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Literature summary for 4.98.1.1 extracted from
- Expression, purification, and characterization of recombinant mammalian ferrochelatase (1997), Methods Enzymol., 281, 378-387.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Escherichia coli | Homo sapiens |
| overexpression in Escherichia coli | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | - |
Homo sapiens |  |
| Cd2+ | - |
Mus musculus | |
| Hg2+ | - |
Homo sapiens | |
| Hg2+ | - |
Mus musculus | |
| Mn2+ | - |
Homo sapiens | |
| Mn2+ | - |
Mus musculus | |
| N-alkylated porphyrins | - |
Homo sapiens | |
| N-alkylated porphyrins | - |
Mus musculus | |
| Pb2+ | - |
Homo sapiens | |
| Pb2+ | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00819 | - |
protoporphyrin | - |
Homo sapiens | |
| 0.00935 | - |
protoporphyrin | - |
Homo sapiens | |
| 0.0111 | - |
Fe2+ | - |
Mus musculus | |
| 0.0153 | - |
protoporphyrin | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protoporphyrin IX + Fe2+ | Mus musculus | final step of heme biosynthesis | ? | - |
? | |
| protoporphyrin IX + Fe2+ | Homo sapiens | final step of heme biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deuteroporphyrin + Fe2+ | - |
Mus musculus | deuteroheme + 2 H+ | - |
? | |
| deuteroporphyrin + Fe2+ | - |
Homo sapiens | deuteroheme + 2 H+ | - |
? | |
| Fe2+-hematoporphyrin | - |
Mus musculus | ? | - |
? | |
| Fe2+-hematoporphyrin | - |
Homo sapiens | ? | - |
? | |
| mesoporphyrin + Fe2+ | - |
Mus musculus | mesoheme + H+ | - |
? | |
| mesoporphyrin + Fe2+ | - |
Homo sapiens | mesoheme + H+ | - |
? | |
| protoporphyrin + Fe2+ | - |
Mus musculus | protoheme + 2 H+ | - |
? | |
| protoporphyrin + Fe2+ | - |
Homo sapiens | protoheme + 2 H+ | - |
? | |
| protoporphyrin + Zn2+ | - |
Homo sapiens | Zn2+-protoporphyrin + H+ | - |
? | |
| protoporphyrin IX + Fe2+ | final step of heme biosynthesis | Mus musculus | ? | - |
? | |
| protoporphyrin IX + Fe2+ | final step of heme biosynthesis | Homo sapiens | ? | - |
? | |
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