BRENDA - Enzyme Database
show all sequences of 5.4.2.8

Characterization and upregulation of bifunctional phosphoglucomutase/phosphomannomutase enzyme in an exobiopolymer overproducing strain of Acinetobacter haemolyticus

Kaur, T.; Ghosh, M.; Microbiol. Res. 181, 8-14 (2015)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
ADP
50% inhibition at 5 mM
Acinetobacter haemolyticus
ATP
20% inhibition at 5 mM
Acinetobacter haemolyticus
Ca2+
50% inhibition at 5 mM
Acinetobacter haemolyticus
Co2+
78% inhibition at 5 mM
Acinetobacter haemolyticus
D-fructose 6-phosphate
38% inhibition at 5 mM
Acinetobacter haemolyticus
D-Glucose 1,6-bisphosphate
90% inhibition at 5 mM
Acinetobacter haemolyticus
Li+
complete inhibition at 5 mM
Acinetobacter haemolyticus
additional information
not inhibited by Mg2+, D-glucose 6-phosphate, and EDTA
Acinetobacter haemolyticus
Ni2+
96% inhibition at 5 mM
Acinetobacter haemolyticus
UDP-D-glucose
65% inhibition at 5 mM
Acinetobacter haemolyticus
Zn2+
complete inhibition at 5 mM
Acinetobacter haemolyticus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.017
-
alpha-D-mannose 1-phosphate
at pH 7.5 and 35°C
Acinetobacter haemolyticus
0.028
-
alpha-D-glucose 1-phosphate
at pH 7.5 and 35°C
Acinetobacter haemolyticus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Acinetobacter haemolyticus
-
-
-
Purification (Commentary)
Commentary
Organism
ammonium sulfate precipitation, ion exchange column chromatography, and Sephacryl S-100 gel filtration
Acinetobacter haemolyticus
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
45.1
-
cell lysate, at pH 7.5 and 35°C
Acinetobacter haemolyticus
1548
-
after 34.4fold purification, at pH 7.5 and 35°C
Acinetobacter haemolyticus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
alpha-D-glucose 1-phosphate
-
748602
Acinetobacter haemolyticus
D-glucose 6-phosphate
-
-
-
?
alpha-D-mannose 1-phosphate
-
748602
Acinetobacter haemolyticus
D-mannose 6-phosphate
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 50000, SDS-PAGE
Acinetobacter haemolyticus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
-
-
Acinetobacter haemolyticus
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
15
50
about 10% activity at 10°C, about 30% activity at 20°C, about 60% activity at 25°C, about 80% activity at 30°C, 100% activity at 35°C, about 35% activity at 40°C, about 10% activity at 50°C
Acinetobacter haemolyticus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
-
Acinetobacter haemolyticus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
3
9
about 3% activity at pH 3.0-4.0, about 10% activity at pH 5.0, about 80% activity at pH 6.0, 100% activity at pH 7.5, about 30% activity at pH 8.0, about 10% activity at pH 9.0
Acinetobacter haemolyticus
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5
-
at pH 7.5 and 35°C
Acinetobacter haemolyticus
ADP
5
-
at pH 7.5 and 35°C
Acinetobacter haemolyticus
Ca2+
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5
-
at pH 7.5 and 35°C
Acinetobacter haemolyticus
ADP
5
-
at pH 7.5 and 35°C
Acinetobacter haemolyticus
Ca2+
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
ADP
50% inhibition at 5 mM
Acinetobacter haemolyticus
ATP
20% inhibition at 5 mM
Acinetobacter haemolyticus
Ca2+
50% inhibition at 5 mM
Acinetobacter haemolyticus
Co2+
78% inhibition at 5 mM
Acinetobacter haemolyticus
D-fructose 6-phosphate
38% inhibition at 5 mM
Acinetobacter haemolyticus
D-Glucose 1,6-bisphosphate
90% inhibition at 5 mM
Acinetobacter haemolyticus
Li+
complete inhibition at 5 mM
Acinetobacter haemolyticus
additional information
not inhibited by Mg2+, D-glucose 6-phosphate, and EDTA
Acinetobacter haemolyticus
Ni2+
96% inhibition at 5 mM
Acinetobacter haemolyticus
UDP-D-glucose
65% inhibition at 5 mM
Acinetobacter haemolyticus
Zn2+
complete inhibition at 5 mM
Acinetobacter haemolyticus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.017
-
alpha-D-mannose 1-phosphate
at pH 7.5 and 35°C
Acinetobacter haemolyticus
0.028
-
alpha-D-glucose 1-phosphate
at pH 7.5 and 35°C
Acinetobacter haemolyticus
Purification (Commentary) (protein specific)
Commentary
Organism
ammonium sulfate precipitation, ion exchange column chromatography, and Sephacryl S-100 gel filtration
Acinetobacter haemolyticus
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
45.1
-
cell lysate, at pH 7.5 and 35°C
Acinetobacter haemolyticus
1548
-
after 34.4fold purification, at pH 7.5 and 35°C
Acinetobacter haemolyticus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
alpha-D-glucose 1-phosphate
-
748602
Acinetobacter haemolyticus
D-glucose 6-phosphate
-
-
-
?
alpha-D-mannose 1-phosphate
-
748602
Acinetobacter haemolyticus
D-mannose 6-phosphate
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 50000, SDS-PAGE
Acinetobacter haemolyticus
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
-
-
Acinetobacter haemolyticus
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
15
50
about 10% activity at 10°C, about 30% activity at 20°C, about 60% activity at 25°C, about 80% activity at 30°C, 100% activity at 35°C, about 35% activity at 40°C, about 10% activity at 50°C
Acinetobacter haemolyticus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
-
Acinetobacter haemolyticus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
3
9
about 3% activity at pH 3.0-4.0, about 10% activity at pH 5.0, about 80% activity at pH 6.0, 100% activity at pH 7.5, about 30% activity at pH 8.0, about 10% activity at pH 9.0
Acinetobacter haemolyticus
Other publictions for EC 5.4.2.8
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747147
Ji
Structural basis of the molec ...
Homo sapiens
Biochemistry
57
3480-3492
2018
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2
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2
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-
749116
Citro
A mutant of phosphomannomutas ...
Homo sapiens
PLoS ONE
12
e0189629
2017
3
-
1
-
-
-
3
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
5
-
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-
1
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5
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2
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-
5
-
4
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-
2
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-
-
5
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
749264
He
Molecular cloning and functio ...
Dendrobium officinale
Protoplasma
254
1693-1704
2017
-
-
1
-
-
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-
-
1
-
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3
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4
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2
1
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1
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1
-
-
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1
-
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-
-
-
-
-
-
4
-
-
2
1
-
-
-
-
-
-
-
1
1
-
-
1
-
-
749352
Xu
Multiple ligand-bound states ...
Pseudomonas aeruginosa
Sci. Rep.
7
5343
2017
-
-
-
-
1
-
3
-
-
1
-
2
-
1
-
1
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2
1
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1
-
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3
-
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1
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2
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1
-
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-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
748600
Oh
-
Cloning and characterization ...
Vibrio anguillarum, Vibrio anguillarum O1
Microbiol. Biotechnol. Lett.
44
355-362
2016
-
-
1
-
-
-
-
-
-
-
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4
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-
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4
1
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1
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4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
748602
Kaur
Characterization and upregula ...
Acinetobacter haemolyticus
Microbiol. Res.
181
8-14
2015
-
-
-
-
-
-
11
2
-
-
-
-
-
1
-
-
1
-
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-
2
-
2
1
1
1
-
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1
1
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2
-
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-
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-
-
2
11
-
2
-
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-
-
-
-
-
1
-
-
2
-
2
1
1
1
-
-
1
1
-
-
-
-
-
-
-
-
749066
Andreotti
Heterodimerization of two pat ...
Homo sapiens
PLoS ONE
10
e0139882
2015
1
-
1
-
3
-
-
-
-
-
-
-
-
2
-
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1
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2
1
-
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1
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1
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3
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1
-
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2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727988
Lee
Promotion of enzyme flexibilit ...
Pseudomonas aeruginosa
J. Biol. Chem.
289
4674-4682
2014
-
-
1
1
-
-
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-
-
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1
-
1
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1
1
1
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1
1
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1
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1
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1
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1
1
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-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
748183
Andreotti
Conformational response to li ...
Homo sapiens
J. Biol. Chem.
289
34900-34910
2014
2
-
1
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2
-
-
-
-
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3
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1
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2
1
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2
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1
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2
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1
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2
1
-
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-
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-
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-
-
-
-
727228
Huang
Cloning, expression and charac ...
Sphingomonas sanxanigenens, Sphingomonas sanxanigenens NX02
Biotechnol. Lett.
35
1265-1270
2013
-
1
1
-
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1
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4
-
5
-
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1
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4
1
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1
1
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1
1
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1
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4
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1
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4
1
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1
1
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1
1
-
1
1
728329
Bandini
Phosphoglucomutase is absent i ...
Trypanosoma brucei, Trypanosoma brucei 427
Mol. Microbiol.
85
513-534
2012
-
-
1
1
1
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-
1
1
-
-
4
-
4
-
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1
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1
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4
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1
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1
1
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1
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1
1
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1
1
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4
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1
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1
-
-
4
-
1
-
-
-
1
1
-
-
-
3
3
-
1
1
715810
Vega
Expression analysis revealing ...
Homo sapiens
J. Inherit. Metab. Dis.
34
929-939
2011
-
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1
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14
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2
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1
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1
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1
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14
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1
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1
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715973
Chu
DFT investigation on the react ...
Homo sapiens
J. Mol. Model.
17
577-585
2011
-
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1
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1
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1
1
-
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-
701872
Yang
Loss of phosphomannomutase act ...
Streptomyces coelicolor
Appl. Microbiol. Biotechnol.
86
1485-1492
2010
-
-
1
-
-
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1
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1
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4
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1
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1
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1
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1
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1
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1
1
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705202
Yang
-
One-pot enzymatic synthesis of ...
Escherichia coli K-12
J. Mol. Catal. B
62
282-287
2010
-
1
1
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1
-
1
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1
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2
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1
1
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1
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1
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2
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2
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2
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714628
Yu
Molecular analysis of phosphom ...
Aegilops tauschii, Brachypodium distachyon, Hordeum vulgare, Oryza sativa, Triticum aestivum, Triticum turgidum subsp. durum, Triticum urartu
BMC Plant Biol.
10
214
2010
-
-
3
-
-
-
-
3
-
-
-
-
-
18
-
-
3
-
-
-
-
-
13
-
5
3
-
-
-
-
-
-
-
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5
-
-
-
-
-
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3
-
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5
-
-
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-
13
-
6
3
-
-
-
-
-
-
-
-
-
-
-
-
715129
Mitra
A deeply divergent phosphogluc ...
Giardia intestinalis
Glycobiology
20
1233-1240
2010
-
-
1
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
1
-
1
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1
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1
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1
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1
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1
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-
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-
-
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-
-
-
-
693999
Nic Lochlainn
Phosphomannose isomerase and p ...
Streptomyces nodosus
Metab. Eng.
11
40-47
2009
-
1
-
-
1
-
-
-
-
-
-
1
-
3
-
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-
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1
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1
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1
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1
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1
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-
-
-
-
-
-
-
-
694656
Badejo
Increase in ascorbate content ...
Malpighia glabra
Plant Cell Physiol.
50
423-428
2009
1
-
1
-
-
-
-
-
-
-
1
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