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Literature summary for 4.2.2.1 extracted from

  • Li, S.; Jedrzejas, M.J.
    Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase (2001), J. Biol. Chem., 276, 41407-41416.
    View publication on PubMed
Search for more literature for 4.2.2.1

Crystallization (Commentary)

Crystallization (Comment) Organism
purified free enzyme and enzyme-product complex, X-ray diffraction structure determination and analysis at 2.1-2.2 A resolution Streptococcus agalactiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus agalactiae enzyme is a virulence factor that helps the pathogen to brake through the biophysical barrier of the host tissues ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus agalactiae Q53591 gene hylB3502, strain 3502
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation probably by autolytic cleavage Streptococcus agalactiae

Reaction

Reaction Comment Organism Reaction ID
[hyaluronate]n = (4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1 + 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + hyaluronate substrate binding, structure and mechanims, and reaction mechanism, catalytic residues are His479, Tyr488, and Asn429, modeling of binding of a tetrasaccharide in the active site cleft Streptococcus agalactiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chondroitin sulfate degrades progressively unsulfated and 6-sulfated regions from the reducing end Streptococcus agalactiae ?
-
 ?
hyaluronan progressive degradation from the reducing end Streptococcus agalactiae 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
 ?
additional information enzyme is a virulence factor that helps the pathogen to brake through the biophysical barrier of the host tissues Streptococcus agalactiae ?
-
 ?

Subunits

Subunits Comment Organism
? 3 different form of 118, 111, and 92 kDa, the 118 kDa form is inactive Streptococcus agalactiae

Synonyms

Synonyms Comment Organism
SagHL
-
 Streptococcus agalactiae