BRENDA - Enzyme Database show
show all sequences of 3.6.1.9

Structural and functional comparisons of nucleotide pyrophosphatase/phosphodiesterase and alkaline phosphatase: implications for mechanism and evolution

Zalatan, J.G.; Fenn, T.D.; Brunger, A.T.; Herschlag, D.; Biochemistry 45, 9788-9803 (2006)

Data extracted from this reference:

Crystallization (Commentary)
Crystallization
Organism
in absence of ligands and in complex with vanadate or AMP. Comparison of bimetallo active site with Escherichia coli alkaline phosphatase
Mus musculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
substrate methyl 4-nitrophenyl phosphate, KM-value greater than 2 mM, substrate bis-4-nitrophenyl phosphate, KM-value greater than 1 mM
Mus musculus
0.11
-
p-nitrophenyl 5'-thymidine monophosphate
25°C, pH 8.0
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-nitrophenyl phosphate dianion + H2O
-
667745
Mus musculus
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate monoanion + H2O
72fold higher activity than with 4-nitrophenyl phosphate dianion
667745
Mus musculus
4-nitrophenol + phosphate
-
-
-
?
bis-4-nitrophenyl phosphate + H2O
2000fold higher activity than with 4-nitrophenyl phosphate dianion
667745
Mus musculus
4-nitrophenol + phosphate
-
-
-
?
methyl 4-nitrophenyl phosphate + H2O
200fold higher activity than with 4-nitrophenyl phosphate dianion
667745
Mus musculus
4-nitrophenol + methyl phosphate
-
-
-
?
p-nitrophenyl 5'-thymidine monophosphate + H2O
1500000fold higher activity than with 4-nitrophenyl phosphate dianion
667745
Mus musculus
4-nitrophenol + TMP
-
-
-
?
Crystallization (Commentary) (protein specific)
Crystallization
Organism
in absence of ligands and in complex with vanadate or AMP. Comparison of bimetallo active site with Escherichia coli alkaline phosphatase
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
substrate methyl 4-nitrophenyl phosphate, KM-value greater than 2 mM, substrate bis-4-nitrophenyl phosphate, KM-value greater than 1 mM
Mus musculus
0.11
-
p-nitrophenyl 5'-thymidine monophosphate
25°C, pH 8.0
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-nitrophenyl phosphate dianion + H2O
-
667745
Mus musculus
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate monoanion + H2O
72fold higher activity than with 4-nitrophenyl phosphate dianion
667745
Mus musculus
4-nitrophenol + phosphate
-
-
-
?
bis-4-nitrophenyl phosphate + H2O
2000fold higher activity than with 4-nitrophenyl phosphate dianion
667745
Mus musculus
4-nitrophenol + phosphate
-
-
-
?
methyl 4-nitrophenyl phosphate + H2O
200fold higher activity than with 4-nitrophenyl phosphate dianion
667745
Mus musculus
4-nitrophenol + methyl phosphate
-
-
-
?
p-nitrophenyl 5'-thymidine monophosphate + H2O
1500000fold higher activity than with 4-nitrophenyl phosphate dianion
667745
Mus musculus
4-nitrophenol + TMP
-
-
-
?
Other publictions for EC 3.6.1.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735007
Jin
Insights into the cellular fun ...
Escherichia coli
PLoS ONE
10
e0117823
2015
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5
1
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2
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2
2
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2
2
730589
Kaneko
Nucleotide pyrophosphatase/pho ...
Oryza sativa
Plant Cell Physiol.
55
320-332
2014
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1
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1
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27
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1
6
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6
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7
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32
1
2
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27
3
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3
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1
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27
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3
6
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11
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32
3
3
-
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28
3
-
-
-
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2
2
-
28
28
733574
Duan
Changes of activity and isofor ...
Homo sapiens
BMC Gastroenterol.
14
138
2014
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1
1
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1
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1
-
-
734782
Greiner-Tollersrud
The non-classical N-glycan pro ...
Bos taurus
Neurochem. Res.
39
2025-2029
2014
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1
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1
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2
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1
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-
-
718817
Jaemsen
Fast kinetics of nucleotide bi ...
Clostridium perfringens
Biochemistry (Moscow)
77
165-170
2012
5
-
-
-
-
-
2
1
-
4
-
-
-
3
-
-
-
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-
-
-
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-
-
1
-
-
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1
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5
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2
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1
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4
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1
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1
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1
1
-
-
-
719660
Hou
QM/MM analysis suggests that a ...
Escherichia coli, Xanthomonas citri, Xanthomonas citri 306
J. Am. Chem. Soc.
134
229-246
2012
-
-
-
-
4
-
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4
-
3
-
3
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3
2
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4
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4
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3
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3
2
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2
2
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-
720117
Pochmann
Biochemical characterization o ...
Rattus norvegicus, Rattus norvegicus Wistar
J. Enzyme Inhib. Med. Chem.
27
29-36
2012
-
-
-
-
-
-
3
2
2
1
-
-
-
167
-
-
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1
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2
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1
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2
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3
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2
1
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1
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2
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1
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-
2
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1
1
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-
-
733430
Poulsen
Characterization of human phos ...
Homo sapiens
Biochimie
94
1098-1107
2012
-
-
-
-
-
-
-
-
1
-
1
1
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1
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1
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1
1
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1
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1
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1
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1
1
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-
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-
-
-
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-
-
-
-
718664
Joye
Mutational analysis of wheat ( ...
Triticum aestivum
Appl. Microbiol. Biotechnol.
90
173-180
2011
-
-
1
-
9
-
-
-
1
1
-
-
-
3
-
-
1
-
-
-
-
-
9
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
9
-
-
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-
1
1
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1
-
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-
-
9
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
719535
Spano
Purification and characterisat ...
Opuntia ficus-indica
Food Res. Int.
44
2264-2270
2011
-
-
-
-
-
-
1
5
1
2
2
4
-
1
-
1
1
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1
1
-
6
1
1
-
1
5
1
1
-
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-
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1
-
5
1
2
2
4
-
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1
1
-
1
1
-
6
1
1
-
1
5
1
1
-
-
-
1
1
-
-
-
712252
Lopez-Canut
Theoretical study of phosphodi ...
Xanthomonas citri
J. Am. Chem. Soc.
132
6955-6963
2010
-
-
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-
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1
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1
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1
1
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1
1
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-
712487
Simao
Proteoliposomes harboring alka ...
Mus musculus
J. Biol. Chem.
285
7598-7609
2010
-
-
1
-
-
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1
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1
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1
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6
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1
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1
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1
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6
-
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-
-
-
-
-
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-
712923
Buffon
Differential expression of nuc ...
Rattus norvegicus
Life Sci.
86
435-440
2010
-
-
-
-
-
-
1
-
-
1
-
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1
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2
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1
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1
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1
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2
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
713008
Laketa
Biochemical characterization o ...
Rattus norvegicus
Mol. Cell. Biochem.
339
99-106
2010
-
-
-
-
-
-
8
1
1
-
-
-
-
2
-
-
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1
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1
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1
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8
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1
1
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1
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1
-
-
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1
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1
1
-
-
-
720099
Joye
Characterisation of the first ...
Triticum aestivum
J. Cereal Sci.
51
326-336
2010
-
-
1
-
-
-
3
1
1
1
-
-
-
1
-
-
1
-
-
-
1
-
10
1
1
-
2
-
1
-
1
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1
-
-
-
-
-
3
-
1
1
1
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1
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1
-
10
1
1
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2
-
1
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1
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-
-
-
-
-
720186
Eliahu
Diadenosine 5,5-(boranated)pol ...
Homo sapiens
J. Med. Chem.
53
8485-8497
2010
-
-
1
-
-
-
5
-
1
2
-
3
-
4
-
-
-
-
-
2
-
-
23
-
1
-
-
-
1
-
-
-
4
-
4
-
-
3
-
-
-
-
4
15
4
-
3
6
-
3
-
-
-
-
-
6
-
-
23
-
3
-
-
-
3
-
-
-
-
1
3
-
-
-
711034
Henz
Influence of antidepressant dr ...
Rattus norvegicus
Arch. Oral Biol.
54
730-736
2009
-
-
-
-
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-
1
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3
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3
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2
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2
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1
-
-
2
-
-
713555
Santoro
NPP-BJ, a nucleotide pyrophosp ...
Bothrops jararaca
Toxicon
54
499-512
2009
-
-
-
-
-
-
4
2
-
-
1
-
-
1
-
-
1
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1
6
-
21
-
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2
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4
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2
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1
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1
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1
6
-
21
-
-
-
-
2
-
-
-
-
-
1
1
-
1
1
696406
Yegutkin
Nucleotide- and nucleoside-con ...
Homo sapiens
Biochim. Biophys. Acta
1783
673-694
2008
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1
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2
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1
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7
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2
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7
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2
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696924
Fuerstenau
Ectonucleotidase activities ar ...
Rattus norvegicus
Blood Cells Mol. Dis.
41
223-229
2008
-
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1
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4
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1
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697554
Keene
Association of the distal regi ...
Homo sapiens
Diabetes
57
1057-1062
2008
-
1
-
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1
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1
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1
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1
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697602
Iqbal
A highly sensitive CE-UV metho ...
Homo sapiens
Electrophoresis
29
3685-3693
2008
-
-
1
-
-
-
2
2
1
-
-
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1
-
1
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-
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3
-
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4
-
4
-
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1
-
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4
2
4
2
1
-
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-
-
1
-
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-
-
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3
-
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-
698337
Cognato
Expression mapping of ectonucl ...
Rattus norvegicus
Int. J. Dev. Neurosci.
26
593-598
2008
1
-
-
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1
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1
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4
-
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6
-
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1
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1
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2
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12
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-
667745
Zalatan
Structural and functional comp ...
Mus musculus
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1
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10
2
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2
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1
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2
2
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1
-
-
10
2
-
-
2
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-
246817
Bartkiewicz
Nucleotide pyrophosphatase fro ...
Solanum tuberosum
Eur. J. Biochem.
143
419-426
1984
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-
-
-
-
-
10
12
-
-
2
10
-
4
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1
1
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-
3
1
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26
1
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10
-
12
-
-
2
10
-
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1
1
-
3
1
-
26
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
246818
Rossomando
Solubilization and substrate s ...
Dictyostelium discoideum
J. Biol. Chem.
258
7653-7660
1983
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-
-
-
-
-
3
5
1
1
-
4
-
1
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1
-
-
1
-
-
10
-
1
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1
-
1
-
1
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-
-
-
-
-
-
3
1
5
1
1
-
4
-
-
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1
-
1
-
-
10
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
246819
Buckon
Studies of bovine seminal flui ...
Bos taurus
Arch. Biochem. Biophys.
202
396-404
1980
1
-
-
-
-
-
3
5
-
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2
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1
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1
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1
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4
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1
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1
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2
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1
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3
2
5
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2
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1
-
1
-
-
4
-
-
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1
-
1
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-
-
-
246820
Pellon
Identification d'une nucleotid ...
Amycolatopsis mediterranei, Amycolatopsis mediterranei ME/R17
Can. J. Microbiol.
25
53-60
1979
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-
-
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2
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6
-
2
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1
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6
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2
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6
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1
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6
-
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-
246821
Twu
Nucleotide pyrophosphatase fro ...
Saccharomyces cerevisiae
Arch. Biochem. Biophys.
184
249-256
1977
-
-
-
-
-
-
6
-
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1
-
2
-
1
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1
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3
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6
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1
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2
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1
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-
3
-
-
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-
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-
-
-
246822
Balakrishnan
Studies on nucleotidases in pl ...
Vigna radiata var. radiata
Eur. J. Biochem.
78
95-102
1977
-
-
-
-
-
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5
3
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-
3
1
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1
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1
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1
2
2
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1
-
1
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5
-
3
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3
1
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1
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1
2
2
-
1
-
1
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-
-
-
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-
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246823
Abney
Location of nucleotide pyropho ...
Mus musculus
Biochem. J.
159
293-299
1976
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-
-
-
-
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1
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1
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1
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2
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1
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1
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1
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2
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1
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246824
Kole
Novel activity of potato nucle ...
Solanum tuberosum
Biochim. Biophys. Acta
438
540-550
1976
-
-
-
-
-
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5
6
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4
-
3
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1
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1
1
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16
-
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1
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1
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-
2
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-
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5
2
6
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-
4
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1
-
1
1
-
16
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
246825
Bischof
-
Nucleotide pyrophosphatase of ...
Rattus sp.
Eur. J. Biochem.
51
3535-361
1975
-
-
-
-
-
-
5
6
3
2
1
5
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1
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1
1
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1
1
1
7
1
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1
-
1
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-
-
-
-
-
-
-
5
-
6
3
2
1
5
-
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1
1
-
1
1
1
7
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
246826
Balakrishnan
Studies on nucleotidases in pl ...
Vigna radiata var. radiata
Arch. Biochem. Biophys.
164
156-164
1974
-
-
-
-
-
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7
4
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-
2
-
1
-
-
-
-
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-
-
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2
-
1
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1
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7
-
4
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2
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-
2
-
1
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1
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246827
Evans
Purification and properties of ...
Mus musculus
Biochem. J.
135
819-826
1973
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-
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1
3
1
1
2
1
5
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1
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1
1
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1
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6
1
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1
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1
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-
1
-
3
1
1
1
2
1
5
-
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1
1
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1
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-
6
1
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1
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246828
Haroz
Purification and properties of ...
Saccharomyces sp.
J. Biol. Chem.
247
1452-1457
1972
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-
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8
4
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-
2
8
-
1
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1
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1
1
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11
1
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-
1
1
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-
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-
-
-
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8
-
4
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2
8
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1
-
1
1
-
11
1
-
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1
1
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-
-
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-
246829
Krishnan
Studies on nucleotide pyrophos ...
Ovis aries aries
Arch. Biochem. Biophys.
149
336-348
1972
1
-
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-
1
16
1
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-
3
-
1
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-
1
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1
1
1
3
-
3
-
-
-
1
-
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1
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-
1
-
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-
-
1
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16
1
1
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-
3
-
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-
1
-
1
1
1
3
-
3
-
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-
1
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-
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246830
Decker
Purification and properties of ...
Rattus sp.
FEBS Lett.
21
95-98
1972
-
-
-
-
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5
4
1
2
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8
-
1
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1
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1
1
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9
-
-
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-
1
-
1
-
1
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-
-
-
-
-
-
-
-
-
5
1
4
1
2
-
8
-
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1
-
1
1
-
9
-
-
-
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1
-
1
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-
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-
246831
Bachorik
The purification and propertie ...
Rattus sp.
J. Biol. Chem.
247
5071-5078
1972
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-
-
-
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6
4
1
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8
-
1
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1
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1
1
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10
-
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1
-
1
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6
-
4
1
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8
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1
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1
1
-
10
-
-
-
-
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1
-
1
-
-
-
-
-
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-
246832
Swartz
A 'heat-activated' diphosphopy ...
Proteus vulgaris
J. Biol. Chem.
232
1051-1063
1958
-
-
-
-
-
-
-
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1
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2
-
2
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1
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1
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2
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1
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1
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2
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1
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1
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2
-
-
-
1
-
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246833
Jacobson
A reduced pyridine nucleotide ...
Columba livia
J. Biol. Chem.
226
427-437
1957
-
-
-
-
-
-
7
1
-
1
-
6
-
1
-
-
1
-
-
1
-
1
9
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
7
-
1
-
1
-
6
-
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-
1
-
1
-
1
9
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
246834
Kornberg
-
Nucleotide pyrophosphatase ...
Solanum tuberosum
J. Biol. Chem.
182
763-778
1950
-
-
-
-
-
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6
-
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5
-
1
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1
-
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1
1
1
5
-
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1
-
2
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-
-
-
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-
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6
-
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-
5
-
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-
1
-
1
1
1
5
-
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1
-
2
-
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-