Cloned (Comment) | Organism |
---|---|
expression of a construct lacking Cys-residues, in CHO-cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | introduction of cysteine resiudues to a Cys-less mutant and cysteine scanning of TM12 of CFTR using intracellularly applied 2-sulfonatoethyl methanethiosulfonate reagents. Data show high reaction rates of substituted cysteines toward the probes, strong blocker protection of cysteines against reaction, and reaction-induced alterations in channel conductance, supporting the idea that TM12 of CFTR contributes to the lining of the ion permeation pathway | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel | upon channel opening, the wide cytoplasmic vestibule tightens and the pore-lining TM12 rotates along its helical axis | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ABCC7 | - |
Homo sapiens |