Literature summary for 4.3.2.9 extracted from

  • Taniguchi, N.; Meister, A.
    gamma-Glutamyl cyclotransferase from rat kidney. Sulfhydryl groups and isolation of a stable form of the enzyme (1978), J. Biol. Chem., 253, 1799-1806.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxymercuribenzoate 0.5 mM, 43% inhibition of isoenzyme with pI 5.1 Rattus norvegicus
cystamine 10 mM, 57% inhibition of isoenzyme with pI 5.1 Rattus norvegicus
gamma-glutamyl cysteine disulfide 10 mM, 64% inhibition of isoenzyme with pI 5.1 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
amino acid analysis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Holtzman
-
Rattus norvegicus Holtzman
-
Holtzman
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-L-glutamyl-L-amino acid preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids Rattus norvegicus 5-oxoproline + L-amino acid i.e. 2-pyrrolidone-5-carboxylic acid ?
5-L-glutamyl-L-amino acid preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids Rattus norvegicus Holtzman 5-oxoproline + L-amino acid i.e. 2-pyrrolidone-5-carboxylic acid ?
5-L-glutamyl-5-L-glutamyl-L-amino acid
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-amino acid
-
?
5-L-glutamyl-5-L-glutamyl-L-amino acid
-
Rattus norvegicus Holtzman 5-oxoproline + 5-L-glutamyl-L-amino acid
-
?
5-L-glutamyl-5-L-glutamyl-L-alanine
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-alanine
-
?
5-L-glutamyl-5-L-glutamyl-L-alanine
-
Rattus norvegicus Holtzman 5-oxoproline + 5-L-glutamyl-L-alanine
-
?
5-L-glutamyl-5-L-glutamyl-L-glutamine
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-glutamine
-
?
5-L-glutamyl-5-L-glutamyl-L-glutamine
-
Rattus norvegicus Holtzman 5-oxoproline + 5-L-glutamyl-L-glutamine
-
?
5-L-glutamyl-5-L-glutamyl-glycine
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-glycine
-
?
5-L-glutamyl-5-L-glutamyl-glycine
-
Rattus norvegicus Holtzman 5-oxoproline + 5-L-glutamyl-glycine
-
?
5-L-glutamyl-5-L-glutamyl-L-threonine
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-threonine
-
?
5-L-glutamyl-5-L-glutamyl-L-valine
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-valine
-
?
5-L-glutamyl-5-L-glutamyl-L-leucine
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-leucine
-
?
5-L-glutamyl-5-L-glutamyl-L-tyrosine
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-tyrosine
-
?
5-L-glutamyl-5-L-glutamyl-L-glutamate
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-glutamate
-
?
5-L-glutamyl-5-L-glutamyl-L-phenylalanine
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-phenylalanine
-
?
5-L-glutamyl-5-L-glutamyl-L-lysine
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-lysine
-
?
5-L-glutamyl-5-L-glutamyl-L-proline
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-L-proline
-
?
5-L-glutamyl-L-methionine
-
Rattus norvegicus 5-oxoproline + L-methionine
-
?
5-L-glutamyl-L-phenylalanine poor substrate Rattus norvegicus 5-oxoproline + L-phenylalanine
-
?
5-L-glutamyl-L-glutamine best substrate Rattus norvegicus 5-oxoproline + L-glutamine
-
?
5-L-glutamyl-L-alanine
-
Rattus norvegicus 5-L-oxoproline + L-alanine
-
?
5-L-glutamyl-L-alpha-aminobutyrate
-
Rattus norvegicus 5-L-oxoproline + L-alpha-aminobutyrate
-
?
5-L-glutamyl-glycine poor substrate Rattus norvegicus 5-oxoproline + glycine
-
?
5-L-glutamyl-L-glutamate
-
Rattus norvegicus 5-oxoproline + L-glutamate
-
?
5-L-glutamyl-L-aspartate
-
Rattus norvegicus 5-oxoproline + L-aspartate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
two isozymic forms of different pI-values: pI 4.6 and 5.1 Rattus norvegicus
7.5 8
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 9.5 approx. half-maximal activity at pH 6 and 9.5 Rattus norvegicus