Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzimidazole | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Km-values for Gln-containing peptides | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization | ? | - |
? | |
additional information | Carica papaya | N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Carica papaya | - |
- |
- |
Homo sapiens | - |
recombinant | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gln-2-naphthylamide | - |
Carica papaya | pyroglutamyl-2-naphthylamide + NH3 | - |
? | |
Gln1-containing peptide | - |
Homo sapiens | pyroglutamyl peptide | - |
? | |
Glu-2-naphthylamide | - |
Carica papaya | ? | - |
? | |
additional information | N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization | Homo sapiens | ? | - |
? | |
additional information | N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization | Carica papaya | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
cyclization of Glu | Carica papaya |
8 | - |
cyclization of Gln | Carica papaya |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.4 | 7.5 | pH 5.4: about 85% of maximal activity, pH 7.5: about 50% of maximal activity, cyclization of Glu | Carica papaya |
7 | 8 | pH 7.0: about 60% of maximal activity, pH 8.0: optimum, cyclization of Gln | Carica papaya |