Literature summary for 5.6.1.6 extracted from

Fuller, M.D.; Zhang, Z.R.; Cui, G.; McCarty, N.A.
The block of CFTR by scorpion venom is state-dependent (2005), Biophys. J., 89, 3960-3975.

Search for more literature for 5.6.1.6

Application

Application	Comment	Organism
additional information	active scorpion venom of Leirus quinquestriatus hebraeus may be used as a tool to study the conformational changes that occur during CFTR gating	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Xenopus laevis oocytes	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
K1250A	modulation of the on-rate of venom binding for intraburst block	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
adenylyl-imidodiphosphate	modulation of the on-rate of venom binding for intraburst block	Homo sapiens
additional information	diphenylamine-2-carboxylate shows no state-dependence of block	Homo sapiens
vanadate	modulation of the on-rate of venom binding for intraburst block	Homo sapiens
venom	from Leirus quinquestriatus hebraeus, reversly inhibits CFTR, when applied to its cytoplasmic surface, preferentially binds to closed CFTR channels, effectiveness of macroscopic inhibition depends on the level of CFTR channel activity, the venom also binds to CFTR during intraburst closings, efficacy of intraburst inhibition at the single-channel level depends on open probability	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CFTR	-	Homo sapiens
cystic fibrosis transmembrane conductance regulator	-	Homo sapiens

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Release 2023.1 (January 2023)