Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6-4) photoproduct (in DNA) | Xenopus laevis | - |
2 pyrimidine residues (in DNA) | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | Q9I910 | - |
- |
Source Tissue | Comment | Organism | Textmining |
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Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6-4) photoproduct (in DNA) | - |
Xenopus laevis | 2 pyrimidine residues (in DNA) | - |
? | |
additional information | polarizable molecular dynamics simulations and constrained density functional theory calculations reveal the energetics of charge migration along the tryptophan tetrad. Migration toward the fourth tryptophan is thermodynamically favorable. Electron transfer mechanisms occur either through an incoherent hopping mechanism or through a multiple sites tunneling process. The Jortner-Bixon formulation of electron transfer (ET) theory is employed to characterize the hopping mechanism, interplay between electron transfer and relaxation of protein and solvent, overview. Electron transfer in (6-4) photolyase proceeds out of equilibrium. Multiple site tunneling is modeled with the recently proposed flickering resonance mechanism | Xenopus laevis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
(6-4) photolyase | - |
Xenopus laevis |
animal (6-4) photolyase | - |
Xenopus laevis |
Xl64phr | - |
Xenopus laevis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | flavoprotein | Xenopus laevis |
General Information | Comment | Organism |
---|---|---|
evolution | cryptochromes and photolyases are flavoproteins that undergo cascades of electron/hole transfers after excitation of the flavin cofactor. Animal (6-4) photolyases, as well as animal cryptochromes, feature a chain of four tryptophan residues, while other members of the family contain merely a tryptophan triad | Xenopus laevis |
additional information | in Xenopus laevis (6-4) photolyase, the fourth residue of a chain of four tryptophan residues is effectively involved in photoreduction | Xenopus laevis |