show all | hide all No of entries

Information on EC 4.6.1.18 - pancreatic ribonuclease

for references in articles please use BRENDA:EC4.6.1.18
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Specifically cleaves at the 3'-side of pyrimidine (uracil or cytosine) phosphate bonds in RNA. The reaction takes place in two steps, with the 2',3'-cyclic phosphodiester intermediates released from the enzyme at the completion of the first step. Hydrolysis of these cyclic compounds occurs at a much slower rate through a reversal of the first step, in which the -OH group of water substitutes for the 2'-OH group of the ribose used in the first step, and does not take place until essentially all the susceptible 3',5'-phosphodiester bonds have been cyclised. The enzyme can act as an endo- or exo ribonuclease.
Specify your search results
Select one or more organisms in this record:
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
an [RNA] containing cytidine
+
=
an [RNA]-3'-cytidine-3'-phosphate
+
a 5'-hydroxy-ribonucleotide-3'-[RNA]
an [RNA] containing uridine
+
=
an [RNA]-3'-uridine-3'-phosphate
+
a 5'-hydroxy-ribonucleotide-3'-[RNA]
Synonyms
alkaline ribonuclease, bovine pancreatic ribonuclease A, bovine seminal RNase, BS-RNase, Ceratitis capitata alkaline ribonuclease, EC 2.7.7.16, EC 3.1.4.22, EC-RNase, Ecp, eosinophil cationic protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]
show the reaction diagram
an [RNA] containing cytidine = an [RNA]-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]
show the reaction diagram
(1a)
-
-
-
an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]
show the reaction diagram
(2)
-
-
-
an [RNA] containing uridine = an [RNA]-3'-uridine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]
show the reaction diagram
(2a)
-
-
-
an [RNA]-3'-cytidine-2',3'-cyclophosphate + H2O = an [RNA]-3'-cytidine-3'-phosphate
show the reaction diagram
(1b)
-
-
-
an [RNA]-3'-uridine-2',3'-cyclophosphate + H2O = an [RNA]-3'-uridine-3'-phosphate
show the reaction diagram
(2b)
-
-
-