Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | 15 min irradiation in the absence of peptide resulted in a 10% inactivation of the carboxylase | Bos taurus | |
proFIX/PT28 (Bpa +4) | presence of proFIX/PT28 (Bpa +4) or its iodinated derivative 56% inactivation is observed | Bos taurus | |
TVFLDHENANKILNRPKRANTBLEEVRK | the enzyme is photoirradiated on ice at 365 nm with TVFLDHENANKILNRPKRANTBLEEVRK, TVFLDHENANKILNRPKRYNTBLEEVRK and mono [127I]TVFLDHENANKILNRPKRYNTBLEEVRK for various times | Bos taurus | |
TVFLDHENANKILNRPKRYNTBLEEVRK | the enzyme is photoirradiated on ice at 365 nm with TVFLDHENANKILNRPKRANTBLEEVRK, TVFLDHENANKILNRPKRYNTBLEEVRK and mono [127I]TVFLDHENANKILNRPKRYNTBLEEVRK for various times. Presence of TVFLDHENANKILNRPKRYNTBLEEVRK or its iodinated derivative 80% inactivation is observed | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0068 | - |
TVFLDHENANKILNRPKRANTBLEEVRK | carboxylase probe1, TVFLDHENANKILNRPKRANTBLEEVRK as a substrate | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | Q07175 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FLEEV + CO2 + O2 + vitamin K hydroquinone | - |
Bos taurus | ? + vitamin K epoxide + H2O | - |
? | |
additional information | photolabeling of Q-glutamyl carboxylase with Bpa peptides | Bos taurus | ? | - |
? | |
proFIX 19 + CO2 + O2 + vitamin K hydroquinone | proFIX 19, peptide sequence: TVFLDHENANKILNRPKRY | Bos taurus | ? + vitamin K epoxide + H2O | - |
? | |
proFIX/PT28 + CO2 + O2 + vitamin K hydroquinone | proFIX/PT28, peptide sequence: TVFLDHENANKILNRPKRANTFLEEVRK | Bos taurus | ? + vitamin K epoxide + H2O | - |
? | |
TVFLDHENANKILNRPKRANTBLEEVRK + CO2 + O2 + vitamin K hydroquinone | carboxylase probe1, TVFLDHENANKILNRPKRANTBLEEVRK as a substrate | Bos taurus | ? + vitamin K epoxide + H2O | - |
? | |
TVFLDHENANKILNRPKRYNTBLEEVRK + CO2 + O2 + vitamin K hydroquinone | - |
Bos taurus | ? + vitamin K epoxide + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | limited tryptic digestion of the carboxylase yields two disulfide-linked fragments with molecular masses of 30 and 60 kDa, corresponding to the amino and carboxy-terminal part of the gamma-glutamyl carboxylase | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
gamma-glutamyl carboxylase | - |
Bos taurus |
glutamate carboxylase | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
vitamin K | - |
Bos taurus |