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Literature summary for 3.6.1.9 extracted from

  • Bachorik, P.S.; Dietrich, L.S.
    The purification and properties of detergent-solubilized rat liver nucleotide pyrophosphatase (1972), J. Biol. Chem., 247, 5071-5078.
    View publication on PubMed
Search for more literature for 3.6.1.9

Inhibitors

Inhibitors Comment Organism Structure
5'-AMP 29% inhibition at 12 mM Rattus sp.
dAMP 16% inhibition at 17 mM Rattus sp.
diphosphate 26% inhibition at 10 mM Rattus sp.
EDTA 50% inhibition at 1 mM Rattus sp.
NaF 22% inhibition at 45 mM Rattus sp.
UMP 11% inhibition at 56 mM Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.6
-
 NADH
-
 Rattus sp.
14.9
-
 UDP-glucose
-
 Rattus sp.
18.9
-
 ADP-ribose
-
 Rattus sp.
31.2
-
 NAD+
-
 Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus sp. 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP-ribose + H2O Rattus sp.
-
 AMP + phosphoribose
-
 ?
ATP + H2O Rattus sp.
-
 AMP + diphosphate
-
 ?
NAD+ + H2O Rattus sp.
-
 NMN + AMP
-
 ?
NADH + H2O Rattus sp.
-
 NMNH + AMP
-
 ?
NADPH + H2O Rattus sp.
-
 NMNH + adenosine 2',5'-phosphate
-
 ?
UDP-glucose + H2O Rattus sp.
-
 UMP + D-glucose-1-phosphate
-
 ?
UDP-glucuronic acid + H2O Rattus sp.
-
 UMP + glucuronic acid phosphate
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + H2O Rattus sp.
-
 UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus sp.

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
9.1
-
-
 Rattus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP-ribose + H2O
-
 Rattus sp. AMP + phosphoribose
-
 ?
ATP + H2O
-
 Rattus sp. AMP + diphosphate
-
 ?
bis(p-nitrophenyl)phosphate + H2O 0.31% hydrolysis rate compared to NADH as substrate Rattus sp. p-nitrophenol + p-nitrophenylphosphate
-
 ?
NAD+ + H2O
-
 Rattus sp. NMN + AMP
-
 ?
NADH + H2O
-
 Rattus sp. NMNH + AMP
-
 ?
NADPH + H2O
-
 Rattus sp. NMNH + adenosine 2',5'-phosphate
-
 ?
p-nitrophenylphosphate + H2O 0.04% hydrolysis rate compared to NADH as substrate Rattus sp. p-nitrophenol + phosphate
-
 ?
UDP-glucose + H2O
-
 Rattus sp. UMP + D-glucose-1-phosphate
-
 ?
UDP-glucuronic acid + H2O
-
 Rattus sp. UMP + glucuronic acid phosphate
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + H2O
-
 Rattus sp. UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
 Rattus sp.

pH Stability

pH Stability pH Stability Maximum Comment Organism
6 9 completely stable between, less stable at lower pH Rattus sp.