Literature summary for 5.6.2.2 extracted from

Zhang, Y.L.; Shen, Y.C.; Wang, Z.Q.; Chen, H.X.; Guo, X.; Cheng, Y.C.; Lee, K.H.
Antitumor agents, 130, novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II (1992), J. Nat. Prod., 55, 1100-1111.

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Inhibitors

Inhibitors	Comment	Organism	Structure
o-Quinone analogues of podophyllotoxin possessing various C-4 beta-aniline moieties	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
network of DNA rings + ATP + H2O	decatenation	Homo sapiens	monomeric DNA circles + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	catenation	Homo sapiens	catenated DNA networks + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	relaxation	Homo sapiens	relaxed DNA + ADP + phosphate	-	?

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Release 2023.1 (January 2023)