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Literature summary for 5.6.1.6 extracted from
- Dual effects of ADP and adenylylimidodiphosphate on CFTR channel kinetics show binding to two different nucleotide binding sites (1999), J. Gen. Physiol., 114, 55-70.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Xenopus oocytes | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | the most common mutation in cystic fibrosis, DELTAF508-CFTR, leads to a trafficking-impaired protein that gets degraded in the cell. G551D is a trafficking-competent but misfunctional protein | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenylyliminodiphosphate | - |
Homo sapiens |  |
| ADP | - |
Homo sapiens | |
| ATP-P3-[1-(2-nitrophenyl)ethyl]ester | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | chloride channel | Homo sapiens | ADP + phosphate + open Cl- channel | - |
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