Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.2 extracted from

  • Drake, F.H.; Zimmerman, J.P.; McCabe, F.L.; Bartus, H.F.; Per, S.R.; Sullivan, D.M.; Ross, W.E.; Mattern, M.R.; Johnson, R.K.; Crooke, S.T.; Mirabelli, C.K.
    Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells (1987), J. Biol. Chem., 262, 16739-16747.
    View publication on PubMed
Search for more literature for 5.6.2.2

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2 distinct enzyme forms: p170, MW 170000 and p180, MW 180000 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
P-388 cell amsacrine-resistant line and amsacrine sensitive line, 2 distinct enzyme forms: p170 with MW 170000 and p180 with MW 180000 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
network of DNA rings + ATP + H2O decatenation Mus musculus monomeric DNA circles + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O catenation Mus musculus catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O relaxation Mus musculus relaxed DNA + ADP + phosphate
-
 ?