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Literature summary for 4.2.1.9 extracted from

  • Babu, B.N.; Brown, O.R.
    Quantitative effects of redox-cycling chemicals on the oxidant-sensitive enzyme dihydroxy-acid dehydratase (1995), Microbios, 82, 157-170.
    View publication on PubMed
Search for more literature for 4.2.1.9

Application

Application Comment Organism
analysis the enzyme is used to quantify and investigate the biological oxidant stress activity of various redox-cycling chemicals. High sensitivity to inactivation by oxidants makes the enzyme useful for identification of compounds which increase oxyradical flux in the cell and for probing their mechanism of action Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
3-(5-nitrofuran-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
-
 Escherichia coli
benzoquinone
-
 Escherichia coli
duroquinone
-
 Escherichia coli
hydralazine
-
 Escherichia coli
juglone
-
 Escherichia coli
Nitrofurantoin
-
 Escherichia coli
paraquat
-
 Escherichia coli
Plumbagin
-
 Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Iron contains a catalytically active [4Fe-4S] cluster Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 K-12
-
Escherichia coli
-
 CGSC strain 5073
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-dihydroxy-3-methylbutanoate
-
 Escherichia coli 2-oxoisovalerate + H2O
-
 ?
2,3-dihydroxy-3-methylpentanoate
-
 Escherichia coli 3-methyl-2-oxopentanoate + H2O
-
 ?