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Literature summary for 4.6.1.19 extracted from

  • Chakrabarti, A.; Ghosh, P.K.; Banerjee, S.; Gaughan, C.; Silverman, R.H.
    RNase L triggers autophagy in response to viral infections (2012), J. Virol., 86, 11311-11321.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
2',5'-Oligoadenylate mediates the enzyme activity, absolutely required for activity Homo sapiens
additional information a dephosphorylated form of 2',5'-oligoadenylate does not activate RNase L Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is active on rRNA, rRNA cleavage products are generated from intact ribosomes in ovarian cancer Hey1b cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEY-1B cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is active on rRNA, rRNA cleavage products are generated from intact ribosomes in ovarian cancer Hey1b cells Homo sapiens ?
-
 ?
additional information the enzyme is active on rRNA Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
RNase L
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction virus-mediated autophagy is deficient in cells lacking RNase L, overview Homo sapiens
physiological function the 2',5'-oligoadenylate/RNase L system is a RNA virus-activated host RNase pathway that disposes of or processes viral and cellular single-stranded RNAs. Activation of RNase L during viral infections induces autophagy, autophagy induction by RNase L modulates viral growth Homo sapiens