Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | a decrease in urinary levels of dopamine and in renal AADC activity at 20 twenty-six weeks after renal mass ablation | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.2 | - |
L-3,4-dihydroxyphenylalanine | determined in homogenates of renal cortex of 3/4 nephrectomized rats after 26 weeks | Rattus norvegicus | |
2.6 | - |
L-3,4-dihydroxyphenylalanine | determined in homogenates of renal cortex of sham surgery rats (control) after 10 weeks | Rattus norvegicus | |
2.6 | - |
L-3,4-dihydroxyphenylalanine | determined in homogenates of renal cortex of sham surgery rats (control) after 26 weeks | Rattus norvegicus | |
2.9 | - |
L-3,4-dihydroxyphenylalanine | determined in homogenates of renal cortex of 3/4 nephrectomized rats after 10 weeks | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-3,4-Dihydroxyphenylalanine | Rattus norvegicus | the renal dopaminergic system is highly dynamic and the basic mechanisms for the regulation of this system mainly depends on the availability of L-dopa, its fast decarboxylation into dopamine, precise cell outward amine transfer mechanisms, dopamine interaction with specific receptor and accurate intracellular signal transduction | Dopamine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
normotensive male Wistar-Han rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | renal dopaminergic system activity in rat (3/4 nephrectomized) kidney up to 26 weeks after surgery | Rattus norvegicus | - |
proximale tubular epithelium | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00000113 | - |
determined in homogenates of renal cortex of 3/4 nephrectomized rats after 26 weeks | Rattus norvegicus |
0.00001427 | - |
determined in homogenates of renal cortex of sham surgery rats (control) after 10 weeks | Rattus norvegicus |
0.00001653 | - |
determined in homogenates of renal cortex of sham surgery rats (control) after 26 weeks | Rattus norvegicus |
0.00001893 | - |
determined in homogenates of renal cortex of 3/4 nephrectomized rats after 10 weeks | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-3,4-Dihydroxyphenylalanine | the renal dopaminergic system is highly dynamic and the basic mechanisms for the regulation of this system mainly depends on the availability of L-dopa, its fast decarboxylation into dopamine, precise cell outward amine transfer mechanisms, dopamine interaction with specific receptor and accurate intracellular signal transduction | Rattus norvegicus | Dopamine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AADC | - |
Rattus norvegicus |
Aromatic L-amino acid decarboxylase | - |
Rattus norvegicus |