Literature summary for 3.5.4.38 extracted from

King, J.J.; Manuel, C.A.; Barrett, C.V.; Raber, S.; Lucas, H.; Sutter, P.; Larijani, M.
Catalytic pocket inaccessibility of activation-induced cytidine deaminase is a safeguard against excessive mutagenic activity (2015), Structure, 23, 615-627 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
generation of a panel of free or DNA-bound AID models based on eight recently resolved APOBEC isoform structures. The majority of AID:DNA complexes would be inactive due to substrate binding such that a cytidine is not positioned for deamination. Most AID conformations exhibit fully or partially occluded catalytic pockets	Homo sapiens
generation of a panel of free or DNA-bound AID models based on eight resolved APOBEC structures. The majority of AID:DNA complexes would be inactive due to substrate binding such that a cytidine is not positioned for deamination. Most AID conformations exhibit fully or partially occluded catalytic pockets	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Homo sapiens	P31941	-	-

Synonyms

Synonyms	Comment	Organism
activation-induced cytidine deaminase	-	Homo sapiens
AID	-	Homo sapiens
APOBEC3A	-	Homo sapiens

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Release 2023.1 (January 2023)