Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.2 extracted from

  • Sullivan, D.M.; Latham, M.D.; Rowe, T.C.; Ross, W.E.
    Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line (1989), Biochemistry, 28, 5680-5687.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
4'-(9-acridinylamino)methansulfon-m-anisidide epipodophyllotoxin-resistant line, VpmR-5, is not inhibited Cricetulus griseus
etoposide
-
 Cricetulus griseus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
170000
-
 x * 170000, SDS-PAGE Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ovary cell line wild type and epipodophyllotoxin-resistant line VpmR-5 Cricetulus griseus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Cricetulus griseus

Storage Stability

Storage Stability Organism
-70°C, 10% glycerol, stable for at least 6 months Cricetulus griseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
network of DNA rings + ATP + H2O decatenation Cricetulus griseus monomeric DNA circles + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O catenation Cricetulus griseus catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O relaxation Cricetulus griseus relaxed DNA + ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 170000, SDS-PAGE Cricetulus griseus