Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-(4-chlorophenylthio)-AMP | the ATPase activity of the enzyme is enhanced in the presence of very low concentrations of 8-(4-chlorophenylthio)-AMP | Homo sapiens | |
additional information | the ATPase activity of the enzyme is enhanced by anion channel inhibitors including glibenclamide, glipizide, and CFTRinh-172 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Chinese hamster ovary and baby hamster kidney cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E1371S | the mutant has no ATPase activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
8-(4-chlorophenylthio)-AMP | the ATPase activity of the enzyme is reduced in the presence of higher concentrations of 8-(4-chlorophenylthio)-AMP | Homo sapiens | |
CFTRinh-172 | i.e., 5-[(4-carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl]4-thiazolidinone | Homo sapiens | |
glibenclamide | - |
Homo sapiens | |
glipizide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | Homo sapiens | - |
ADP + phosphate + open Cl- channel | - |
? | |
ATP + H2O + closed I- channel | Homo sapiens | - |
ADP + phosphate + open I- channel | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation by protein kinase A occurs in the post-hydrolysis transition state of the enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | - |
Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
ATP + H2O + closed I- channel | - |
Homo sapiens | ADP + phosphate + open I- channel | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ABCC7 | - |
Homo sapiens |
CFTR | - |
Homo sapiens |
cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
14 | - |
ATP | partially phosphorylated enzyme, at pH 7.4 and 37°C | Homo sapiens |