BRENDA - Enzyme Database show
show all sequences of 3.6.1.22

Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities

Bortell, R.; Moss, J.; McKenna, R.C.; Rigby, M.R.; Niedzwiecki, D.; Stevens, L.A.; Patton, W.A.; Mordes, J.P.; Greiner, D.L.; Rossini, A.A.; J. Immunol. 167, 2049-2059 (2001)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
enzyme may serve a regulatory role in modifying the inhibitory effect of ecto-NAD on T-cell activation
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cell surface
-
Rattus norvegicus
9986
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Rattus norvegicus
enzyme may serve a regulatory role in modifying the inhibitory effect of ecto-NAD on T-cell activation
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
T-lymphocyte
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
enzyme may serve a regulatory role in modifying the inhibitory effect of ecto-NAD on T-cell activation
656433
Rattus norvegicus
?
-
-
-
-
Application (protein specific)
Application
Commentary
Organism
medicine
enzyme may serve a regulatory role in modifying the inhibitory effect of ecto-NAD on T-cell activation
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cell surface
-
Rattus norvegicus
9986
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Rattus norvegicus
enzyme may serve a regulatory role in modifying the inhibitory effect of ecto-NAD on T-cell activation
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
T-lymphocyte
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
enzyme may serve a regulatory role in modifying the inhibitory effect of ecto-NAD on T-cell activation
656433
Rattus norvegicus
?
-
-
-
-
Other publictions for EC 3.6.1.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733748
Wang
Identification of UshA as a ma ...
Escherichia coli, Escherichia coli DH10B
Enzyme Microb. Technol.
58-59
75-79
2014
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1
1
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3
3
720498
Wang
Comparative analysis of mycoba ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis variant bovis
Mol. Microbiol.
82
1375-1391
2011
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670632
Jambunathan
Analysis of Arabidopsis growth ...
Arabidopsis sp.
Planta
224
1-11
2006
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668217
Magni
Enzymology of NAD+ homeostasis ...
Homo sapiens
Cell. Mol. Life Sci.
61
19-34
2004
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654332
AbdelRaheim
The NADH diphosphatase encoded ...
Saccharomyces cerevisiae
Arch. Biochem. Biophys.
388
18-24
2001
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1
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655747
Schmidt-Brauns
Is a NAD pyrophosphatase activ ...
Haemophilus influenzae
Int. J. Med. Microbiol.
291
219-225
2001
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656433
Bortell
Nicotinamide adenine dinucleot ...
Rattus norvegicus
J. Immunol.
167
2049-2059
2001
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209959
Xu
Cloning and characterization o ...
Caenorhabditis elegans, Escherichia coli, Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
273
753-758
2000
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209958
Hagen
Detection and identification o ...
Rattus norvegicus
Biochim. Biophys. Acta
1340
7-12
1997
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209957
Frick
Cloning, purification, and pro ...
Escherichia coli
J. Biol. Chem.
270
1529-1534
1995
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171771
Wagner
The pyridine-nucleotide cycle ...
Nicotiana tabacum
Planta
167
226-232
1986
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171772
Wagner
Regulation in tobacco callus o ...
Nicotiana tabacum
Planta
168
408-413
1986
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209954
Falconer
-
Membrane association of NAD py ...
Salmonella enterica subsp. enterica serovar Typhimurium
Curr. Microbiol.
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237-242
1984
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171773
Foster
Pyridine nucleotide cycle of S ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Bacteriol.
145
1002-1009
1981
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209952
Berghaeuser
-
A simple preparation of an enz ...
Solanum tuberosum
Biotechnol. Lett.
3
339-344
1981
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209951
Davies
An enzyme degrading reduced ni ...
Proteus vulgaris
Biochem. J.
175
669-674
1978
1
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Jeck
Simple methods of preparing ni ...
Solanum tuberosum
FEBS Lett.
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209949
Nakajima
Purification and properties of ...
Proteus vulgaris
Biochim. Biophys. Acta
293
242-255
1973
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209948
Anderson
Nicotinamide-adenin dinucleoti ...
Aedes aegypti
Biochem. J.
101
392-396
1966
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