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Information on EC - peptidyl-glutamate 4-carboxylase

for references in articles please use BRENDA:EC4.1.1.90
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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
       peptidyl-glutamate 4-carboxylase
IUBMB Comments
The enzyme can use various vitamin-K derivatives, including menaquinol, but does not contain iron. The mechanism appears to involve the generation of a strong base by oxygenation of vitamin K. It catalyses the post-translational carboxylation of glutamate residues of several proteins of the blood-clotting system. 9--12 glutamate residues are converted to 4-carboxyglutamate (Gla) in a specific domain of the target protein. The 4-pro-S hydrogen of the glutamate residue is removed and there is an inversion of stereochemistry at this position .
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
carboxylase, Ci-GGC, gamma glutamyl carboxylase, gamma-carboxylase, gamma-glutamyl carboxylase, GGCX, glutamate carboxylase, matrix gamma-carboxyglutamate protein, matrix Gla protein, peptidyl-glutamate 4-carboxylase, more
peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O = peptidyl-glutamate + CO2 + O2 + phylloquinol
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