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Literature summary for 4.2.1.9 extracted from

  • Armstrong, F.B.; Muller, U.S.; Reary, J.B.; Whitehouse, D.; Crout, D.H.G.
    Stereoselectivity and stereospecificity of the alpha,beta-dihydroxyacid dehydratase from Salmonella typhimurium (1977), Biochim. Biophys. Acta, 498, 282-293.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
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Reaction

Reaction Comment Organism Reaction ID
2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O stereochemistry, elimination and protonation steps are stereospecific, enol-keto conversion takes place with proton addition at C-3 to the same face of the enol as that of the departing hydroxy-group Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-dihydroxy-3-methylbutanoate no activity with 2S-2,3-dihydroxy-3-methylbutanoate Salmonella enterica subsp. enterica serovar Typhimurium 2-oxoisovalerate + H2O
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2,3-dihydroxy-3-methylbutanoate 2R-2,3-dihydroxy-3-methylbutanoate Salmonella enterica subsp. enterica serovar Typhimurium 2-oxoisovalerate + H2O
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2,3-dihydroxy-3-methylpentanoate 2R,3R-dihydroxy-3-methylpentanoate, 2R,3S-dihydroxy-3-methylpentanoate, no activity with isomers with 2S configuration Salmonella enterica subsp. enterica serovar Typhimurium 3-methyl-2-oxopentanoate + H2O
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