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Information on EC 5.4.2.8 - phosphomannomutase
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5.4.2.8 phosphomannomutaseIUBMB Comments
alpha-D-Mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor.
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Word Map
- 5.4.2.8
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carbohydrate-deficient
- transferrin
- gdp-mannose
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multisystemic
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cdg-ia
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team
- mannose-1-phosphate
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pectoralis
- phosphoglucomutase
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doctors
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obstetric
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hypoglycosylation
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nipple
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lipid-linked
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psoas
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premammillary
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strabismus
- paromomycin
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meniscectomy
- medicine
- food industry
- biotechnology
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
pmm, phosphomannomutase, orf17, phosphomannomutase 2, phosphomannomutase2, alpha-d-phosphohexomutase, phosphomannose mutase, alpha-phosphomannomutase1, pmm-1, pmm-2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
EC 2.7.5.7
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formerly
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ORF17
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-
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PGM/PMM
PGM2
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Giardia has two proteins with phosphoglucomutase activity, one of which (PGM2) also has phosphomannomutase activity
phosphoglucomutase/phosphomannomutase
Phosphohexomutase
phosphomannomutase
phosphomannomutase 1
phosphomannomutase/phosphoglucomutase
Phosphomannose mutase
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-
-
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Phosphomutase, mannose
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-
-
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PMM
PMM-A1
PMM-A2
PMM-D1
PMM-D2
PMM/PGM
PMM1
PMM2
PMMH-22
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-
-
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SP-2
SSO0207
PMM
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-
-
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SP-2
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bifunctional enzyme with phosphoglucomutase and phosphomannomutase activities
SP-2
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bifunctional enzyme with phosphoglucomutase and phosphomannomutase activities
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
alpha-D-glucose 1-phosphate = D-glucose 6-phosphate
acid-base catalysis mechanism, key role for conformational change in its multistep reaction, which requires a dramatic 180 degree reorientation of the intermediate within the active site. Modeling shows that increased enzyme flexibility facilitates the reorientation of the reaction intermediate, coupling changes in structural dynamics with the unique catalytic mechanism of this enzyme
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alpha-D-glucose 1-phosphate = D-glucose 6-phosphate
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-
-
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alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
the cosubstrate glucose-1,6-diphosphate is converted to the corresponding sugar monophosphate while the substrate is converted to the sugar biphosphate in each reaction cycle
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alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
the cosubstrate glucose-1,6-diphosphate is converted to the corresponding sugar monophosphate while the substrate is converted to the sugar biphosphate in each reaction cycle
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alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
enzyme is activated by transfer of a phosphate group from mannose-1,6-diphosphate
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alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
group transfer
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intramolecular, phosphate group
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isomerization
isomerization
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-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
alpha-D-mannose 1,6-phosphomutase
alpha-D-Mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor.
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CAS REGISTRY NUMBER
COMMENTARY
59536-73-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-fructose-1-phosphate
D-fructose-6-phosphate
-
no mutase activity
-
-
?
D-glucosamine-1-phosphate
D-glucosamine-6-phosphate
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low enzyme activity
-
-
?
N-acetyl-D-glucosamine-1-phosphate
N-acetyl-D-glucosamine-6-phosphate
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no mutase activity
-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
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-
-
?
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
r
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
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-
-
-
?
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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-
-
?
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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20fold higher activity than with alpha-D-glucose 1-phosphate
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r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
the interconversion occurs via a mannose-1,6-(bis) phosphate intermediate
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-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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-
-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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-
-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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-
-
?
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
PMM/PGM catalyzes the second step in alginate biosynthesis
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r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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second step of the alginate biosynthetic pathway
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r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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20fold higher activity than with alpha-D-glucose 1-phosphate
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r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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preferred substrate
-
-
?
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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preferred substrate
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-
?
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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-
-
?
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
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-
-
?
alpha-D-mannose 1-phosphate
D-mannose 6-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
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-
r
alpha-D-mannose 1-phosphate
D-mannose 6-phosphate
the enzyme also catalyzes the interconversion of alpha-D-glucose 1-phosphate to D-glucose 6-phosphate
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-
?
alpha-D-mannose 1-phosphate
D-mannose 6-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
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r
alpha-D-mannose 1-phosphate
D-mannose 6-phosphate
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-
-
?
alpha-D-mannose 1-phosphate
D-mannose 6-phosphate
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best substrate
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-
?
D-glucose 1-phosphate
D-glucose 6-phosphate
reaction with mannose 1-phosphate is more efficient than with D-glucose-1-phosphate
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?
D-glucose-1-phosphate
D-glucose-6-phosphate
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bifunctional enzyme
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-
?
D-Mannose 1-phosphate
D-Mannose 6-phosphate
reaction with mannose 1-phosphate is more efficient than with D-glucose-1-phosphate
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-
r
D-Mannose 1-phosphate
D-Mannose 6-phosphate
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the cosubstrate glucose-1,6-diphosphate or mannose 1,6-diphosphate is converted to the corresponding sugar monophosphate while the substrate is converted to the sugar biphosphate in each reaction cycle
-
?
D-Mannose 1-phosphate
D-Mannose 6-phosphate
-
the cosubstrate glucose-1,6-diphosphate or mannose 1,6-diphosphate is converted to the corresponding sugar monophosphate while the substrate is converted to the sugar biphosphate in each reaction cycle
-
?
D-Mannose 1-phosphate
D-Mannose 6-phosphate
-
enzyme is activated by transfer of a phosphate group from glucose 1,6-diphosphate or mannose 1,6-diphosphate
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?
D-Mannose 1-phosphate
D-Mannose 6-phosphate
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more slowly in the reverse direction
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?
D-mannose 6-phosphate
alpha-D-mannose 1-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
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-
r
D-mannose 6-phosphate
alpha-D-mannose 1-phosphate
the enzyme also catalyzes the interconversion of alpha-D-glucose 1-phosphate to D-glucose 6-phosphate
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-
?
D-mannose 6-phosphate
D-mannose 1-phosphate
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conversion to mannose 1-phosphate, which is a substrate for the synthesis of GDPmannose. This nucleotide sugar is then used in the synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol anchored proteins
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?
D-mannose 6-phosphate
D-mannose 1-phosphate
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first enzyme of the N-glycosylation pathway
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-
?
D-mannose 6-phosphate
D-mannose 1-phosphate
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the enzyme produces mannose 1-phosphate for the synthesis of mannose-1,6-diphosphate as well as of GDPmannose
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?
D-mannose 6-phosphate
D-mannose 1-phosphate
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the enzyme is required for synthesis of lipopolysaccharide O side chains
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?
D-mannose-1-phosphate
D-mannose-6-phosphate
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bifunctional enzyme
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?
additional information
?
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D-glucose 1,6-bisphosphate and D-mannose 1,6-bisphosphate can be hydrolyzed by isoform PMM1
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?
additional information
?
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D-glucose 1,6-bisphosphate and D-mannose 1,6-bisphosphate can be hydrolyzed by isoform PMM1
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?
additional information
?
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D-glucose 1,6-bisphosphate and D-mannose 1,6-bisphosphate can be hydrolyzed by isoform PMM1
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?
additional information
?
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PMM1 is less specific: it has nearly equal phosphomannomutase and phosphoglucomutase activities as well as a modest glucose-1,6-bisphosphatase activity corresponding to about 3% of its phosphomannomutase activity
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?
additional information
?
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bifunctional enzyme with phosphoglucomutase, EC 5.4.2.2, and phosphomannomutase activities
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?
additional information
?
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bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities, the catalytic efficiency is about 15fold higher for glucose 1-phosphate than for mannose 1-phosphate
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?
additional information
?
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bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities, the catalytic efficiency is about 15fold higher for glucose 1-phosphate than for mannose 1-phosphate
-
-
?
additional information
?
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bifunctional enzyme with phosphoglucomutase and phosphomannomutase, EC 5.4.2.8, activities, the catalytic efficiency is about 15fold higher for glucose 1-phosphate than for mannose 1-phosphate
-
-
?
additional information
?
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the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
-
?
additional information
?
-
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the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
-
?
additional information
?
-
the enzyme exhibits the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-D-glucose 1-phosphate
alpha-D-glucose 6-phosphate
-
-
r
D-mannose 6-phosphate
alpha-D-mannose 1-phosphate
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown
-
-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
-
-
-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
PMM/PGM catalyzes the second step in alginate biosynthesis
-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
-
second step of the alginate biosynthetic pathway
-
r
alpha-D-mannose 1-phosphate
alpha-D-mannose 6-phosphate
-
20fold higher activity than with alpha-D-glucose 1-phosphate
-
r
alpha-D-mannose 1-phosphate