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Literature summary for 4.6.1.18 extracted from

  • Debnath, J.; Dasgupta, S.; Pathak, T.
    Comparative inhibitory activity of 3- and 5-functionalized nucleosides on ribonuclease A (2010), Bioorg. Med. Chem., 18, 8257-8263.
    View publication on PubMed
Search for more literature for 4.6.1.18

Inhibitors

Inhibitors Comment Organism Structure
3-amino-N-[2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-succinamic acid
-
 Bos taurus
5'-carboxyadenosine
-
 Bos taurus
5'-carboxythymidine
-
 Bos taurus
additional information inhibitor synthesis, molecular docking to the enzyme, interaction of inhibitors with hydrogen bonding network formation between His12 and His119 of RNase A, overview Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Bos taurus
-
pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-cCMP + H2O
-
 Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
ribonuclease A
-
 Bos taurus
RNase A
-
 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.037
-
 3-amino-N-[2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-succinamic acid pH 7.5, 25°C Bos taurus
0.067
-
 5'-carboxyadenosine pH 7.5, 25°C Bos taurus
0.193
-
 5'-carboxythymidine pH 7.5, 25°C Bos taurus