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Literature summary for 4.4.1.5 extracted from
- Comparison of glyoxalase I purified from yeast (Saccharomyces cerevisiae) with the enzyme from mammalian sources (1979), Biochem. J., 183, 23-30.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GSH | non-linear inhibition | Homo sapiens |  |
| GSH | non-linear inhibition | Rattus norvegicus | |
| GSH | non-linear inhibition | Saccharomyces cerevisiae | |
| GSH | non-linear inhibition | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
Phenylglyoxal | - |
Homo sapiens | |
| 0.04 | - |
Phenylglyoxal | - |
Rattus norvegicus | |
| 0.06 | - |
Phenylglyoxal | - |
Rattus norvegicus | |
| 0.1 | - |
Phenylglyoxal | - |
Sus scrofa | |
| 0.13 | - |
methylglyoxal | - |
Homo sapiens | |
| 0.14 | - |
methylglyoxal | - |
Rattus norvegicus | |
| 0.21 | - |
Phenylglyoxal | - |
Saccharomyces cerevisiae | |
| 0.21 | - |
methylglyoxal | - |
Sus scrofa | |
| 0.53 | - |
methylglyoxal | - |
Saccharomyces cerevisiae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
gel filtration | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1130 | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + methylglyoxal | - |
Homo sapiens | S-lactoylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Rattus norvegicus | S-lactoylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Sus scrofa | S-lactoylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Saccharomyces cerevisiae | S-lactoylglutathione | - |
? | |
| glutathione + phenylglyoxal | - |
Homo sapiens | S-mandeloylglutathione | - |
? | |
| glutathione + phenylglyoxal | - |
Rattus norvegicus | S-mandeloylglutathione | - |
? | |
| glutathione + phenylglyoxal | - |
Sus scrofa | S-mandeloylglutathione | - |
? | |
| glutathione + phenylglyoxal | - |
Saccharomyces cerevisiae | S-mandeloylglutathione | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 617 | - |
Phenylglyoxal | - |
Sus scrofa | |
| 983 | - |
methylglyoxal | - |
Sus scrofa | |
| 1070 | - |
Phenylglyoxal | - |
Homo sapiens | |
| 1100 | - |
Phenylglyoxal | - |
Rattus norvegicus | |
| 1130 | - |
methylglyoxal | - |
Homo sapiens | |
| 1180 | - |
methylglyoxal | - |
Rattus norvegicus | |
| 1820 | - |
methylglyoxal | - |
Saccharomyces cerevisiae | |
| 6700 | - |
Phenylglyoxal | - |
Saccharomyces cerevisiae | |
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