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Information on EC - L-serine ammonia-lyase

for references in articles please use BRENDA:EC4.3.1.17
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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
       L-serine ammonia-lyase
IUBMB Comments
Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead . The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC, L-serine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond. The latter reaction, which can occur spontaneously, is also be catalysed by EC, 2-iminobutanoate/2-iminopropanoate deaminase. This reaction is also carried out by EC, threonine ammonia-lyase, from a number of sources.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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serine dehydratase, l-serine dehydratase, l-threonine deaminase, l-threonine dehydratase, l-serine deaminase, serine deaminase, serdh, lplsd, l-sd2, msmeg_3532, more
2-aminoprop-2-enoate = 2-iminopropanoate
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(1b), spontaneous
2-iminopropanoate + H2O = pyruvate + NH3
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(1c), spontaneous
L-serine = 2-aminoprop-2-enoate + H2O
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L-serine = pyruvate + NH3
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