Literature summary for 5.6.2.2 extracted from

Mizushina, Y.; Ikuta, A.; Endoh, K.; Oshige, M.; Kasai, N.; Kamiya, K.; Satake, T.; Takazawa, H.; Morita, H.; Tomiyasu, H.; Yoshida, H.; Sugawara, F.; Sakaguchi, K.
Inhibition of DNA polymerases and DNA topoisomerase II by triterpenes produced by plant callus (2003), Biochem. Biophys. Res. Commun., 305, 365-373.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3alpha-corosolic acid	IC50: 0.083 mM; IC50: 0.089 mM	Homo sapiens
3beta-corosolic acid	IC50: 0.049 mM	Homo sapiens
betulinic acid	IC50: 0.08 mM	Homo sapiens
corosolic acid	IC50: 0.043 mM	Homo sapiens
maslinic acid	IC50: 0.092 mM	Homo sapiens
oleanolic acid	IC50: 0.081 mM	Homo sapiens
ursolic acid	IC50: 0.036 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	topoisomerase IIalpha	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0108	-	ursolic acid	-	Homo sapiens
0.0494	-	3beta-corosolic acid	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.036	-	IC50: 0.036 mM	Homo sapiens	ursolic acid
0.043	-	IC50: 0.043 mM	Homo sapiens	corosolic acid
0.049	-	IC50: 0.049 mM	Homo sapiens	3beta-corosolic acid
0.08	-	IC50: 0.08 mM	Homo sapiens	betulinic acid
0.081	-	IC50: 0.081 mM	Homo sapiens	oleanolic acid
0.083	-	IC50: 0.083 mM	Homo sapiens	3alpha-corosolic acid
0.089	-	IC50: 0.089 mM	Homo sapiens	3alpha-corosolic acid
0.092	-	IC50: 0.092 mM	Homo sapiens	maslinic acid

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Release 2023.1 (January 2023)