Literature summary for 5.6.2.2 extracted from

Tepe, J.J.; Madalengoitia, J.S.; Slunt, K.M.; Werbovetz, K.W.; Spoors, P.G.; Macdonald, T.L.
Inhibition of DNA topoisomerase II by azaelliptitoxins functionalized in the variable substituent domain (1996), J. Med. Chem., 39, 2188-2196.

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Inhibitors

Inhibitors	Comment	Organism	Structure
11-(4-Cyanoanilino)azatoxin	-	Homo sapiens
C11-substituted derivatives of azaelliptitoxin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
network of DNA rings + ATP + H2O	decatenation	Homo sapiens	monomeric DNA circles + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	catenation	Homo sapiens	catenated DNA networks + ADP + phosphate	-	?
supercoiled DNA + ATP + H2O	relaxation	Homo sapiens	relaxed DNA + ADP + phosphate	-	?

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Release 2023.1 (January 2023)