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Literature summary for 4.2.1.1 extracted from

  • Akdemir, A.; Vullo, D.; De Luca, V.; Scozzafava, A.; Carginale, V.; Rossi, M.; Supuran, C.T.; Capasso, C.
    The extremo-alpha-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines (2013), Bioorg. Med. Chem. Lett., 23, 1087-1090.
    View publication on PubMed
Search for more literature for 4.2.1.1

Activating Compound

Activating Compound Comment Organism Structure
2-pyridylmethylamine moderate activator Sulfurihydrogenibium azorense
D-His moderate activator Sulfurihydrogenibium azorense
D-Phe high activator Sulfurihydrogenibium azorense
D-Trp high activator Sulfurihydrogenibium azorense
dopamine high activator Sulfurihydrogenibium azorense
L-adrenaline moderate activator Sulfurihydrogenibium azorense
L-Dopa high activator Sulfurihydrogenibium azorense
L-His moderate activator Sulfurihydrogenibium azorense
L-Phe moderate activator Sulfurihydrogenibium azorense
L-Trp high activator Sulfurihydrogenibium azorense
L-Tyr moderate activator Sulfurihydrogenibium azorense
serotonin high activator Sulfurihydrogenibium azorense

Organism

Organism UniProt Comment Textmining
Sulfurihydrogenibium azorense
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Sulfurihydrogenibium azorense H2CO3
-
 ?

Synonyms

Synonyms Comment Organism
alpha-carbonic anhydrase
-
 Sulfurihydrogenibium azorense
SazCA
-
 Sulfurihydrogenibium azorense

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Sulfurihydrogenibium azorense

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4400000
-
 CO2 pH 7.5, 25°C, without activator Sulfurihydrogenibium azorense
15000000
-
 CO2 pH 7.5, 25°C, 10 microM L-Phe Sulfurihydrogenibium azorense
33000000
-
 CO2 pH 7.5, 25°C, 10 microM D-Phe Sulfurihydrogenibium azorense

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Sulfurihydrogenibium azorense