl-4,9-dioxo-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 5.9% inhibition of relaxation Homo sapiens
2-amino-3-ethoxycarbonyl-N-(4-fluorophenyl)benz[f]indole-4,9-dione potent inhibitor Homo sapiens
2-amino-3-ethoxycarbonyl-N-methyl-benz[f]indole-4,9-dione 0.1 mg/ml, 9.8% inhibition of relaxation Homo sapiens
2-Amino-4,9-dioxo-1-p-tolyl-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 41.2% inhibition of relaxation Homo sapiens
2-Amino-4,9-dioxo-1-phenyl-3a,4,9,9a-tetrahydro-1H-benzo[f]indole-3-carboxylic acid ethyl ester 0.1 mg/ml, 21.6% inhibition of relaxation Homo sapiens
2-hydroxy-3-ethoxycarbonyl-N-(3,4-dimethylphenyl)-benz[f]indole-4,9-dione 0.1 mg/ml, 17.0% inhibition of relaxation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
negatively supercoiled pHOTI plasmid DNA + ATP + H2O
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 Homo sapiens ?
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 ?