Crystallization (Comment) | Organism |
---|---|
mutant enzyme F508del, microbatch method, using 40% (w/v) PEG 400, 100 mM NH4Cl, and 100 mM MES, pH 6.0 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F508del | the in-frame deletion causes cystic fibrosis | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | Homo sapiens | - |
ADP + phosphate + open Cl- channel | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P13569 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography and gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-methyl-dCTP + H2O + closed Cl- channel | - |
Homo sapiens | 5-methyl-dCDP + phosphate + open Cl- channel | - |
? | |
7-methyl-GTP + H2O + closed Cl- channel | - |
Homo sapiens | 7-methyl-GDP + phosphate + open Cl- channel | - |
? | |
ATP + H2O + closed Cl- channel | - |
Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
CTP + H2O + closed Cl- channel | - |
Homo sapiens | CDP + phosphate + open Cl- channel | - |
? | |
dATP + H2O + closed Cl- channel | - |
Homo sapiens | dADP + phosphate + open Cl- channel | - |
? | |
dCTP + H2O + closed Cl- channel | - |
Homo sapiens | dCDP + phosphate + open Cl- channel | - |
? | |
dGTP + H2O + closed Cl- channel | - |
Homo sapiens | dGDP + phosphate + open Cl- channel | - |
? | |
dTTP + H2O + closed Cl- channel | - |
Homo sapiens | dTDP + phosphate + open Cl- channel | - |
? | |
dUTP + H2O + closed Cl- channel | - |
Homo sapiens | dUDP + phosphate + open Cl- channel | - |
? | |
GTP + H2O + closed Cl- channel | - |
Homo sapiens | GDP + phosphate + open Cl- channel | - |
? | |
TTP + H2O + closed Cl- channel | - |
Homo sapiens | TDP + phosphate + open Cl- channel | - |
? | |
UTP + H2O + closed Cl- channel | - |
Homo sapiens | UDP + phosphate + open Cl- channel | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CFTR | - |
Homo sapiens |
cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |