Literature summary for 4.2.3.82 extracted from

Scalcinati, G.; Knuf, C.; Partow, S.; Chen, Y.; Maury, J.; Schalk, M.; Daviet, L.; Nielsen, J.; Siewers, V.
Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene alpha-santalene in a fed-batch mode (2012), Metab. Eng., 14, 91-103.

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Application

Application	Comment	Organism
synthesis	construction of a Saccharomyces cerevisiae strain capable of producing high levels of alpha-santalene through a rationally designed metabolic engineering approach.Optimal sesquiterpene production is obtained by modulating the expression of one of the keymetabolic steps of the mevalonate pathway, squalene synthase Erg9. Further optimization yields a final titer of 92 mg/l of alpha-santalene	Clausena lansium

Organism

Organism	UniProt	Comment	Textmining
Clausena lansium	E5LLI1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 (2E,6E)-farnesyl diphosphate	-	Clausena lansium	(+)-alpha-santalene + trans-alpha-bergamotene + 2 diphosphate	amounts of the sesquiterpenes alpha-santalene and trans-alpha-bergamotene produced are,respectively,1.45 and0.177 mg/l	?

Synonyms

Synonyms	Comment	Organism
Tps2-1	-	Clausena lansium

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Release 2023.1 (January 2023)