show all | hide all No of entries

Information on EC 4.2.2.1 - hyaluronate lyase

for references in articles please use BRENDA:EC4.2.2.1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.2 Acting on polysaccharides
                4.2.2.1 hyaluronate lyase
IUBMB Comments
The enzyme catalyses the degradation of hyaluronan by a beta-elimination reaction. Also acts on chondroitin. The product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
mucinase, hylp2, hyaluronan lyase, bacterial hyaluronidase, hyaluronidase sd, spnhl, ha lyase, hylb4755, spnhyal, acidic hyase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
show the reaction diagram
PATHWAY SOURCE
PATHWAYS