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Information on EC 3.5.4.38 - single-stranded DNA cytosine deaminase

for references in articles please use BRENDA:EC3.5.4.38
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IUBMB Comments
The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) . The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
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Word Map
  • 3.5.4.38
  • hypermutation
  • deamination
  • ige
  • diversification
  • uracil
  • cytidine
  • class-switching
  • glycosylase
  • aid-induced
  • uracil-dna
  • aid-mediated
  • deaminases
  • aid-dependent
  • r-loops
  • abasic
  • rna-editing
  • aid-initiated
  • apobec1
  • non-ig
  • aid-deficient
The expected taxonomic range for this enzyme is: Tetrapoda
Reaction Schemes
cytosine in single-stranded DNA
+
=
uracil in single-stranded DNA
+
Synonyms
activation-induced deaminase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3
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