Application | Comment | Organism |
---|---|---|
medicine | possible role of glyoxalase I in the chemoresistance displayed by kidney tumor, possible use of glyoxalase I inhibitors as anticancer drugs, increase in glyoxalase I lowers level of the potent apoptosis activator methylglyoxal | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q04760 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
kidney tumor cell | transcription level and glyoxalase I activity are higher in pathological tissues than in normal ones | Homo sapiens | - |
additional information | renal carcinoma cell, clear cell adenocarcinoma, 9fold increase in the transcription levels of glyoxalase I compared with pair-matched noncancerous tissues | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + methylglyoxal | - |
Homo sapiens | S-lactoylglutathione | - |
? | |
glutathione + methylglyoxal | - |
Homo sapiens | S-D-lactoylglutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glyoxalase I | - |
Homo sapiens |