Cloned (Comment) | Organism |
---|---|
6 ATPase subunits of the 26S proteasome cloned | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
700000 | - |
regulatory complex PA700 | Rattus norvegicus |
700000 | - |
regulatory complex PA700 | Saccharomyces cerevisiae |
700000 | - |
regulatory complex PA700 | Thermoplasma sp. |
700000 | - |
proteasome, multicatalytic proteinase complex, central catalytic core | Saccharomyces cerevisiae |
700000 | - |
proteasome, multicatalytic proteinase complex, central catalytic core | Thermoplasma sp. |
2000000 | - |
26S proteasome, ATP-dependent proteolytic complex | Rattus norvegicus |
2000000 | - |
26S proteasome, ATP-dependent proteolytic complex | Thermoplasma sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | Homo sapiens | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Rattus norvegicus | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Saccharomyces cerevisiae | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Thermoplasma sp. | - |
ADP + phosphate + unfolded polypeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
rat | - |
Saccharomyces cerevisiae | - |
- |
- |
Thermoplasma sp. | - |
acidophilum | - |
Purification (Comment) | Organism |
---|---|
26Sproteasome | Thermoplasma sp. |
recombinant rat SuG1, produced in Escherichia coli | Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Homo sapiens | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Rattus norvegicus | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Saccharomyces cerevisiae | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Thermoplasma sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
lung | embryonic lung cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | - |
Homo sapiens | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Rattus norvegicus | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Saccharomyces cerevisiae | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Thermoplasma sp. | ADP + phosphate + unfolded polypeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
26S proteasome | - |
Homo sapiens |
26S proteasome | - |
Rattus norvegicus |
26S proteasome | - |
Saccharomyces cerevisiae |
26S proteasome | - |
Thermoplasma sp. |