BRENDA - Enzyme Database
show all sequences of 4.2.3.82

Sandalwood fragrance biosynthesis involves sesquiterpene synthases of both the terpene synthase (TPS)-a and TPS-b subfamilies, including santalene synthases

Jones, C.G.; Moniodis, J.; Zulak, K.G.; Scaffidi, A.; Plummer, J.A.; Ghisalberti, E.L.; Barbour, E.L.; Bohlmann, J.; J. Biol. Chem. 286, 17445-17454 (2011)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expression in Escherichia coli; heterologous expression of a His6-tagged protein in Escherichia coli
Santalum album
expression in Escherichia coli; heterologous expression of a His6-tagged protein in Escherichia coli
Santalum austrocaledonicum
expression in Escherichia coli; heterologous expression of a His6-tagged protein in Escherichia coli
Santalum spicatum
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0014
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum album
0.0014
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum austrocaledonicum
0.0014
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum spicatum
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum album
Mg2+
required; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum austrocaledonicum
Mg2+
required; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum spicatum
Mn2+
when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum album
Mn2+
incubation in presence of Mn2+ yields mainly alpha-exo-bergamotene; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum austrocaledonicum
Mn2+
incubation in presence of Mn2+ yields mainly exo-alpha-bergamotene; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum spicatum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
65163
-
x * 65163, calculated from sequence
Santalum album
65268
-
x * 65268, calculated from sequence
Santalum austrocaledonicum
65407
-
x * 65407, calculated from sequence
Santalum spicatum
66000
-
-
Santalum album
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
(2E,6E)-farnesyl diphosphate
Santalum album
-
(+)-alpha-santalene + diphosphate
-
-
?
(2E,6E)-farnesyl diphosphate
Santalum austrocaledonicum
-
(+)-alpha-santalene + diphosphate
-
-
?
(2E,6E)-farnesyl diphosphate
Santalum spicatum
-
(+)-alpha-santalene + diphosphate
-
-
?
(2E,6E)-farnesyl diphosphate
Santalum austrocaledonicum
-
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene
-
?
(2E,6E)-farnesyl diphosphate
Santalum spicatum
-
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene
-
?
(2E,6E)-farnesyl diphosphate
Santalum album
-
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene
-
?
additional information
Santalum album
Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (E,E)-FPP resembles the authentic essential oil of Santalum album more closely than that of the (Z,Z)-FPP incubations
?
-
-
-
additional information
Santalum austrocaledonicum
Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
?
-
-
-
additional information
Santalum spicatum
Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
?
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Santalum album
E3W202
-
-
Santalum austrocaledonicum
E3W203
-
-
Santalum spicatum
E3W204
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
xylem
-
Santalum album
-
xylem
-
Santalum austrocaledonicum
-
xylem
-
Santalum spicatum
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
(2E,6E)-farnesyl diphosphate
-
715604
Santalum album
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum austrocaledonicum
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum spicatum
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
715604
Santalum album
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
715604
Santalum austrocaledonicum
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
715604
Santalum spicatum
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
when incubated in the presence of 10 mM Mg2+ the enzyme converts (2Z,6Z)-farnesyl diphosphate into alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene and beta-santalene
715604
Santalum album
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum austrocaledonicum
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum spicatum
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum album
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene
-
-
?
additional information
Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (E,E)-FPP resembles the authentic essential oil of Santalum album more closely than that of the (Z,Z)-FPP incubations
715604
Santalum album
?
-
-
-
-
additional information
Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
715604
Santalum austrocaledonicum
?
-
-
-
-
additional information
Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
715604
Santalum spicatum
?
-
-
-
-
additional information
Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
715604
Santalum album
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 65163, calculated from sequence; x * 66000, SDS-PAGE of recombinant His-tagged protein
Santalum album
?
x * 65268, calculated from sequence
Santalum austrocaledonicum
?
x * 65407, calculated from sequence
Santalum spicatum
Synonyms
Synonyms
Commentary
Organism
SaSSy
-
Santalum album
SspiSy
-
Santalum spicatum
SSy
-
Santalum album
SSy
-
Santalum austrocaledonicum
SSy
-
Santalum spicatum
SuSSy
-
Santalum austrocaledonicum
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Santalum album
25
-
assay at
Santalum austrocaledonicum
25
-
assay at
Santalum spicatum
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.34
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum album
0.91
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum austrocaledonicum
2.6
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum spicatum
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Santalum album
7.4
-
assay at
Santalum austrocaledonicum
7.4
-
assay at
Santalum spicatum
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli; heterologous expression of a His6-tagged protein in Escherichia coli
Santalum album
expression in Escherichia coli; heterologous expression of a His6-tagged protein in Escherichia coli
Santalum austrocaledonicum
expression in Escherichia coli; heterologous expression of a His6-tagged protein in Escherichia coli
Santalum spicatum
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0014
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum album
0.0014
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum austrocaledonicum
0.0014
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum spicatum
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum album
Mg2+
required; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum austrocaledonicum
Mg2+
required; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum spicatum
Mn2+
when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum album
Mn2+
incubation in presence of Mn2+ yields mainly alpha-exo-bergamotene; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum austrocaledonicum
Mn2+
incubation in presence of Mn2+ yields mainly exo-alpha-bergamotene; when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
Santalum spicatum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
65163
-
x * 65163, calculated from sequence
Santalum album
65268
-
x * 65268, calculated from sequence
Santalum austrocaledonicum
65407
-
x * 65407, calculated from sequence
Santalum spicatum
66000
-
-
Santalum album
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
(2E,6E)-farnesyl diphosphate
Santalum album
-
(+)-alpha-santalene + diphosphate
-
-
?
(2E,6E)-farnesyl diphosphate
Santalum austrocaledonicum
-
(+)-alpha-santalene + diphosphate
-
-
?
(2E,6E)-farnesyl diphosphate
Santalum spicatum
-
(+)-alpha-santalene + diphosphate
-
-
?
(2E,6E)-farnesyl diphosphate
Santalum austrocaledonicum
-
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene
-
?
(2E,6E)-farnesyl diphosphate
Santalum spicatum
-
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene
-
?
(2E,6E)-farnesyl diphosphate
Santalum album
-
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene
-
?
additional information
Santalum album
Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (E,E)-FPP resembles the authentic essential oil of Santalum album more closely than that of the (Z,Z)-FPP incubations
?
-
-
-
additional information
Santalum austrocaledonicum
Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
?
-
-
-
additional information
Santalum spicatum
Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
xylem
-
Santalum album
-
xylem
-
Santalum austrocaledonicum
-
xylem
-
Santalum spicatum
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
(2E,6E)-farnesyl diphosphate
-
715604
Santalum album
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum austrocaledonicum
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum spicatum
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
715604
Santalum album
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
715604
Santalum austrocaledonicum
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene
715604
Santalum spicatum
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
when incubated in the presence of 10 mM Mg2+ the enzyme converts (2Z,6Z)-farnesyl diphosphate into alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene and beta-santalene
715604
Santalum album
(+)-alpha-santalene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum austrocaledonicum
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum spicatum
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene
-
-
?
(2E,6E)-farnesyl diphosphate
-
715604
Santalum album
alpha-santalene + diphosphate
products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene
-
-
?
additional information
Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (E,E)-FPP resembles the authentic essential oil of Santalum album more closely than that of the (Z,Z)-FPP incubations
715604
Santalum album
?
-
-
-
-
additional information
Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
715604
Santalum austrocaledonicum
?
-
-
-
-
additional information
Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
715604
Santalum spicatum
?
-
-
-
-
additional information
Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene
715604
Santalum album
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 65163, calculated from sequence; x * 66000, SDS-PAGE of recombinant His-tagged protein
Santalum album
?
x * 65268, calculated from sequence
Santalum austrocaledonicum
?
x * 65407, calculated from sequence
Santalum spicatum
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Santalum album
25
-
assay at
Santalum austrocaledonicum
25
-
assay at
Santalum spicatum
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.34
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum album
0.91
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum austrocaledonicum
2.6
-
(2E,6E)-farnesyl diphosphate
30°C, pH 8.0; pH 7.4, 25°C
Santalum spicatum
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Santalum album
7.4
-
assay at
Santalum austrocaledonicum
7.4
-
assay at
Santalum spicatum
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
242.9
-
(2E,6E)-farnesyl diphosphate
pH 7.4, 25°C
Santalum album
650
-
(2E,6E)-farnesyl diphosphate
pH 7.4, 25°C
Santalum austrocaledonicum
1857
-
(2E,6E)-farnesyl diphosphate
pH 7.4, 25°C
Santalum spicatum
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
242.9
-
(2E,6E)-farnesyl diphosphate
pH 7.4, 25°C
Santalum album
650
-
(2E,6E)-farnesyl diphosphate
pH 7.4, 25°C
Santalum austrocaledonicum
1857
-
(2E,6E)-farnesyl diphosphate
pH 7.4, 25°C
Santalum spicatum
Other publictions for EC 4.2.3.82
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746736
Hua
Characterization of santalene ...
Clausena lansium, Santalum album, Santalum spicatum
Anal. Biochem.
547
26-36
2018
-
-
3
-
-
-
-
6
-
3
-
6
-
5
-
-
3
-
-
1
2
-
9
1
6
3
-
-
3
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
6
-
3
-
6
-
-
-
3
-
1
2
-
9
1
3
-
-
3
3
-
-
-
-
2
2
-
3
3
729798
Rani
Molecular regulation of santal ...
Santalum album
Gene
527
642-648
2013
-
-
1
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
730317
Scalcinati
Dynamic control of gene expres ...
Clausena lansium
Metab. Eng.
14
91-103
2012
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
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1
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
715604
Jones
Sandalwood fragrance biosynthe ...
Santalum album, Santalum austrocaledonicum, Santalum spicatum
J. Biol. Chem.
286
17445-17454
2011
-
-
3
-
-
-
-
3
-
6
4
9
-
3
-
-
-
-
-
3
-
-
14
3
6
3
-
-
3
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
3
-
6
4
9
-
-
-
-
-
3
-
-
14
3
3
-
-
3
3
-
-
-
-
-
-
-
3
3