Literature summary for 5.6.1.8 extracted from

Shih, W.M.; Spudich, J.A.
The myosin relay helix to converter interface remains intact throughout the actomyosin ATPase cycle (2001), J. Biol. Chem., 276, 19491-19494.

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Protein Variants

Protein Variants	Comment	Organism
I499C	plus cysteine-light mutations C49S, C312Y, C470I, C599L, C678Y, rescues growth of cells in suspension similarly to wild type, minimal implications on actin binding, ATP-induced actin release, actin-activated ATPase activity	Dictyostelium discoideum
I499C/R738C	plus cysteine-light mutations C49S, C312Y, C470I, C599L, C678Y, rescues growth of cells in suspension similarly to wild type, even after disulfide-induced crosslinking of mutated residues just minimal implications on actin binding, ATP-induced actin release, actin-activated ATPase activity	Dictyostelium discoideum
additional information	enzyme deletion mutant, no growth of cells in suspension	Dictyostelium discoideum
R738C	plus cysteine-light mutations C49S, C312Y, C470I, C599L, C678Y, rescues growth of cells in suspension similarly to wild type, minimal implications on actin binding, ATP-induced actin release, actin-activated ATPase activity	Dictyostelium discoideum

Organism

Organism	UniProt	Comment	Textmining
Dictyostelium discoideum	-	-	-

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Release 2023.1 (January 2023)