BRENDA - Enzyme Database
show all sequences of 4.1.3.1

Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2-hydroxybenzanilides, their thioxo analogues and benzoxazoles

Kozic, J.; Novotna, E.; Volkova, M.; Stolarikova, J.; Trejtnar, F.; Wsol, V.; Vinsova, J.; Eur. J. Med. Chem. 56, 108-119 (2012)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium avium
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium avium
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium kansasii
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium avium
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium avium
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium kansasii
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium avium
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium avium
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
additional information
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium avium
additional information
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium kansasii
additional information
design, synthesis, inhibitory potencies against the enzyme, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium avium
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium avium
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium avium
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium avium
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
isocitrate
Mycobacterium avium
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium tuberculosis
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium kansasii
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium kansasii My 235/80
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium avium My 330/88
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium kansasii 6509/96
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium tuberculosis My 331/88
-
succinate + glyoxylate
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Mycobacterium avium
-
-
-
Mycobacterium avium My 330/88
-
-
-
Mycobacterium kansasii
-
-
-
Mycobacterium kansasii 6509/96
-
-
-
Mycobacterium kansasii My 235/80
-
-
-
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis My 331/88
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
isocitrate
-
727419
Mycobacterium avium
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium tuberculosis
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium kansasii
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium kansasii My 235/80
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium avium My 330/88
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium kansasii 6509/96
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium tuberculosis My 331/88
succinate + glyoxylate
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
ICL
-
Mycobacterium avium
ICL
-
Mycobacterium kansasii
ICL
-
Mycobacterium tuberculosis
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Mycobacterium avium
37
-
assay at
Mycobacterium kansasii
37
-
assay at
Mycobacterium tuberculosis
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Mycobacterium avium
7
-
assay at
Mycobacterium kansasii
7
-
assay at
Mycobacterium tuberculosis
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00298
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
0.00314
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
0.00316
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00369
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
0.00372
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00388
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
0.0039
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
0.00409
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
0.00445
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00491
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
0.00511
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00563
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
0.00574
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
0.00586
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
0.00653
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
0.00734
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
0.0076
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
0.00798
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
0.00849
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.0086
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00874
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
0.01152
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
0.01543
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
0.02537
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
0.04662
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
0.0513
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
0.08702
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00298
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
0.00314
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
0.00316
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00369
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
0.00372
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00388
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
0.0039
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
0.00409
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
0.00445
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00491
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
0.00511
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00563
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
0.00574
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
0.00586
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
0.00653
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
0.00734
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
0.0076
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
0.00798
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
0.00849
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.0086
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
0.00874
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
0.01152
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
0.01543
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
0.02537
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
0.04662
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
0.0513
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
0.08702
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium avium
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium avium
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium kansasii
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium avium
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium avium
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium kansasii
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium avium
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium avium
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
additional information
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium avium
additional information
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium kansasii
additional information
design, synthesis, inhibitory potencies against the enzyme, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium avium
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium avium
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium avium
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium avium
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
isocitrate
Mycobacterium avium
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium tuberculosis
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium kansasii
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium kansasii My 235/80
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium avium My 330/88
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium kansasii 6509/96
-
succinate + glyoxylate
-
-
?
isocitrate
Mycobacterium tuberculosis My 331/88
-
succinate + glyoxylate
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
isocitrate
-
727419
Mycobacterium avium
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium tuberculosis
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium kansasii
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium kansasii My 235/80
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium avium My 330/88
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium kansasii 6509/96
succinate + glyoxylate
-
-
-
?
isocitrate
-
727419
Mycobacterium tuberculosis My 331/88
succinate + glyoxylate
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Mycobacterium avium
37
-
assay at
Mycobacterium kansasii
37
-
assay at
Mycobacterium tuberculosis
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Mycobacterium avium
7
-
assay at
Mycobacterium kansasii
7
-
assay at
Mycobacterium tuberculosis
Other publictions for EC 4.1.3.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)