Literature summary for 3.5.4.38 extracted from

Shi, K.; Demir, O.e.; Carpenter, M.A.; Wagner, J.; Kurahashi, K.; Harris, R.S.; Amaro, R.E.; Aihara, H.
Conformational switch regulates the DNA cytosine deaminase activity of human APOBEC3B (2017), Sci. Rep., 7, 17415 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cytosine in single-stranded DNA + H2O	Homo sapiens	conformational equilibrium of the APOBEC3B active site loops, skewed toward being closed, controls enzymatic activity by regulating binding to ssDNA substrates	uracil in single-stranded DNA + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UH17	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cytosine in single-stranded DNA + H2O	-	Homo sapiens	uracil in single-stranded DNA + NH3	-	?
cytosine in single-stranded DNA + H2O	conformational equilibrium of the APOBEC3B active site loops, skewed toward being closed, controls enzymatic activity by regulating binding to ssDNA substrates	Homo sapiens	uracil in single-stranded DNA + NH3	-	?

Synonyms

Synonyms	Comment	Organism
APOBEC3B	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme has important roles in innate immunity but is also a major endogenous source of mutations in cancer	Homo sapiens

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Release 2023.1 (January 2023)