Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-phenylacetamido)-3-bromobenzenesulfonamide | - |
Homo sapiens | |
4-(2-phenylacetamido)-3-chlorobenzenesulfonamide | - |
Homo sapiens | |
4-(2-phenylacetamido)-3-fluorobenzenesulfonamide | - |
Homo sapiens | |
4-(2-phenylacetamido)benzenesulfonamide | - |
Homo sapiens | |
4-(2-phenylacetamidoethyl)benzenesulfonamide | - |
Homo sapiens | |
4-(2-phenylacetamidomethyl)benzenesulfonamide | - |
Homo sapiens | |
4-(2-pyridin-2-ylacetamido)benzenesulfonamide | - |
Homo sapiens | |
4-(2-pyridin-4-ylacetamido)benzenesulfonamide | - |
Homo sapiens | |
4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide | - |
Homo sapiens | |
4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide | - |
Homo sapiens | |
4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide | - |
Homo sapiens | |
4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide | - |
Homo sapiens | |
4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide | - |
Homo sapiens | |
4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide | - |
Homo sapiens | |
4-[2-(2-thienyl)acetamido]benzenesulfonamide | - |
Homo sapiens | |
5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
acetazolamide | - |
Homo sapiens | |
topiramate | - |
Homo sapiens | |
zonisamide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoforms CA I and CA II | Homo sapiens | 5829 | - |
mitochondrion | isoforms CA VA and CA VB | Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | Homo sapiens | - |
H2CO3 | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P35218 | - |
- |
Homo sapiens | Q9Y2D0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
r |
Synonyms | Comment | Organism |
---|---|---|
CA I | isoform | Homo sapiens |
CA II | isoform | Homo sapiens |
CA VA | isoform | Homo sapiens |
CA VB | isoform | Homo sapiens |
carbonic anhydrase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0054 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | acetazolamide | |
0.0059 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-bromobenzenesulfonamide | |
0.0061 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide | |
0.0067 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)benzenesulfonamide | |
0.0068 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-2-ylacetamido)benzenesulfonamide | |
0.0068 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-2-ylacetamido)benzenesulfonamide | |
0.0069 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide | |
0.007 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]benzenesulfonamide | |
0.0071 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-bromobenzenesulfonamide | |
0.0072 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]benzenesulfonamide | |
0.0072 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide | |
0.0073 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-4-ylacetamido)benzenesulfonamide | |
0.0074 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide | |
0.0075 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide | |
0.0076 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide | |
0.0076 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide | |
0.0077 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide | |
0.0079 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide | |
0.0079 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)benzenesulfonamide | |
0.008 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide | |
0.0081 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamidoethyl)benzenesulfonamide | |
0.0081 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-fluorobenzenesulfonamide | |
0.0081 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-chlorobenzenesulfonamide | |
0.0082 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-chlorobenzenesulfonamide | |
0.0082 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamidoethyl)benzenesulfonamide | |
0.0083 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-fluorobenzenesulfonamide | |
0.0083 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamidomethyl)benzenesulfonamide | |
0.0084 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide | |
0.0086 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide | |
0.0087 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide | |
0.009 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-4-ylacetamido)benzenesulfonamide | |
0.0091 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide | |
0.0093 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide | |
0.01 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | topiramate | |
0.0102 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide | |
0.012 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | acetazolamide | |
0.02 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | zonisamide | |
0.03 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | topiramate | |
0.035 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | zonisamide | |
0.05 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]benzenesulfonamide | |
0.05 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide | |
0.051 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide | |
0.051 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide | |
0.052 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide | |
0.052 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide | |
0.053 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide | |
0.054 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamidomethyl)benzenesulfonamide | |
0.056 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | zonisamide | |
0.058 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-chlorobenzenesulfonamide | |
0.06 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide | |
0.06 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamidoethyl)benzenesulfonamide | |
0.061 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]benzenesulfonamide | |
0.061 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-chlorobenzenesulfonamide | |
0.061 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-fluorobenzenesulfonamide | |
0.063 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide | |
0.063 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | acetazolamide | |
0.063 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | topiramate | |
0.067 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-fluorobenzenesulfonamide | |
0.067 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamidoethyl)benzenesulfonamide | |
0.068 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide | |
0.069 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-2-ylacetamido)benzenesulfonamide | |
0.071 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-4-ylacetamido)benzenesulfonamide | |
0.072 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide | |
0.073 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide | |
0.074 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-4-ylacetamido)benzenesulfonamide | |
0.075 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamidomethyl)benzenesulfonamide | |
0.075 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-2-ylacetamido)benzenesulfonamide | |
0.077 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide | |
0.084 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide | |
0.086 | - |
carbonic anhydrase VA, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamidomethyl)benzenesulfonamide | |
0.097 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide | |
0.107 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)benzenesulfonamide | |
0.108 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)benzenesulfonamide | |
0.161 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide | |
0.25 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | acetazolamide | |
0.25 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | topiramate | |
0.263 | - |
carbonic anhydrase I, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-bromobenzenesulfonamide | |
0.39 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide | |
0.395 | - |
carbonic anhydrase II, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | 4-(2-phenylacetamido)-3-bromobenzenesulfonamide | |
6.033 | - |
carbonic anhydrase VB, in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C | Homo sapiens | zonisamide |