Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | lubiprostone and forskolin activate the same pool of apical Cl- channels | Homo sapiens | |
lubiprostone | lubiprostone and forskolin activate the same pool of apical Cl- channels, lubiprostone induces the secretory response in intestinal epithelium involving the enzyme. Lubiprostone enhances intestinal Cl- and fluid secretion via prostanoid receptor signaling, triggering activation of CFTR. The EP4-type prostanoid receptor antagonist L-161982 blocks the lubiprostone response. Lubiprostone enhances Cl- secretion across human large and mall intestinal epithelium through a CFTR-dependent pathway | Homo sapiens | |
lubiprostone | lubiprostone enhances Cl- secretion across mouse ileum through a CFTR-dependent pathway and induces the secretory response in intestinal epithelium involving the enzyme. Lubiprostone enhances intestinal Cl- and fluid secretion via prostanoid receptor signaling, triggering activation of CFTR. The EP4-type prostanoid receptor antagonist L-161982 blocks the lubiprostone response | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bumetanide | blocks CFTR | Homo sapiens | |
CFTRinh172 | blocks CFTR | Homo sapiens | |
additional information | no inhibition of CFTR by CdCl2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | Mus musculus | CFTR is a Cl- channel | ADP + phosphate + open Cl- channel | - |
? | |
ATP + H2O + closed Cl- channel | Homo sapiens | CFTR is a Cl- channel | ADP + phosphate + open Cl- channel | - |
? | |
additional information | Mus musculus | enzyme defects or inhibition lead to cystic fibrosis | ? | - |
? | |
additional information | Homo sapiens | enzyme defects or inhibition lead to cystic fibrosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
wild-type mice, Cftr-null mice, homozygous F508del mice, and Cftr-/- littermates | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ileum | - |
Mus musculus | - |
intestinal epithelium | - |
Mus musculus | - |
intestinal epithelium | - |
Homo sapiens | - |
intestine | - |
Mus musculus | - |
large intestine | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
T-84 cell | derived from a human colon carcinoma | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | CFTR is a Cl- channel | Mus musculus | ADP + phosphate + open Cl- channel | - |
? | |
ATP + H2O + closed Cl- channel | CFTR is a Cl- channel | Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
additional information | enzyme defects or inhibition lead to cystic fibrosis | Mus musculus | ? | - |
? | |
additional information | enzyme defects or inhibition lead to cystic fibrosis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CFTR | - |
Mus musculus |
CFTR | - |
Homo sapiens |
cystic fibrosis transmembrane conductance regulator | - |
Mus musculus |
cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |