Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
anandamide + H2O | Rattus norvegicus | the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers | ethanolamine + arachidonic acid | - |
? | |
oleamide + H2O | Rattus norvegicus | the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers | oleic acid + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(11Z)-eicosenamide + H2O | 105% of the activity with oleamide | Rattus norvegicus | (11Z)-eicosenoic acid + NH3 | - |
? | |
(12Z)-octadecenamide + H2O | 92% of the activity with oleamide | Rattus norvegicus | (12Z)-octadecenoic acid + NH3 | - |
? | |
(13Z)-eicosenamide + H2O | 103% of the activity with oleamide | Rattus norvegicus | (13Z)-eicosenoic acid + NH3 | - |
? | |
(13Z)-octadecenamide + H2O | 82% of the activity with oleamide | Rattus norvegicus | (13Z)-octadecenoic acid + NH3 | - |
? | |
(15Z)-octadecenamide + H2O | 90% of the activity with oleamide | Rattus norvegicus | (15Z)-octadecenoic acid + NH3 | - |
? | |
(5Z)-eicosenamide + H2O | 116% of the activity with oleamide | Rattus norvegicus | (5Z)-eicosenoic acid + NH3 | - |
? | |
(6Z)-octadecenamide + H2O | 91% of the activity with oleamide | Rattus norvegicus | (6Z)-octadecenoic acid + NH3 | - |
? | |
(7Z)-octadecenamide + H2O | 109% of the activity with oleamide | Rattus norvegicus | (7Z)-octadecenoic acid + NH3 | - |
? | |
(8Z)-eicosenamide + H2O | 112% of the activity with oleamide | Rattus norvegicus | (8Z)-eicosenoic acid + NH3 | - |
? | |
(9E)-octadecenamide + H2O | 52% of the activity with oleamide | Rattus norvegicus | (9E)-octadecenoic acid + NH3 | - |
? | |
(9Z)-tetradec-9-enamide + H2O | 86% of the activity with oleamide | Rattus norvegicus | myristoleic acid + NH3 | - |
? | |
(9Z,12Z)-octadeca-9,12-dienamide + H2O | 104% of the activity with oleamide | Rattus norvegicus | (9Z,12Z)-octadeca-9,12-dienoate + NH3 | - |
? | |
11,14,17-eicosatrienamide + H2O | 140% of the activity with oleamide | Rattus norvegicus | 11,14,17-eicosatrienoic acid + NH3 | - |
? | |
11,14-eicosadienamide + H2O | 127% of the activity with oleamide | Rattus norvegicus | ? + NH3 | - |
? | |
2,2-dimethyloleamide + H2O | 3% of the activity with oleamide | Rattus norvegicus | 2,2-dimethyloleic acid + NH3 | - |
? | |
2-methyloleamide + H2O | 7% of the activity with oleamide | Rattus norvegicus | 2-methyloleic acid + NH3 | - |
? | |
8,11,14-eicosatrienamide + H2O | 138% of the activity with oleamide | Rattus norvegicus | 8,11,14-eicosatrienoic acid + NH3 | - |
? | |
alpha-linolenamide + H2O | 138% of the activity with oleamide | Rattus norvegicus | ? + NH3 | - |
? | |
anandamide + H2O | the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers | Rattus norvegicus | ethanolamine + arachidonic acid | - |
? | |
anandamide + H2O | 168% of the activity with oleamide | Rattus norvegicus | ethanolamine + arachidonic acid | - |
? | |
arachidonamide + H2O | 311% of the activity with oleamide | Rattus norvegicus | arachidonic acid + NH3 | - |
? | |
dodecanoamide + H2O | 74% of the activity with oleamide | Rattus norvegicus | dodecanoic acid + NH3 | - |
? | |
erucamide + H2O | 83% of the activity with oleamide | Rattus norvegicus | ? + NH3 | - |
? | |
linoelaidamide + H2O | 54% of the activity with oleamide | Rattus norvegicus | (9E,12E)-octadeca-9,12-dienoic acid + NH3 | - |
? | |
additional information | FAAH is an enzyme of broad substrate specificity and is capable of hydrolyzing a wide array of unsaturated, and to a lesser extent saturated, fatty acid primary amides. However, when substituted adjacent to the amide carbonyl, the substrates can be made sterically or electronically resistant to hydrolysis. Long chain saturated fatty acid amides are hydrolyzed slower than the corresponding Z unsaturated fatty acid amides and the rate of hydrolysis increases incrementally with increases in the degree of unsaturation | Rattus norvegicus | ? | - |
? | |
myristic amide + H2O | 83% of the activity with oleamide | Rattus norvegicus | myristic acid + NH3 | - |
? | |
nervonamide + H2O | 82% of the activity with oleamide | Rattus norvegicus | ? + NH3 | - |
? | |
oleamide + H2O | - |
Rattus norvegicus | oleic acid + NH3 | - |
? | |
oleamide + H2O | the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers | Rattus norvegicus | oleic acid + NH3 | - |
? | |
palmitoamide + H2O | 72% of the activity with oleamide | Rattus norvegicus | palmitic acid + NH3 | - |
? | |
palmitoleamide + H2O | 79% of the activity with oleamide | Rattus norvegicus | palmitoleic acid + NH3 | - |
? | |
stearamide + H2O | 69% of the activity with oleamide | Rattus norvegicus | stearic acid + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
anandamide amidohydrolase | - |
Rattus norvegicus |
FAAH | - |
Rattus norvegicus |
oleamide hydrolase | - |
Rattus norvegicus |