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Literature summary for 3.6.1.56 extracted from

  • Fujikawa, K.; Kamiya, H.; Yakushiji, H.; Nakabeppu, Y.; Kasai, H.
    Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP (2011), Nucleic Acids Res., 29, 449-454.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.56

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0043
-
 2-hydroxy-ATP pH 8.0, 30°C Homo sapiens
0.0083
-
 2-hydroxy-dATP pH 8.0, 30°C Homo sapiens
0.0139
-
 8-oxo-dATP pH 8.0, 30°C Homo sapiens
0.0152
-
 8-oxo-dGTP pH 8.0, 30°C Homo sapiens
0.051
-
 8-oxo-ATP pH 8.0, 30°C Homo sapiens
0.055
-
 8-oxo-GTP pH 8.0, 30°C Homo sapiens
0.258
-
 dGTP pH 8.0, 30°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxy-ATP + H2O
-
 Homo sapiens 2-hydroxy-AMP + diphosphate
-
 ?
2-hydroxy-dATP + H2O is more efficiently hydrolyzed to the monophosphate than is 8-oxo-dGTP Homo sapiens 2-hydroxy-dAMP + diphosphate
-
 ?
8-oxo-ATP + H2O
-
 Homo sapiens 8-oxo-AMP + diphosphate poor substrate ?
8-oxo-dATP + H2O
-
 Homo sapiens 8-oxo-dAMP + diphosphate
-
 ?
8-oxo-dGTP + H2O this enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP Homo sapiens 8-oxo-dGMP + diphosphate
-
 ?
8-oxo-GTP + H2O poor substrate Homo sapiens 8-oxo-GMP + diphosphate
-
 ?
dGTP + H2O poor substrate Homo sapiens dGMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
MTH1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 asay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1
-
 8-oxo-ATP pH 8.0, 30°C Homo sapiens
2.6
-
 8-oxo-GTP pH 8.0, 30°C Homo sapiens
4.7
-
 2-hydroxy-ATP pH 8.0, 30°C Homo sapiens
10.8
-
 8-oxo-dATP pH 8.0, 30°C Homo sapiens
12.3
-
 8-oxo-dGTP pH 8.0, 30°C Homo sapiens
13.9
-
 2-hydroxy-dATP pH 8.0, 30°C Homo sapiens
15.7
-
 dGTP pH 8.0, 30°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
22
-
 8-oxo-ATP pH 8.0, 30°C Homo sapiens
47
-
 8-oxo-GTP pH 8.0, 30°C Homo sapiens
60
-
 dGTP pH 8.0, 30°C Homo sapiens
780
-
 8-oxo-dATP pH 8.0, 30°C Homo sapiens
810
-
 8-oxo-dGTP pH 8.0, 30°C Homo sapiens
1093
-
 2-hydroxy-ATP pH 8.0, 30°C Homo sapiens
1680
-
 2-hydroxy-dATP pH 8.0, 30°C Homo sapiens