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(1R,2R,6E)-8-(2,5-dihydroxyphenyl)-2-hydroxy-6-methyl-1-[[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl]oct-6-en-1-yl hydrogen sulfate
-
-
(1S,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylic acid
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(2-bromo-4,5-dihydroxybenzyl)(2,3-dibromo-4,5-dihydroxybenzyl) ether
-
-
(2-bromo-4,5-dihydroxyphenyl)(3,4-dihydroxyphenyl) ether
-
-
(2E,6E)-9-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2,6-dimethylnona-2,6-dienal
-
-
(2E,7E)-10-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-3,7-dimethyl-2-(2-methylprop-1-en-1-yl)deca-2,7-dienal
-
-
(2R)-2-[(3E,7E)-9-(hydroxymethyl)-4,8,11-trimethyldodeca-3,7,10-trien-1-yl]-2,8-dimethyl-3,4-dihydro-2H-chromen-6-ol
-
-
(2R,3R,4S,6E)-2-amino-1,3-dihydroxy-16-methylheptadec-6-en-4-yl hydrogen sulfate
-
(2S,7E)-9-(2,5-dihydroxyphenyl)-7-methyl-1-[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]non-7-en-2-yl sulfate
-
-
(3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5-dihydroxyphenyl)methanone
-
-
(4R,5R)-4-[(2E)-5-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2-methylpent-2-en-1-yl]-2-methyl-5-(2-methylprop-1-en-1-yl)cyclopent-2-en-1-one
-
-
(4S,5bR,11aS,13aS,13bR)-4-hydroxy-5b,8,8,11a,13a-pentamethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(4S,5bS,11aR,13aS,13bR)-11a-formyl-4-hydroxy-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(4S,5bS,11aR,13aS,13bR)-11a-[(acetyloxy)methyl]-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1,4-diyl diacetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(5bR,7aS,11aR,11bS,13R,13aS,13bS)-1-hydroxy-11a-(hydroxymethyl)-5b,8,8,13a-tetramethyl-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-13-yl acetate
-
(5bR,7aS,11aS,11bR,13R,13aS,13bR)-1-methoxy-5b,8,8,11a,13a-pentamethyl-3-oxo-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-13-yl acetate
-
(5bS,11aR,13aS,13bR)-11a-(hydroxymethyl)-5b,8,8,13a-tetramethyl-3-oxo-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(5E)-5-[(2R,6E,10E)-13-furan-3-yl-2,6,10-trimethyltrideca-6,10-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
-
linear furanosesterterpene, isolated from Smenospongia sp.
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(3-methoxybenzylidene)furan-2(5H)-one
-
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(4-methoxybenzylidene)furan-2(5H)-one
i.e. cadiolide H, purified from the ascidian Synoicum sp.
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)furan-2(5H)-one
i.e. cadiolide E, purified from the ascidian Synoicum sp.
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-[(2,4-dibromo-3-hydroxyphenyl)methylidene]furan-2(5H)-one
-
(5Z)-5-(3-bromo-4-hydroxybenzylidene)-4-(3-bromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]furan-2(5H)-one
i.e. cadiolide G, purified from the ascidian Synoicum sp.
(5Z)-5-[(2R,5Z,9Z)-13-furan-3-yl-2,6,10-trimethyltrideca-5,9-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
-
linear furanosesterterpene, isolated from Smenospongia sp.
(E)-2-(3-methylnon-2-enyl)benzene-1,4-diol
-
-
(E)-2-(4-hydroxy-3-methylbut-2-enyl)benzene-1,4-diol
-
-
(E)-2-(9-hydroxy-3-methylnon-2-enyl)benzene-1,4-diol
-
-
1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione
-
-
1-(2-aminoethyl)-1H-indol-6-ol
-
-
1-(3-methoxyphenyl)-2,3,4,4a,9,9a-hexahydro-1H-b-carboline
-
1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
-
-
1-(4-ethylpiperazin-1-yl)-3-nitropropan-1-one
-
-
1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
-
-
1-(5-hydroxy-1H-indol-3-yl)-2-(6-hydroxy-1H-indol-3-yl)ethane-1,2-dione
i.e. hyrtiosin B
1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-b-carboline
-
-
1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline
-
weak inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
1-cyclopropyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
-
1-cyclopropyl-6-fluoro-7-[4-([(3Z)-3-[2-(methoxycarbamothioyl)hydrazinylidene]-5-methyl-2-oxo-2,3-dihydro-1H-indol-1-yl]methyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
-
1-cyclopropyl-7-(3,5-dimethyl-4-(3-nitropropanoyl)piperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
-
1-cyclopropyl-7-[3,5-dimethyl-4-(3-nitropropanoyl)piperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
a fluoroquinolone derivative and structural analogue of succinate
1-ethyl-4-hydroxy-2-oxo-N'-tridecanoyl-1,2,3,4-tetrahydroquinoline-3-carbohydrazide
-
-
1-ethyl-6,8-difluoro-7-[3-methyl-4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
-
1-ethyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
-
12-deacetoxy-23-acetoxy-19-O-acetylscalarin
-
cytotoxic, isolated from Smenospongia sp.
12-deacetoxy-23-acetoxyscalarin
-
cytotoxic, isolated from Smenospongia sp.
12-deacetoxy-23-hydroxyheteronemin
-
cytotoxic, isolated from Smenospongia sp.
2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane
-
-
2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-hydroxymethyldiphenylmethane
-
-
2,2',3-tribromo-4,4',5,5'-tetrahydroxybibenzyl
-
-
2,2'-dibromo-4,4',5,5'-tetrahydroxybibenzyl
-
-
2,3-dibromo-4,5-dihydroxybenzyl alcohol
-
-
2,3-dibromo-4,5-dihydroxybenzyl methyl ether
-
-
2,5-dichloro-3-[(3E)-4-chloro-3-methylbut-3-en-1-yn-1-yl]-6-hydroxycyclohexa-2,5-diene-1,4-dione
2-(3-methylbut-2-enyl)benzene-1,4-diol
-
-
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
2-(4-hydroxyphenyl)-1-(5H-pyrido[4,3-b]indol-3-yl)ethan-1-one
-
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
2-allylbenzene-1,4-diol
-
-
2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone
-
-
2-methylidenebutanedioic acid
-
i.e. itaconate
2-[(2E,7R,8R)-7,8-dihydroxy-3-methyl-9-[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]non-2-en-1-yl]benzene-1,4-diol
-
-
3,4-dihydrohyrtiosulawesine
-
-
3,5-dibromo-4-hydroxyphenylethylamine
-
-
3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethylpyrocatechol
-
-
3-nitro-1-(4-phenylpiperazin-1-yl)propan-1-one
-
-
3-nitro-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one
-
-
4,4'-(hexane-1,1-diyl)bis(6-bromobenzene-1,3-diol)
-
4,4'-(oxydimethanediyl)bis(5,6-dibromobenzene-1,2-diol)
-
-
4,4'-ethane-1,2-diyldibenzene-1,2-diol
-
-
4,4'-methanediylbis(5,6-dibromobenzene-1,2-diol)
-
-
4,4'-methanediylbis(5-bromobenzene-1,2-diol)
-
-
4,4'-methylenebis(5,6-dibromobenzene-1,2-diol)
-
-
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4-chloromercuribenzoate
-
complete inactivation at 0.001 mM
4-cyclopropyl-6-[3,5-dimethyl-4-(4-nitro-2-oxobutyl)piperazin-1-yl]-7-fluoro-5-methoxy-1-oxo-1,4,7,8-tetrahydronaphthalene-2-carboxylic acid
-
-
4-hydroxy-9-deoxoidiadione
-
cytotoxic, linear furanosesterterpene, isolated from Smenospongia sp.
4-[2-hydroxy-2-(5H-pyrido[4,3-b]indol-3-yl)ethyl]phenol
-
4-[[1-(4-chlorophenyl)-5-(6-methoxynaphthalen-2-yl)-3-oxopentyl]amino]benzoic acid
-
-
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
5-bromo-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl N-prop-1-en-2-yl-L-phenylalaninate
-
-
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
5-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl pyrazine-2-carboxylate
-
-
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
5-hydroxy-1H-indole-3-carbaldehyde
-
-
5-hydroxy-1H-indole-3-carboxylic acid methyl ester
-
weak inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
5-hydroxyindole-3-carbaldehyde
-
moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
5-nitro-N'-[(E)-(5-nitrofuran-2-yl)methylidene]furan-2-carbohydrazide
-
-
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
6-hydroxy-4,9-dihydro-3H-beta-carboline-1-carboxylic acid
-
-
7-[3,5-dimethyl-4-[(5-nitro-2,6-dioxohexahydropyrimidin-4-yl)carbonyl]piperazin-1-yl]-1-ethyl-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
-
ascorbate
-
enzyme is inhibited by an ascorbate plus Fe2+ system under aerobic conditions,16% residual activity at 2 mM ascorbate/0.02 mM Fe2+. Inactivation requires hydrogen peroxide, and can be prevented by catalase, EDTA, Mg2+, isocitrate, 20 mM glutathione, 20 mM dithiothreitol or 40 mM L-cysteine
ATP
-
35% inhibition at 2 mM
bis(2,3-dibromo-4,5-dihydroxyphenyl) ether
-
-
bis(2,3-dibromo-4,5-dihydroxyphenyl)methanone
-
bis(2-bromo-4,5-dihydroxyphenyl) ether
-
-
bis(3,4-dihydroxyphenyl)methanone
-
-
bis(3-bromo-4,5-dihydroxyphenyl)methanone
-
-
Cu2+
-
isoforms ICL1 and ICL2 are 60-80% inhibited by 5 mM Cu2+
D-fructose-6-phosphate
-
-
D-Glucose-6-phosphate
-
-
dimethyl (2Z)-2-(3,5-dibromo-4-hydroxybenzoyl)-3-(3,5-dibromo-4-hydroxyphenyl)but-2-enedioate
i.e. synoilide A, purified from the ascidian Synoicum sp.
dimethyl (2Z)-2-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)but-2-enedioate
i.e. synoilide B, purified from the ascidian Synoicum sp.
fructose-1,6-bisphosphate
GSSG
-
ICL can be inactivated by glutathionylation and reactivated by glutaredoxin after reduced dithiothreitol treatment, whereas thioredoxin does not appear to regulate ICL activity
hyrtiosin A
-
moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
hyrtiosin B
-
strong inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
methyl (1R,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
methyl (1S,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate
methylmalonate
-
50% inhibition at 15 mM
Mg2+
-
isoform ICL2 is 20% inhibited by 5 mM Mg2+
N'1-[(4-nitrophenyl)methylene]-2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-1,2,3,4-tetrahydro-1-phthalazinyl]ethanohydrazide
-
is the most active compound
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
N-(4-bromo-3-methylphenyl)-3-nitropropanamide
-
-
N-(4-bromophenyl)-3-nitropropanamide
-
-
N-(4-chlorophenyl)-3-nitropropanamide
-
-
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
oxaloacetate
-
89% inhibition at 10 mM
p-hydroxymercuribenzoate
-
complete inhibition at 0.016 mM
serotonin
-
moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
sodium (2S)-5-furan-3-yl-2-[(1R)-1-hydroxy-2-[(1S,2R,4aR,8aR)-2-methyl-5-methylidenedecahydronaphthalen-1-yl]ethyl]pentyl sulfate
-
-
sodium 2,3-dihydroxypropyl (2R)-3-[[10-(2-hexylcyclopropyl)decanoyl]oxy]-2-hydroxypropyl phosphate
-
threo-DL-homoisocitrate
-
-
Urea
-
partial inactivation
XHD-1
-
extract of Illicium verum
-
XHD-2
-
extract of Zingiber officinale
-
[(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methanol
-
scarlarane sesterterpene, isolated from Smenospongia sp.
[(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methyl acetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
[(5bS,11aR,13aS,13bR)-1-methoxy-5b,8,8,13a-tetramethyl-1,5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a,13b-hexadecahydrochryseno[1,2-c]furan-11a(3H)-yl]methanol
-
scarlarane sesterterpene, isolated from Smenospongia sp.
2,5-dichloro-3-[(3E)-4-chloro-3-methylbut-3-en-1-yn-1-yl]-6-hydroxycyclohexa-2,5-diene-1,4-dione

-
-
2,5-dichloro-3-[(3E)-4-chloro-3-methylbut-3-en-1-yn-1-yl]-6-hydroxycyclohexa-2,5-diene-1,4-dione
-
-
2,5-dichloro-3-[(3E)-4-chloro-3-methylbut-3-en-1-yn-1-yl]-6-hydroxycyclohexa-2,5-diene-1,4-dione
-
-
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate

-
-
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
-
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
-
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole

-
-
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
-
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
-
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate

-
-
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
-
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
-
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole

-
-
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
-
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
-
2-mercaptoethanol

Candida brassicae
-
increase of activity
2-mercaptoethanol
-
increase of activity
2-oxoglutarate

-
-
2-oxoglutarate
-
19% inhibition at 5 mM
3-nitropropionate

-
0.133 mM, complete inhibition
3-nitropropionate
-
50% inhibition at 0.04 mM
3-nitropropionate
-
no growth of Mycobacterium tuberculosis on fatty acids after addition of 3-nitropropionate
3-nitropropionate
-
0.1 mM, inhibition of bacterial growth on and metabolisation of proprionate as sole carbon in absence of Vitamin B12
3-nitropropionate
-
a succinate analogue. Inhibition by 3-nitropropionate proceeds through an unusual double slow-onset process featuring formation of a complex with a Ki of 0.0033 mM during the first minute, followed by formation of a final complex with a Ki* of 44 nM over the course of several min to hours
3-nitropropionate
-
nearly complete inhibition at 6 mM
3-nitropropionate
-
irreversible inactivation
3-nitropropionic acid

-
-
3-nitropropionic acid
-
-
3-phosphoglycerate

-
-
3-phosphoglycerate
-
29% inhibition at 1 mM
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate

-
-
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
-
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
-
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide

-
-
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
-
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
-
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide

-
-
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
-
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
-
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide

-
-
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
-
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
-
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide

-
-
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
-
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
-
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide

-
-
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide

-
-
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide

-
-
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide

-
-
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide

-
-
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide

-
-
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole

-
-
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole

-
-
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole

-
-
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole

-
-
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate

-
-
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
-
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
-
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole

-
-
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide

-
-
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
-
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
-
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide

-
-
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
-
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
-
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide

-
-
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
-
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
-
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide

-
-
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
-
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
-
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide

-
-
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide

-
-
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide

-
-
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide

-
-
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide

-
-
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
-
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide

-
-
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
-
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole

-
-
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole

-
-
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole

-
-
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
-
ADP

-
20% inhibition at 2 mM
Ba2+

-
-
Ca2+

-
-
citrate

-
no inhibition at 0.1 mM
citrate
-
22% inhibition at 5 mM
Cl-

-
-
Fe2+

-
isoforms ICL1 and ICL2 are 30% inhibited by 5 mM Fe2+
Fe2+
-
enzyme is inhibited by an ascorbate plus Fe2+ system under aerobic conditions,16% residual activity at 2 mM ascorbate/0.02 mM Fe2+. Inactivation requires hydrogen peroxide, and can be prevented by catalase, EDTA, Mg2+, isocitrate, 20 mM glutathione, 20 mM dithiothreitol or 40 mM L-cysteine
fructose-1,6-bisphosphate

-
-
fructose-1,6-bisphosphate
-
39% inhibition at 5 mM
fructose-1,6-bisphosphate
-
-
fumarate

-
no inhibition at 0.1 mM
glucose-6-phosphate

-
44% inhibition at 5 mM
glutathione

Candida brassicae
-
increase of activity
glycolate

-
-
glycolate
Candida brassicae
-
-
glycolate
-
50% inhibition at 5 mM
glycolate
-
20% inhibition at 1 mM
glycolate
Lupinus sp.
-
-
glyoxylate

-
linear competitive inhibitor
glyoxylate
Lupinus sp.
-
-
H2O2

-
incubation with 0.1 mM H2O2 and 0.5mM GSH for 30 min results in a decrease of protein activity comparable with that obtained in the presence of GSSG. The addition of reduced dithiothreitol provides full reactivation of enzyme activity. Exposure to 1 mM H2O2 for 30 min results in an almost complete inactivation of the enzyme, whereas in the presence of a 10fold lower concentration of H2O2 (0.1 mM), ICL retains 20% of total activity after 30 min of incubation. GSH, reacting with sulfenic acid, can protect the protein from H2O2-mediated irreversible inactivation by glutathionylation
H2O2
-
inhibits enzyme activity with increased concentrations, no activity above 1.3 mM
HgCl2

-
100% inhibition at 0.01 mM
HgCl2
-
30% inhibition at 0.1 mM
HPO42-

-
-
Hydroxymalonate

-
-
Hydroxymalonate
-
50% inhibition at 0.5 mM
iodoacetate

-
isocitrate protects
iodoacetate
-
70% inhibition at 10 mM
Itaconate

-
-
Itaconate
-
89% inhibition at 1 mM
Itaconate
-
a succinate analogue lacking an acidic alpha-proton, the inhhibitor does not display slow-binding behavior
Itaconate
-
uncompetitive with respect to isocitrate
Itaconic acid

-
potent competitive inhibitor of ICL, 1 mg/ml reduces the activity to 42% of the uninhibited control. Inhibition of ICL enzymatic activity during chronic infection of rats forces the infection into an acute phase
Itaconic acid
-
itaconic acid specifically inhibits growth of wild-type cells on acetate and propionate, but not dextrose, in an ICL-dependent manner, and elicited metabolomic changes similar to those observed with ICL-deficient cells. Enzyme ICL inhibition by itaconic acid results in a specific decrease in intrabacterial pH from pH 7.3 to pH 6.4 in propionate-grown cells, not in acetate-grown cells
KCl

-
at pH-values above 8.6 inhibition, below pH 8.6 activation by KCl
KCl
-
strong activation by KCl
malate

-
no inhibition at 0.1 mM
malate
-
Icl enzyme, 50% inhibition at 5 mM
malate
-
competitive mode
Maleate

-
condensation reaction
Maleate
-
66% inhibition at 0.5 mM
malonate

-
-
malonate
-
condensation reaction
malonate
Candida brassicae
-
-
methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate

i.e. cadiolide I, purified from the ascidian Synoicum sp.
methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate
-
methylenesuccinate

-
-
methylenesuccinate
-
condensation reaction
methylenesuccinate
Lupinus sp.
-
-
methylenesuccinate
-
87% inhibition at 0.03 mM
Mn2+

-
isoform ICL1 is 40% inhibited by 5 mM Mn2+
Mn2+
Candida brassicae
-
inhibition in presence of Mg2+, activation in absence of Mg2+
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide

-
-
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
-
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
-
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide

-
-
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
-
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
-
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide

-
-
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
-
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
-
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide

-
-
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
-
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
-
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide

-
-
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
-
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
-
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide

-
-
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
-
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
-
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide

-
-
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
-
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
-
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide

-
-
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
-
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
-
N-ethylmaleimide

Lupinus sp.
-
-
N-ethylmaleimide
-
40% inhibition at 1 mM
NaCl

-
activation by NaCl
NO3-

-
-
oxalacetate

-
-
oxalacetate
-
50% inhibition at 5 mM
oxalate

-
-
oxalate
-
86% inhibition at 10 mM
oxalate
-
77% inhibition at 1 mM
oxalate
-
Icl enzyme, 50% inhibition at 5 mM
oxalate
-
71% inhibition at 0.5 mM
p-chloromercuribenzoate

-
100% inhibition at 0.02 mM, reversible by 2-mercaptoethanol
p-chloromercuribenzoate
Lupinus sp.
-
-
p-chloromercuribenzoate
-
reversible by cysteine
p-chloromercuribenzoate
-
70% inhibition at 0.1 mM
phosphate

-
-
phosphate
-
nonlinear competitive inhibitor, inhibition model
phosphoenolpyruvate

-
-
phosphoenolpyruvate
-
uncompetitive inhibitor
phosphoenolpyruvate
-
90% inhibition at 2 mM
phosphoenolpyruvate
Lupinus sp.
-
-
phosphoenolpyruvate
-
53% inhibition at 1 mM
pyruvate

-
-
pyruvate
-
58% inhibition at 5 mM
pyruvate
-
87% inhibition at 10 mM
SO42-

-
-
Sr2+

-
-
succinate

-
33% inhibition at 10 mM
succinate
Candida brassicae
-
-
succinate
-
21% inhibition at 5 mM
succinate
-
90% inhibition at 5 mM
succinate
-
38% inhibition at 1 mM
succinate
Lupinus sp.
-
-
succinate
-
AceA enzyme, 50% inhibition at 5 mM
succinate
-
competitive mode
succinate
-
7% inhibition at 0.5 mM
sulfhydryl compounds

-
increase of activity
sulfhydryl compounds
-
increase of activity
Tartrate

-
-
Tartrate
-
33% inhibition at 0.5 mM
Zn2+

-
isoforms ICL1 and ICL2 are 60-80% inhibited by 5 mM Zn2+
Zn2+
Candida brassicae
-
-
additional information

-
6-hydroxy-3,4-dihydro-1-oxo-beta-carboline, isolated from marine sponge Hyrtios sp. (Thorectidae family), defined inactive as inhibitor since IC50 is higher than 0.989 mM at a concentration of 2 mg/ml
-
additional information
-
natural glyoxylate cycle inhibitors such 5-hydroxyindole-type alkaloids are potent inhibitors
-
additional information
cadiolide and synoilide ICL inhibitors (5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)furan-2(5H)-one, (5Z)-5-(3-bromo-4-hydroxybenzylidene)-4-(3-bromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]furan-2(5H)-one, (5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(4-methoxybenzylidene)furan-2(5H)-one, methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate, dimethyl (2Z)-2-(3,5-dibromo-4-hydroxybenzoyl)-3-(3,5-dibromo-4-hydroxyphenyl)but-2-enedioate and dimethyl (2Z)-2-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)but-2-enedioate have no inhibitory effects on Candida albicans strain SC5314 grown in glucose, but are inhibitory to strain SC5314 grown in acetate
-
additional information
-
cadiolide and synoilide ICL inhibitors (5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)furan-2(5H)-one, (5Z)-5-(3-bromo-4-hydroxybenzylidene)-4-(3-bromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]furan-2(5H)-one, (5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(4-methoxybenzylidene)furan-2(5H)-one, methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate, dimethyl (2Z)-2-(3,5-dibromo-4-hydroxybenzoyl)-3-(3,5-dibromo-4-hydroxyphenyl)but-2-enedioate and dimethyl (2Z)-2-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)but-2-enedioate have no inhibitory effects on Candida albicans strain SC5314 grown in glucose, but are inhibitory to strain SC5314 grown in acetate
-
additional information
-
degradation of the aceA mRNA, encoding the enzyme, by RNase E/G, that cleaves the aceA mRNA at a single-stranded AU-rich region in the 3' untranslated region. The level of aceA mRNA is approximately 3fold higher in the rneG knockout mutant strain compared to the wild-type strain
-
additional information
-
reversible loss of activity in isocitrate lyase from Haloferax volcanii when the enzyme is out of extract without a thiol, such as dithiothreitol
-
additional information
-
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
-
additional information
-
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
-
additional information
-
some 2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazinyl]acetic acid hydrazones show 45-61% inhibition at 10 mM
-
additional information
-
extracts of Illicium verum and Zingiber officinale inhibit ICL
-
additional information
-
design, synthesis, inhibitory potencies against the enzyme, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
-
additional information
-
not inhibited by bromopyruvate
-
additional information
-
halisulfates from the tropical sponge Hippospongia sp. are able to inhibit ICL activity, appressorium formation and C2 utilization
-
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