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Literature summary for 4.3.1.17 extracted from

  • Kashii, T.; Gomi, T.; Oya, T.; Ishii, Y.; Oda, H.; Maruyama, M.; Kobayashi, M.; Masuda, T.; Yamazaki, M.; Nagata, T.; Tsukada, K.; Nakajima, A.; Tatsu, K.; Mori, H.; Takusagawa, F.; Ogawa, H.; Pitot, H.C.
    Some biochemical and histochemical properties of human liver serine dehydratase (2005), Int. J. Biochem. Cell Biol., 37, 574-589.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
45
-
L-serine pH 8.3, 37°C Rattus norvegicus
50
-
L-serine pH 8.3, 37°C Homo sapiens
57
-
L-threonine pH 8.3, 37°C Rattus norvegicus
57
-
L-threonine pH 8.3, 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
2 * 33000, SDS-PAGE, 2 * 34702, calculated Homo sapiens
34702
-
2 * 33000, SDS-PAGE, 2 * 34702, calculated Homo sapiens
60000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P20132
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein expressed in Escherichia coli Rattus norvegicus
recombinant protein expressed in Escherichia coli Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver confined to periportal region Rattus norvegicus
-
liver predominantly localized in perivenous region Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
96
-
substrate L-threonine, pH 8.3, 37°C Homo sapiens
116
-
substrate L-threonine, pH 8.3, 37°C Rattus norvegicus
137
-
substrate L-serine, pH 8.3, 37°C Homo sapiens
200
-
substrate L-serine, pH 8.3, 37°C Rattus norvegicus

Storage Stability

Storage Stability Organism
-80°C, stable for more than 2 weeks Homo sapiens
0°C, stable for at least 2 weeks Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
Rattus norvegicus pyruvate + NH3
-
?
L-serine
-
Homo sapiens pyruvate + NH3
-
?
L-threonine
-
Rattus norvegicus 2-oxobutyrate + NH3
-
?
L-threonine
-
Homo sapiens 2-oxobutyrate + NH3
-
?

Subunits

Subunits Comment Organism
dimer 2 * 33000, SDS-PAGE, 2 * 34702, calculated Homo sapiens