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Literature summary for 5.6.1.2 extracted from

  • Ferro, K.L.; Collins, C.A.
    Microtubule-independent phospholipid stimulation of cytoplasmic dynein ATPase activity (1995), J. Biol. Chem., 270, 4492-4496.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine mixture of 0.2 mg/ml phosphatidylserine and phosphatidylcholine leads to an 2.4fold increase in dynein activity Rattus norvegicus
phosphatidylserine mixture of 0.2 mg/ml phosphatidylserine and phosphatidylcholine leads to an 2.4fold increase in dynein activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a dynein associated with a microtubule at position n Rattus norvegicus
-
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.18
-
without activation Rattus norvegicus
0.33
-
in the presence of 0.1 mg/ml phosphatidylserine and phosphatidylcholine, only ATPase activity is activated Rattus norvegicus
0.48
-
in the presence of 0.6 mg/ml microtubules Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a dynein associated with a microtubule at position n
-
Rattus norvegicus ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
?
CTP + H2O + a dynein associated with a microtubule at position n
-
Rattus norvegicus CDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
?
GTP + H2O + a dynein associated with a microtubule at position n
-
Rattus norvegicus GDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
?
TTP + H2O + a dynein associated with a microtubule at position n
-
Rattus norvegicus TDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
?
UTP + H2O + a dynein associated with a microtubule at position n
-
Rattus norvegicus UDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
?