Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(11Z)-eicosenamide + H2O
(11Z)-eicosenoic acid + NH3
-
105% of the activity with oleamide
-
-
?
(12Z)-octadecenamide + H2O
(12Z)-octadecenoic acid + NH3
-
92% of the activity with oleamide
-
-
?
(13Z)-eicosenamide + H2O
(13Z)-eicosenoic acid + NH3
-
103% of the activity with oleamide
-
-
?
(13Z)-octadecenamide + H2O
(13Z)-octadecenoic acid + NH3
-
82% of the activity with oleamide
-
-
?
(15Z)-octadecenamide + H2O
(15Z)-octadecenoic acid + NH3
-
90% of the activity with oleamide
-
-
?
(5Z)-eicosenamide + H2O
(5Z)-eicosenoic acid + NH3
-
116% of the activity with oleamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-fluoroethyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolysis rate is 1.3fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-hydroxy-1,1-dimethylethyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 4.3% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-methylpropyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 2% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(3-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolysis rate is 1.5fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 16% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-tert-butylicosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 1.8% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-[(1S)-1-methylpropyl]icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 6.3% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-[(2R)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolysis rate is 1.2fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-[(2S)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 21% the rate of anandamide
-
-
?
(6Z)-octadecenamide + H2O
(6Z)-octadecenoic acid + NH3
-
91% of the activity with oleamide
-
-
?
(7Z)-octadecenamide + H2O
(7Z)-octadecenoic acid + NH3
-
109% of the activity with oleamide
-
-
?
(8Z)-eicosenamide + H2O
(8Z)-eicosenoic acid + NH3
-
112% of the activity with oleamide
-
-
?
(9E)-octadecenamide + H2O
(9E)-octadecenoic acid + NH3
-
52% of the activity with oleamide
-
-
?
(9Z)-N-(2-hydroxyethyl)octadec-9-enamide + H2O
?
-
hydrolyzed at 61% the rate of anandamide
-
-
?
(9Z)-N-ethyloctadec-9-enamide + H2O
oleic acid + ethanolamine
-
-
-
-
?
(9Z)-tetradec-9-enamide + H2O
myristoleic acid + NH3
-
86% of the activity with oleamide
-
-
?
(9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dienamide + H2O
?
-
hydrolyzed at 75% the rate of anandamide
-
-
?
(9Z,12Z)-N-[(1R)-2-hydroxy-1-methylethyl]octadeca-9,12-dienamide + H2O
?
-
hydrolyzed at 20.5% the rate of anandamide
-
-
?
(9Z,12Z)-octadeca-9,12-dienamide + H2O
(9Z,12Z)-octadeca-9,12-dienoate + NH3
-
104% of the activity with oleamide
-
-
?
(R)-alpha-methanandamide + H2O
?
-
2.4% of the activity with anandamide
-
-
?
(R)-beta-methanandamide + H2O
?
-
121% of the activity with anandamide
-
-
?
(S)-alpha-methanandamide + H2O
?
-
23% of the activity with anandamide
-
-
?
(S)-beta-methanandamide + H2O
?
-
21% of the activity with anandamide
-
-
?
1-arachidonoylglycerol + H2O
?
-
-
-
-
?
11,14,17-eicosatrienamide + H2O
11,14,17-eicosatrienoic acid + NH3
-
140% of the activity with oleamide
-
-
?
11,14-eicosadienamide + H2O
? + NH3
-
127% of the activity with oleamide
-
-
?
2,2-dimethyloleamide + H2O
2,2-dimethyloleic acid + NH3
-
3% of the activity with oleamide
-
-
?
2-arachidonoylglycerol + H2O
?
2-methyloleamide + H2O
2-methyloleic acid + NH3
-
7% of the activity with oleamide
-
-
?
2-oleoylglycerol + H2O
?
-
-
-
-
?
8,11,14-eicosatrienamide + H2O
8,11,14-eicosatrienoic acid + NH3
-
138% of the activity with oleamide
-
-
?
all-trans-anandamide + H2O
ethanolamine + arachidonic acid
-
all-trans-anandamide is an equally good substrate for rabbit platelet FAAH compared to anandamide
-
-
?
alpha-linolenamide + H2O
? + NH3
-
138% of the activity with oleamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
anandamide + H2O
ethanolamine + arachidonic acid
arachidonamide + H2O
arachidonic acid + NH3
arachidonoyl 7-amido-4-methylcoumarin + H2O
arachidonic acid + 7-amino-4-methylcoumarin
arachidonoyl ethanolamide + H2O
arachidonic acid + ethanolamine
arachidonoyl p-nitroanilide + H2O
arachidonate + p-nitroaniline
-
-
-
-
?
arachidonyl-7-amino-4-methylcoumarin amide + H2O
arachidonic acid + 7-amino-4-methylcoumarin
beta-arachidonoylglycerol + H2O
?
-
hydrolysis is 2.5fold higher than the rate of anandamide hydrolysis
-
-
?
decanoyl 7-amido-4-methylcoumarin + H2O
?
decanoyl p-nitroanilide + H2O
decanoate + p-nitroaniline
-
-
-
-
?
dodecanoamide + H2O
dodecanoic acid + NH3
-
74% of the activity with oleamide
-
-
?
erucamide + H2O
? + NH3
-
83% of the activity with oleamide
-
-
?
heptanoyl p-nitroanilide + H2O
heptanoate + p-nitroaniline
-
-
-
-
?
lauroyl p-nitroanilide + H2O
laurate + p-nitroaniline
-
-
-
-
?
linoelaidamide + H2O
(9E,12E)-octadeca-9,12-dienoic acid + NH3
-
54% of the activity with oleamide
-
-
?
myristic amide + H2O
myristic acid + NH3
myristoyl p-nitroanilide + H2O
myristate + p-nitroaniline
-
-
-
-
?
N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
4-(pyren-1-yl)butanamide + ethylene glycol
-
-
-
?
N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
4-pyren-1-ylbutanoic acid + ?
-
-
-
-
?
N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
?
-
-
-
-
?
N-(2-hydroxyethyl)linoleoylamide + H2O
?
-
-
-
-
?
N-(2-hydroxyethyl)octadecanamide + H2O
?
-
hydrolyzed at 15.0% the rate of anandamide
-
-
?
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide + H2O
4-amino-m-cresol + NH3
-
the rate of metabolism of VDM11 is about 15â20% of that for anandamide
-
-
?
N-(4-nitrophenyl)decanamide + H2O
?
-
-
-
-
?
N-(4-nitrophenyl)octanamide + H2O
?
-
-
-
-
?
N-(6-methoxypyridin-3-yl)decanamide + H2O
?
-
-
-
-
?
N-(6-methoxypyridin-3-yl)octanamide + H2O
?
-
-
-
-
?
N-(o-hydroxyphenyl)arachidonamide + H2O
?
-
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
N-oleoyltaurine + H2O
taurine + oleic acid
4% of the activity with anandamide
-
-
?
N-palmitoyl ethanolamine + H2O
palmitic acid + ethanolamine
-
-
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
nervonamide + H2O
? + NH3
-
82% of the activity with oleamide
-
-
?
nonanoyl p-nitroanilide + H2O
nonanoate + p-nitroaniline
-
-
-
-
?
octanoyl p-nitroanilide + H2O
octanoate + p-nitroaniline
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
oleoyl ethanolamide + H2O
oleic acid + ethanolamine
oleoyl methyl amide + H2O
?
-
-
-
-
?
oleoyl methyl ester + H2O
?
-
-
-
-
?
oleoyl methyl ester + H2O
oleic acid + methanol
-
-
-
-
?
oleoyl p-nitroanilide + H2O
?
-
-
-
-
?
oleoyl p-nitroanilide + H2O
oleate + p-nitroaniline
-
-
-
-
?
oleoylethanolamide + H2O
oleic acid + ethanolamine
palmitic amide + H2O
palmitic acid + NH3
palmitoamide + H2O
palmitic acid + NH3
-
72% of the activity with oleamide
-
-
?
palmitoleamide + H2O
palmitoleic acid + NH3
-
79% of the activity with oleamide
-
-
?
palmitoyl p-nitroanilide + H2O
palmitate + p-nitroaniline
-
-
-
-
?
palmitoylethanolamide + H2O
palmitic acid + ethanolamine
-
substrate of FAAH and FAAH-2, the latter shows lower activity than FAAH
-
-
?
stearamide + H2O
stearic acid + NH3
-
69% of the activity with oleamide
-
-
?
stearic amide + H2O
stearic acid + NH3
additional information
?
-
2-arachidonoylglycerol + H2O

?
-
FAAH is responsible for approximately one-half of the 2-arachidonoylglycerol hydrolysis occurring in BV-2 cell homogenate
-
-
?
2-arachidonoylglycerol + H2O
?
-
-
-
-
?
anandamide + H2O

arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide, LC-MS/MS analysis
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
substrate of FAAH and FAAH-2, the latter shows lower activity than FAAH
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. N-arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide, LC-MS/MS analysis
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. N-arachidonoylethanolamine
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O

ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
FAAH-1 plays a primary role in regulating endocannabinoid signaling
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
5% of the activity with oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
anandamide hydrolysis in BV-2 cells is entirely attributable to FAAH
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
the enzyme cleaves anandamide and regulates in vivo the magnitude and duration of the signaling induced by this lipid messenger
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
the enzyme is responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
168% of the activity with oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
arachidonamide + H2O

arachidonic acid + NH3
-
-
-
-
?
arachidonamide + H2O
arachidonic acid + NH3
-
311% of the activity with oleamide
-
-
?
arachidonoyl 7-amido-4-methylcoumarin + H2O

arachidonic acid + 7-amino-4-methylcoumarin
-
-
-
-
?
arachidonoyl 7-amido-4-methylcoumarin + H2O
arachidonic acid + 7-amino-4-methylcoumarin
-
-
-
-
?
arachidonoyl ethanolamide + H2O

arachidonic acid + ethanolamine
-
-
-
?
arachidonoyl ethanolamide + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
arachidonyl-7-amino-4-methylcoumarin amide + H2O

arachidonic acid + 7-amino-4-methylcoumarin
fluorogenic substrate
-
-
?
arachidonyl-7-amino-4-methylcoumarin amide + H2O
arachidonic acid + 7-amino-4-methylcoumarin
fluorogenic substrate
-
-
?
decanoyl 7-amido-4-methylcoumarin + H2O

?
-
-
-
-
?
decanoyl 7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
myristic amide + H2O

myristic acid + NH3
65% of the activity with anandamide
-
-
?
myristic amide + H2O
myristic acid + NH3
-
24.3% of the activity with oleamide
-
-
?
myristic amide + H2O
myristic acid + NH3
-
24% of the activity with anandamide
-
-
?
myristic amide + H2O
myristic acid + NH3
-
83% of the activity with oleamide
-
-
?
N-arachidonoylethanolamine + H2O

arachidonic acid + ethanolamine
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
?
N-oleoylethanolamine + H2O

oleic acid + ethanolamine
-
-
-
?
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
23% of the activity with oleamide
-
-
?
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
33% of the activity with anandamide
-
-
?
N-palmitoylethanolamine + H2O

palmitic acid + ethanolamine
-
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
12% of the activity with anandamide
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
2.3% of the activity with oleamide
-
-
?
oleamide + H2O

oleic acid + NH3
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
?
oleamide + H2O
oleic acid + NH3
57% of the activity with anandamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
role of FAAH in epithelial cells of the choroid plexus may be to control the concentration of oleamide in the cerebrospinal fluid. FAAH may exert an important regulatory role in shaping the duration and magnitude of the sleep-inducing effect of endogenously or exogenously derived oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
the enzyme is responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers
-
-
?
oleamide + H2O
oleic acid + NH3
-
serine residue 241 acts as the catalytic nucleophile of the enzyme. FAAH does not utilize a histidine base for the activation of its serine nucleophile
-
-
?
oleamide + H2O
oleic acid + NH3
i.e. cis-9-octadecenamide
-
-
?
oleoyl ethanolamide + H2O

oleic acid + ethanolamine
-
-
-
?
oleoyl ethanolamide + H2O
oleic acid + ethanolamine
-
-
-
-
?
oleoylethanolamide + H2O

oleic acid + ethanolamine
-
-
-
?
oleoylethanolamide + H2O
oleic acid + ethanolamine
-
-
-
?
palmitic amide + H2O

palmitic acid + NH3
33% of the activity with anandamide
-
-
?
palmitic amide + H2O
palmitic acid + NH3
-
10% of the activity with anandamide
-
-
?
palmitic amide + H2O
palmitic acid + NH3
-
9.9% of the activity with oleamide
-
-
?
stearic amide + H2O

stearic acid + NH3
5.8% of the activity with anandamide
-
-
?
stearic amide + H2O
stearic acid + NH3
-
5.8% of the activity with anandamide
-
-
?
stearic amide + H2O
stearic acid + NH3
-
5.8% of the activity with oleamide
-
-
?
additional information

?
-
-
the substrate specificity of fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton
-
-
?
additional information
?
-
no activity with N-oleoyltaurine
-
-
?
additional information
?
-
no activity with N-oleoyltaurine
-
-
?
additional information
?
-
-
no activity with N-oleoyltaurine
-
-
?
additional information
?
-
-
FAAH inactivates anandamide and other bioactive N-acylethanolamines
-
-
?
additional information
?
-
-
the substrate specificity of fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton
-
-
?
additional information
?
-
FAAH is the primary N-arachidonoylethanolamine-degrading enzyme, but it is also capable of hydrolyzing other bioactive N-acylethanolamines, such as N-palmitoylethanolamine, N-oleoylethanolamine and the sleep-inducing lipid oleamide
-
-
?
additional information
?
-
-
catalytic efficiency (kcat/Km) of FAAH for nonanoyl p-nitroanilide is approximately 50fold higher than for hexanoyl p-nitroanilide. NAI491 participates in hydrophobic binding interactions with medium-chain FAAH substrates. Use of p-nitroanilide substrates allows for the precise monitoring of enzymatic hydrolysis rates by following the increase in UV absorbance at 382 nm due to the release of p-nitroaniline. p-Nitroanilides are slower FAAH substrates than the corresponding primary amides, however, the binding affinities of these two classes of substrates are equivalent. Due to the slower rates of p-nitroanilide hydrolysis relative to the corresponding primary amides, it can be assumed that pNA substrates are hydrolyzed by FAAH in an acylation rate-limiting manner, allowing for the direct measurement of substrate binding constants through the determination of Km values
-
-
?
additional information
?
-
-
FAAH is an enzyme of broad substrate specificity and is capable of hydrolyzing a wide array of unsaturated, and to a lesser extent saturated, fatty acid primary amides. However, when substituted adjacent to the amide carbonyl, the substrates can be made sterically or electronically resistant to hydrolysis. Long chain saturated fatty acid amides are hydrolyzed slower than the corresponding Z unsaturated fatty acid amides and the rate of hydrolysis increases incrementally with increases in the degree of unsaturation
-
-
?
additional information
?
-
-
hybrid quantum mechanics/molecular mechanics (QM/MM) calculations reveal a new mechanism of nucleophile activation involving a LysâSerâSer catalytic triad. The proposed mechanism, shows that Lys142 and cis-Ser217 have a direct role in the activation of Ser241, in agreement with kinetic labelling experiments employing the highly reactive fluorophosphonatetetramethyl rhodamine. The greater reduction of Ser241 labelling rate in the K142A/S217A double mutant, compared to the K142A and S217A single mutants, suggests that Lys142 and Ser217 cooperate to deprotonate Ser241
-
-
?
additional information
?
-
-
N,N-bis(2-hydroxyethyl)arachidonamide is not hydrolyzed
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(1-benzhydryltriazol-4-yl)methyl N-cyclohexylcarbamate
73% inhibition at 0.1 mM
(1-benzothiophen-6-ylamino)([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)methanone
-
-
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
(1-benzyltriazol-4-yl)methyl N-cyclohexylcarbamate
-
(1-phenethyltriazol-4-yl)methyl N-cyclohexylcarbamate
-
(1-phenyltriazol-4-yl)methyl N-cyclohexylcarbamate
-
(10Z)-1,1,1-trifluorononadec-10-en-2-one
-
-
(10Z)-1-bromononadec-10-en-2-one
-
-
(10Z)-2-oxononadec-10-enamide
-
-
(1H-benzo[d][1,2,3]triazol-1-yl)(4-(3-phenoxybenzyl)-piperazin-1-yl)-methanone
-
(1H-benzo[d][1,2,3]triazol-1-yl)(4-(4-phenoxybenzyl)-piperazin-1-yl)-methanone hydrochloride
-
(1H-imidazol-1-yl)(4-(3-phenoxybenzyl)piperazin-1-yl)methanone
-
(1H-imidazol-1-yl)(4-(4-phenoxy-benzyl)-piperazin-1-yl)-methanone hydrochloride
-
(2R)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(2S)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(3-phenylphenyl)methyl N-cyclohexylcarbamate
65% inhibition at 0.1 mM
(3H-[1,2,3]triazol[4,5-b]pyridin-3-yl)(4-(3-phenoxybenzyl)-piperazin-1-yl)-methanone
-
(3R,4R)-4-acetoxy-3-((10R)-(t-butyldimethylsilyloxy)-ethyl)-azetidin-2-one
-
(4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)-piperidin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
-
(4-benzhydrylpiperazin-1-yl)(4-phenyl-1H-imidazol-1-yl)methanone
62% activity remaining at 0.01 mM
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
(4-phenylpiperazin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
-
(5-iodo-1,3-oxazol-2-yl)[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
(5-iodo-1,3-oxazol-2-yl)[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
(5E)-5-(4-methoxybenzylidene)-3-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1,3-thiazolidine-2,4-dione
-
-
(5Z,8Z,11Z,14Z)-1-pyridazin-3-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
-
-
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
-
i.e. (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide or N-arachidonoylethanolamine, competitive
(5Z,8Z,11Z,14Z)-N-[(2R)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
-
-
(5Z,8Z,11Z,14Z)-N-[(2S)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
-
-
(6aR,10aR)-3-(1,1-dimethylheptyl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
-
-
(6E,9E,12E,15E)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
-
(9E)-1-pyridazin-3-yloctadec-9-en-1-one
-
-
(9E)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-(1,3-benzothiazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1,3-oxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1,3-thiazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1-methyl-1H-benzimidazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1-methyl-1H-imidazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1-methyl-1H-tetrazol-5-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1H-benzimidazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1H-tetrazol-5-yl)octadec-9-en-1-one
-
-
(9Z)-1-(2-methyl-2H-tetrazol-5-yl)octadec-9-en-1-one
-
-
(9Z)-1-(4,5-dihydro-1,3-oxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(4-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(5-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(6-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(7-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-phenyloctadec-9-en-1-one
-
-
(9Z)-1-pyrazin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-pyridazin-3-yloctadec-9-en-1-one
-
-
(9Z)-1-pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-pyrimidin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-pyrimidin-4-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[5,4-b]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-yloctadec-9-en-1-one
-
-
(benzyl-1,2,4-triazol-3-yl)methyl N-cyclohexylcarbamate
-
(dodecylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
(phenylamino)[[(4-phenylcyclohexylidene)amino]oxy]methanone
-
-
(phenylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
(phenylamino)[[(E)-[1-[4-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl 2-(biphenyl-4-yl)acetate
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl 3-(1H-indol-3-yl)propanoate
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl biphenyl-4-carboxylate
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl-4-phenylbutanoate
-
([(E)-[1-(2,2'-bithiophen-5-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(4-cyclohexylphenyl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(diphenylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(phenylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(piperidin-1-yl)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-fluorophenyl)amino]methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-methoxyphenyl)amino]methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(5-phenylpentyl)amino]methanone
-
-
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(dimethylamino)methanone
-
-
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(phenylamino)methanone
-
-
1,1'-(5,5'-bi-1,3-oxazole-2,2'-diyl)bis(7-phenylheptan-1-one)
-
-
1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
-
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
1,1-biphenyl-3-yl-carbamic acid cyclohexyl ester
-
i.e. URB602
1,2,3,4-tetrahydronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
59.6% inhibition at 0.01 mM
1,3-benzodioxol-5-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
1,3-oxazol-2-yl[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]methanone
-
1,3-oxazol-2-yl[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]methanone
-
1,3-oxazol-2-yl[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
1,3-oxazol-2-yl[(3R)-7-phenyl-3,4-dihydro-2H-chromen-3-yl]methanone
-
1,3-oxazol-2-yl[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
1,3-oxazol-2-yl[(3S)-7-phenyl-3,4-dihydro-2H-chromen-3-yl]methanone
-
1-(1,3-benzoxazol-2-yl)octadecan-1-one
-
-
1-(1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(1-phenyl-1,2,4-triazol-3-yl)methyl N-cyclohexylcarbamate
70% inhibition at 0.1 mM
1-(1H-benzimidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
1-(1H-benzotriazol-1-yl)-3-[(3'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(3'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(4'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]butan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(4-phenoxyphenyl)thio]propan-2-one
-
1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]pentan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-imidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-imidazo[4,5-b]pyridin-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-indazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-indazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
-
-
1-(2-oxo-3-[4-[4-(trifluoromethyl)phenoxy]phenoxy]propyl)-1H-indole-5-carboxylic acid
-
21% inhibition at 0.01 mM
1-(2-oxo-3-[[4'-(propan-2-yl)biphenyl-4-yl]oxy]propyl)-1H-indole-5-carboxylic acid
-
-
1-(3H-imidazo[4,5-b]pyridin-3-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(4-benzylpiperazin-1-yl)-2-[4-(2-methylpropyl)phenyl]propan-1-one
18% inhibition at 0.1 mM
1-(4-octylphenoxy)-3-(1H-1,2,4-triazol-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-pyrazol-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-pyrazolo[3,4-b]pyridin-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-pyrazolo[4,3-b]pyridin-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-tetrazol-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-[1,2,3]triazolo[4,5-b]pyridin-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(2H-1,2,3-triazol-2-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-[5-(1H-tetrazol-5-yl)-1H-indol-1-yl]propan-2-one
-
-
1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one
-
-
1-(5-acetyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-bromo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-chloro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-fluoro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-furan-2-yl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-iodo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-methyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-nitro-1H-indazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
-
-
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
1-benzothiophen-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one
-
-
1-pyridazin-3-yloctadecan-1-one
-
-
1-[(3R)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
-
-
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl (benzyloxy)acetate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 3-(1H-indol-3-yl)propanoate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 4-(pyridin-2-yl)butanoate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 4-(pyridin-4-yl)butanoate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl biphenyl-4-carboxylate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl biphenyl-4-ylacetate
-
1-[([1,1'-biphenyl]-4-yl)oxy]-3-(1H-tetrazol-1-yl)propan-2-one
-
-
1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)butan-2-one
-
-
1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)propan-2-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-4-phenylbutan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-5-phenylpentan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-6-phenylhexan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-7-phenylheptan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-8-phenyloctan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-9-phenylnonan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-en-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-yn-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldodecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylethanone
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylheptan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexadecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-yn-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylpentan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yltetradecan-1-one
-
-
1-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1H-benzimidazole-7-carboxylic acid
-
-
1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazole-5-carboxylic acid
-
-
1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
-
-
1-[2-oxo-3-[4-(2-phenoxyethoxy)phenoxy]propyl]-1H-indole-5-carboxylic acid
-
-
1-[2-oxo-3-[4-(2-phenylpropan-2-yl)phenoxy]propyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-benzylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indazole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid
1-[3-(biphenyl-2-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(biphenyl-3-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(biphenyl-4-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
39% inhibition at 0.01 mM
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
1-[3-[(4'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(4-fluorophenyl)phenoxy]-2-oxopropyl]indazole-5-carboxylic acid
-
-
1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(heptyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(hexyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(nonyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(octyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(2-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
33% inhibition at 0.1 mM
1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(3-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
41% inhibition at 0.1 mM
1-[4-(3-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(4-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(4-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-[(3-chlorophenyl)methyl]piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
8% inhibition at 0.1 mM
1-[4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidin-1-yl]-3,3,3-trifluoro-2-(trifluoromethyl)propan-1-one
-
1-[5-(2,4-dimethoxypyrimidin-5-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2,6-dimethoxypyrimidin-4-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-benzyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-(3-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-aminopyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-fluoropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methoxypyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-nitropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(5-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(6-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(methylsulfanyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(morpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(morpholin-4-ylcarbonyl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-[(4-methylpiperazin-1-yl)carbonyl]-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1H-benzimidazol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
1H-benzotriazol-1-yl[4-(diphenylmethyl)piperazin-1-yl]methanone
-
1H-indol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
2,2,2-trichloroethyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate
-
2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2,3-dihydro-1,4-benzodioxin-5-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
2-(1-benzyltriazol-4-yl)ethyl N-cyclohexylcarbamate
-
2-(1-phenyltriazol-4-yl)ethyl N-cyclohexylcarbamate
-
2-(1H-benzotriazol-1-yl)-1-(5-phenoxy-1,3-benzoxazol-2-yl)ethan-1-one
-
-
2-(2-fluorobiphenyl-4-yl)-N-(2-(3-methylpyridin-2-ylamino)-2-oxoethyl)propanamide
-
2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide
mode of inhibition, overview. Flu-AM1 does not inhibit the enzyme from brain in vivo
2-(4-cyclohexylphenoxy)-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[4-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2-(6-methoxynaphthalen-2-yl)-N-(3-methylpyridin-2-yl)propanamide
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carbaldehyde
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carbonitrile
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylic acid
-
-
2-(methylamino)-2-oxoethyl [2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate
2-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
2-hydroxy-N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]acetamide
-
-
2-iodobenzylarachidonoylamide
-
-
2-iodobenzyllinoleoylamide
-
-
2-iodophenethylarachidonoylamide
-
-
2-iodophenethyllinoleoylamide
-
-
2-methoxy-N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]acetamide
-
-
2-methoxyphenethylarachidonoylamide
-
-
2-methoxyphenethyllinoleoylamide
-
-
2-methyl-N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylic acid
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carbonitrile
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylic acid
-
-
2-[4-(2-methylpropyl)phenyl]-1-(4-phenylpiperazin-1-yl)propan-1-one
-
2-[4-(2-methylpropyl)phenyl]-N-(3-methylpyridin-2-yl)propanamide
-
2-[4-(2-methylpropyl)phenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]propanamide
-
2-[4-(2-methylpropyl)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2H-benzotriazol-2-yl(4-phenylpiperazin-1-yl)methanone
-
2H-benzotriazol-2-yl[4-(diphenylmethyl)piperazin-1-yl]methanone
-
3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate
-
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
-
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide
-
-
3-(1H-benzotriazol-1-yl)-1-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
-
-
3-iodobenzylarachidonoylamide
-
-
3-iodobenzyllinoleoylamide
-
-
3-iodophenethylarachidonoylamide
-
-
3-iodophenethyllinoleoylamide
-
-
3-methoxyphenethylarachidonoylamide
-
-
3-methoxyphenethyllinoleoylamide
-
-
3-phenylpropane-1-sulfonyl fluoride
-
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
3-[([1,1'-biphenyl]-4-yl)oxy]-1-(1H-tetrazol-1-yl)butan-2-one
-
-
3-[([1,1'-biphenyl]-4-yl)oxy]-1-(2H-tetrazol-2-yl)butan-2-one
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
4-(3-phenoxybenzyl)-N-(4-methoxyphenyl)piperazine-1-carboxamide
-
4-(3-phenoxybenzyl)-N-(4-nitrophenyl)piperazine-1-carboxamide
-
4-(3-phenoxybenzyl)-N-phenylpiperazine-1-carboxamide
-
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
4-(4-benzyloxyphenoxy)butanesulfonyl fluoride
-
4-(acetylamino)phenyl (4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetate
-
-
4-(acetylamino)phenyl 2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
-
competitive, also able to inhibit the FAAH activity in rat basophilic leukemia cells as assessed by measuring either the hydrolysis of anandamide, the FAAH-dependent cellular accumulation of anandamide, or the FAAH-dependent recycling of tritium to the cellmembranes
4-(acetylamino)phenyl 2-[[2-(trifluoromethyl)pyridin-4-yl]amino]pyridine-3-carboxylate
-
-
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate
-
-
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylate
-
-
4-(acetylamino)phenyl 2-{[2-(trifluoromethyl)pyridin-4-yl]amino}benzoate
-
-
4-(acetylamino)phenyl 3-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
-
-
4-(acetylamino)phenyl 3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 3-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 4-([[2-(trifluoromethyl)pyridin-4-yl]amino]methyl)benzoate
-
-
4-(acetylamino)phenyl 4-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 5-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 5-methyl-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl N-(3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
-
-
4-(acetylamino)phenyl N-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
-
-
4-(acetylamino)phenyl N-[(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetyl]glycinate
-
-
4-(acetylamino)phenyl N-[2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoyl]glycinate
-
-
4-(benzyloxy)phenyl butylcarbamate
-
4-benzhydryl-N-(4-(trifluoromethyl)phenyl)piperazine-1-carboxamide
86% activity remaining at 0.01 mM
4-benzhydryl-N-(4-butylphenyl)piperazine-1-carboxamide
84% activity remaining at 0.01 mM
4-benzhydryl-N-(4-methoxyphenyl)piperazine-1-carboxamide
89% activity remaining at 0.01 mM
4-benzhydryl-N-(4-nitrophenyl)piperazine-1-carboxamide
84% activity remaining at 0.01 mM
4-benzhydryl-N-(pyridin-2-yl)piperazine-1-carboxamide
87% activity remaining at 0.01 mM
4-benzhydryl-N-(pyridin-3-yl)piperazine-1-carboxamide
87% activity remaining at 0.01 mM
4-benzhydryl-N-phenylpiperazine-1-carboxamide
88% activity remaining at 0.01 mM
4-carbamoylnaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
4-fluoronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
4-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
4-hydroxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
4-iodobenzylarachidonoylamide
-
-
4-iodobenzyllinoleoylamide
-
-
4-iodophenethylarachidonoylamide
-
-
4-iodophenethyllinoleoylamide
-
-
4-methoxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
4-methoxyphenethylarachidonoylamide
-
-
4-methoxyphenethyllinoleoylamide
-
-
4-methoxyphenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
-
4-nitrophenyl 4-(diphenylmethyl)piperazine-1-carboxylate
-
4-nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate
-
4-nitrophenyl 4-[bis(4-fluorophenyl)methyl]piperazine-1-carboxylate
-
4-nitrophenyl-4-(4-phenoxy-benzyl)-piperazine-1-carboxylate
-
4-nitrophenyl-4-(bis(benzo[d][1,3]dioxol-5-yl)methyl)piperidine-1-carboxylate
-
4-phenylbutane-1-sulfonyl fluoride
-
4-[([4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamoyl)oxy]naphthalene-1-carboxylic acid
-
-
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
4-[3-(4-chlorophenoxy)benzyl]-N-(pyridin-3-yl)piperazine-1-carboxamide
4-[3-[4-(decyloxy)phenoxy]-2-oxopropoxy]benzoic acid
-
-
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
5,6,7,8-tetrahydronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
5-(4-benzyloxyphenyl)pentanesulfonyl fluoride
-
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-morpholin-4-yl-1H-pyrazole-3-carboxamide
-
-
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
5-phenylpentane-1-sulfonyl fluoride
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylic acid
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylic acid
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-sulfonamide
-
-
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
6-hydroxybiphenyl-3-yl cyclohexylcarbamate
6-phenylhexane-1-sulfonyl fluoride
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxamide
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione
-
-
7-(2-benzyloxyphenyl)heptanesulfonyl fluoride
-
7-(2-hydroxyphenyl)heptanesulfonyl fluoride
-
7-(3-benzyloxyphenyl)heptanesulfonyl fluoride
-
7-(3-hydroxyphenyl)heptanesulfonyl fluoride
-
7-(4-benzyloxyphenyl)heptane-1-sulfonic acid methyl ester
-
7-(4-benzyloxyphenyl)heptanesulfonyl fluoride
-
7-(4-hydroxyphenyl)heptanesulfonyl fluoride
-
7-phenyl-1-(5-phenyl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
7-phenyl-1-(5-pyrimidin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyrimidin-4-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyrimidin-5-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-thiophen-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-[5-(1H-tetrazol-5-yl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(piperidin-1-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
7-phenyl-1-[5-(thiomorpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(trifluoroacetyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[2-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[3-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[4-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[4-(trifluoromethyl)pyridin-2-yl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenylheptane-1-sulfonyl fluoride
-
8-phenyloctane-1-sulfonyl fluoride
-
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
benzyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)-piperidine-1-carboxylate
-
biphenyl-3-yl cyclohexylcarbamate
cis-anandamide
-
inhibits hydrolysis of anandamide
cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester
-
i.e. URB597, attenuates the development of lipopolysaccharide-induced paw edema and reverses lipopolysaccharide-induced hyperalgesia through the respective CB2 and CB1 mechanisms of action. The inhibition is not affected by capsazepine, a transient receptor potential vanilloid type 1 antagonist
decyl benzodioxaphosphorin oxide
-
-
diisopropyl fluorophosphate
-
-
dodecyl benzodioxaphosphorin oxide
-
-
dodecyl sulfonyl fluoride
-
-
dodecyl-benzodioxaphosphorin oxide
-
-
ethoxy oleoyl fluorophosphonate
-
irreversible inhibitor, exclusively modifies FAAH at S241
ethyl (10Z)-2-oxononadec-10-enoate
-
-
ethyl 4-(1H-1,2,4-triazol-1-ylcarbonyl)piperazine-1-carboxylate
-
ethyl 4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-ylcarbonyl)piperazine-1-carboxylate
-
ethyl octylphosphonofluoridate
-
-
heptyl benzodioxaphosphorin oxide
-
-
hexadecyl sulfonylfluoride
isopropyl dodecylfluorophosphate
-
-
methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate
-
-
methyl 2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylate
-
-
methyl 3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylate
-
-
methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylate
-
-
methyl 6-(2-[[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-(2-[[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-(2-[[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-(2-[[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl arachidonoyl fluorophosphonate
methyl arachidonyl fluorophosphonate
methyl arachidonyl phosphonofluoridate
-
-
methyl arachidonylfluoroposphate
-
-
methyl octylphosphonofluoridate
-
-
methyl [1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamate
-
-
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
N,N-dimethyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N-(1,4-dihydroquinolin-8-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(2-hydroxyethyl)linoleoylamide
-
competitive versus anadamide
N-(2-methylphenyl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
N-(3-bromopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-chloropyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-iodopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclobutane-1-carboxamide
-
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclohexane-1-carboxamide
30% inhibition at 0.1 mM
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopentane-1-carboxamide
-
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopropane-1-carboxamide
-
N-(3-methylpyridin-2-yl)-2-(4'-isobutylphenyl)propionamide
-
i.e. Ibu-am5
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[8-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
-
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide
-
i.e. VDM11, inhibits the metabolism of anandamide by rat brain FAAH. Inhibition may at least in part be a consequence of the compound acting as an alternative substrate
N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
-
i.e. AM404, a bioactive N-acylphenolamine, derived from paracetamol, competitve inhibition
N-(4-hydroxyphenyl)arachidonylamide
-
i.e. AM404, inhibits the metabolism of anandamide by rat brain FAAH
N-(4-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(5-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(phenylcarbamoyl)-3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide
-
-
N-(pyrazin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyridazin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzylidene)piperidine-1-carboxamide
N-(pyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyridin-3-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyridin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzyl)piperidine-1-carboxamide
-
N-(pyridin-4-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyrimidin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
N-cyclohexyl-N'-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]urea
-
-
N-ethyl-N'-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]urea
-
-
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
N-methyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N-n-heptyl benzodioxaphosphorin oxide
-
-
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
N-phenyl-4-(3-phenyl-4,5-dihydro-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
N-[(2,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(2,5-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(2,6-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
19% inhibition at 0.1 mM
N-[(2-chlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(2-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(3,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(3-hydroxy-4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(pyridin-2-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[(pyridin-3-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]acetamide
-
-
N-[2-[(3-methylpyridin-2-yl)amino]-2-oxoethyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[3-(trifluoromethyl)pyridin-2-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-phenoxyacetamide
-
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-[4-(propan-2-yl)phenoxy]acetamide
-
N-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
24% inhibition at 0.1 mM
N-[4-(2-methylphenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
24% inhibition at 0.1 mM
N-[4-(4-chlorophenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
naphthalen-1-yl (3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propyl)carbamate
-
-
naphthalen-1-yl (4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]butyl)carbamate
-
-
naphthalen-1-yl [3-[4-(2,3-dichlorophenyl)piperazin-1-yl]propyl]carbamate
-
-
naphthalen-1-yl [3-[4-(3-methoxyphenyl)piperazin-1-yl]propyl]carbamate
-
-
naphthalen-1-yl [3-[4-(3-methylphenyl)piperazin-1-yl]propyl]carbamate
-
-
naphthalen-1-yl [4-[4-(3-methoxyphenyl)piperazin-1-yl]butyl]carbamate
-
-
naphthalen-1-yl [4-[4-(3-methylphenyl)piperazin-1-yl]butyl]carbamate
-
-
naproxen
38% inhibition at 0.1 mM
O-n-octyl benzodioxaphosphorin oxide
-
-
O-octyl-benzodioxaphosphorin oxide
-
-
octyl sulfonyl fluoride
-
-
octyl-benzodioxaphosphorin oxide
-
-
oleyl-benzodioxaphosphorin oxide
-
-
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
oxiran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
oxiran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
oxiran-2-ylmethyl benzoate
-
-
PF-04457845
potently inhibits the enzyme regardless the route selected
phenyl ([4-[(5-phenyl-2H-tetrazol-2-yl)methyl]phenyl]methyl)carbamate
-
phenyl 4-[(1H-indol-1-yl)methyl]piperidine-1-carboxylate
-
phenyl 4-[2-(1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(4-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-chloro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-cyano-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-methoxy-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-methyl-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperazine-1-carboxylate
-
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(7-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(9H-carbazol-9-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[3-(1H-indol-1-yl)propyl]piperidine-1-carboxylate
-
phenyl 4-[4-(1H-indol-1-yl)butyl]piperidine-1-carboxylate
-
phenyl [1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamate
-
-
phenyl [2-[2-(5-phenyl-2H-tetrazol-2-yl)ethoxy]ethyl]carbamate
-
phenyl [4-(1H-indol-1-yl)butyl]carbamate
-
phenyl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
phenyl [5-(1H-indol-1-yl)pentyl]carbamate
-
phenyl [5-(2-phenyl-1H-imidazol-1-yl)pentyl]carbamate
-
phenyl [5-(5-phenyl-2H-tetrazol-2-yl)pentyl]carbamate
-
phenyl [6-(1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(1H-indol-1-yl)hexyl]carbamate
-
phenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(2-phenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(4-phenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(5-benzyl-2H-tetrazol-2-yl)hexyl]carbamate
-
phenyl [6-(5-phenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(5-phenyl-1H-tetrazol-1-yl)hexyl]carbamate
-
phenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
phenyl [6-[2-(3-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(3-fluorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(3-methoxyphenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(3-methylphenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(4-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[5-(2-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(3-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(4-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(pyridin-2-yl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(pyridin-3-yl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(pyridin-4-yl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [7-(1H-indol-1-yl)heptyl]carbamate
-
phenyl [7-(2-phenyl-1H-imidazol-1-yl)heptyl]carbamate
-
phenyl [7-(5-phenyl-2H-tetrazol-2-yl)heptyl]carbamate
-
phenyl [8-(1H-indol-1-yl)octyl]carbamate
-
phenyl [8-(2-phenyl-1H-imidazol-1-yl)octyl]carbamate
-
phenyl [8-(5-phenyl-2H-tetrazol-2-yl)octyl]carbamate
-
phenyl-benzodioxaphosphorin oxide
-
-
phenylmethane sulfonyl fluoride
irreversible inhibition
piperidin-1-yl[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
pyridin-3-yl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
S-heptyl benzodioxaphosphorin oxide
-
-
S-nonyl benzodioxaphosphorin oxide
-
-
S-pentyl benzodioxaphosphorin oxide
-
-
stearyl benzodioxaphosphorin oxide
-
-
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl benzoate
-
-
tetrahydro-2H-pyran-4-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
trans-anandamide
-
inhibits hydrolysis of anandamide
[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl (benzyloxy)acetate
-
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl 4-(pyridin-2-yl)butanoate
-
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl 4-(pyridin-4-yl)butanoate
-
[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3R)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl](1,3-oxazol-2-yl)methanone
-
[(3R)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3R)-7-phenyl-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3S)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl](1,3-oxazol-2-yl)methanone
-
[(3S)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3S)-7-phenyl-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
[1-(2-naphthylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]cyanamide
-
-
-
[1-(m-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-(o-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-(p-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-fluoro-3-methoxy-phenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(4-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(4-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[4-(3-phenoxybenzyl)piperazin-1-yl](1H-1,2,4-triazol-1-yl)methanone
-
[4-(diphenylmethyl)piperazin-1-yl](1H-1,2,4-triazol-1-yl)methanone
-
[4-(diphenylmethyl)piperazin-1-yl](1H-imidazol-1-yl)methanone
-
[4-[bis(1,3-benzodioxol-5-yl)methyl]piperidin-1-yl](1H-1,2,4-triazol-1-yl)methanone
-
[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl](1H-1,2,4-triazol-1-yl)methanone
-
[[(E)-[1-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]ethylidene]amino]oxy](naphthalen-1-ylamino)methanone
-
-
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone

-
-
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone

-
-
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide

-
-
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
-
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one

-
-
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
-
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one

-
-
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
-
-
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one

the compound belongs to the ketobenzimidazoles, though containing a carbonyl moiety, that do not covalently modify Ser241. These inhibitors achieve potent inhibition of FAAH activity primarily from shape complementarity to the active site and through numerous hydrophobic interactions exhibiting excellent selectivity and good pharmacokinetic properties, nonmechanism-based inhibition
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
the compound belongs to the ketobenzimidazoles, though containing a carbonyl moiety, that do not covalently modify Ser241. These inhibitors achieve potent inhibition of FAAH activity primarily from shape complementarity to the active site and through numerous hydrophobic interactions exhibiting excellent selectivity and good pharmacokinetic properties, nonmechanism-based inhibition. Pharmacokinetic parameters and selectivity 2, overview
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid

-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid
-
structure-activity relationship, overview
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid

-
-
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
2-(methylamino)-2-oxoethyl [2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate

-
2-(methylamino)-2-oxoethyl [2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate

-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
exerts a combination of anxiolytic-like, anti-depressant-like, and analgesic effects, due to its ability to inhibit FAAH activity in the CNS and peripheral tissues. Covalent enzyme binding at Ser241 leading to irreversible inhibition, the attack at the carbonyl group by Ser 241 leads to the formation of carbamoylated, catalytically inactive FAAH and releasing the O-biphenyl moiety as the leaving group
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
irreversible inhibitor
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
-
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
covalent enzyme binding at Ser241 leading to irreversible inhibition, the attack at the carbonyl group by Ser 241 leads to the formation of carbamoylated, catalytically inactive FAAH and releasing the O-biphenyl moiety as the leaving group
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate

-
-
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
-
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate

i.e. ASP8477; i.e. ASP8477
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
i.e. ASP8477
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide

-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide

-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide

-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide

-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
-
-
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide

-
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
-
JNJ-1661010
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[3-(4-chlorophenoxy)benzyl]-N-(pyridin-3-yl)piperazine-1-carboxamide

-
4-[3-(4-chlorophenoxy)benzyl]-N-(pyridin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide

-
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

analgesic effect of 21d in rat inflammatory pain model, overview
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

-
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
5-(4-hydroxyphenyl)pentanesulfonyl fluoride

i.e. AM3506, irreversible inhibitor for both the rat and the human enzyme, that covalently modifies the enzyme
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
i.e. AM3506, irreversible inhibitor for both the rat and the human enzyme
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide

an irreversible covalent inhibitor, binding structure, overview
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
an irreversible covalent inhibitor, binding structure, overview
6-hydroxybiphenyl-3-yl cyclohexylcarbamate

-
6-hydroxybiphenyl-3-yl cyclohexylcarbamate
-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one

-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one

-
OL-135, an alpha-keto-heterocycle that is a covalent reversible inhibitor of FAAH
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
reversible inhibitor
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
-
OL-135, an alpha-keto-heterocycle that is a covalent reversible inhibitor of FAAH
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
i.e. OL-135, the enzyme inhibitor exhibits antinociceptive and anti-inflammatory activity and increases levels of anandamide in vivo
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone

-
-
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone

-
-
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
biphenyl-3-yl cyclohexylcarbamate

-
biphenyl-3-yl cyclohexylcarbamate
-
CF3-OH

-
hexadecyl sulfonylfluoride

i.e. AM374, is a potent irreversible in vitro and in vivo inhibitor of fatty acid amide hydrolase
hexadecyl sulfonylfluoride
i.e. AM374, is a potent in vitro and in vivo inhibitor of fatty acid amide hydrolase
methyl arachidonoyl fluorophosphonate

-
methyl arachidonoyl fluorophosphonate
-
methyl arachidonyl fluorophosphonate

-
-
methyl arachidonyl fluorophosphonate
-
MAFP, a potent irreversible FAAH inhibitor
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide

-
-
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

-
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-(pyridazin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzylidene)piperidine-1-carboxamide

-
N-(pyridazin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzylidene)piperidine-1-carboxamide
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide

-
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide

-
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide

-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide

-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide

-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide

-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide

-
-
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide

-
-
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

-
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide

-
-
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea

-
-
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
-
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide

-
a reversible, albeit slowly dissociating inhibitor of FAAH, reversibly and noncovalently inhibiting, molecular docking and computational modeling of interactions of the benzothiazole analogue 1 with humanized rat FAAH by induced fit docking, overview. Failure to observe the formation of covalent enzyme-inhibitor adduct or putative cleavage product using electrospray mass spectrometric techniques
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
-
a reversible, albeit slowly dissociating inhibitor of FAAH, reversibly and noncovalently inhibiting, molecular docking and computational modeling of interactions of the benzothiazole analogue 1 with humanized rat FAAH by induced fit docking, overview. Failure to observe the formation of covalent enzyme-inhibitor adduct or putative cleavage product using electrospray mass spectrometric techniques
OL-135

-
OL-135
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
OL-135
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
oleoyl ethylamide

-
FAAH inhibitor
oleoyl ethylamide
-
FAAH inhibitor
oleoyl ethylamide
-
FAAH inhibitor
oleoyl oxazolopyridine

-
i.e. oloxa, a potent noncompetitive inhibitor, almost complete inhibition at 50 nM
oleoyl oxazolopyridine
-
, i.e. oloxa, a potent noncompetitive inhibitor, almost complete inhibition at 50 nM
palmitoyl ethanolamide

-
a non-CB1 non-CB2 cannabinoid-like compound
palmitoyl ethanolamide
-
a non-CB1 non-CB2 cannabinoid-like compound
palmitoyl ethanolamide
-
a non-CB1 non-CB2 cannabinoid-like compound
PF-3845

-
FAAH inhibitor, in vivo inhibition
PF-3845
crystal structure analysis of enzyme-inhibitor complex. The inhibitor interacts with the catalytic triad and oxyanion hole residues
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate

-
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
-
URB597

-
URB597
-
a carbamate inhibiting FAAH covalently and irreversibly, time-dependent inhibition, overview
URB597
less effective inhibitor in the brain after oral administration while it reaches similar effects by intranasal (i.n.) and intraperitoneal routes. Intranasal URB597 delivery always increased N-acyl-ethanolamine levels in brain areas, whereas a parallel increase is not observed in the liver. By showing the efficacy of intranasal FAAH inhibition, evidence is provided that nose-to-brain delivery is a suitable alternative to enhance brain endocannabinoid tone for the treatment of neurodegenerative disorders and improve compliance of the patients
URB597
-
a carbamate inhibiting FAAH covalently and irreversibly, time-dependent inhibition, overview
URB597
a carbamate inhibitor that displays excellent selectivity for FAAH in the nervous system, although the inhibitor does inactivate additional peripheral hydrolases, enzyme-inhibitor binding structure, overview. The inhibitor interacts with the catalytic triad and oxyanion hole residues
VER-156084

-
a tetrasubstituted azetidine urea FAAH inhibitor
VER-156084
-
a tetrasubstituted azetidine urea FAAH inhibitor
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate

-
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate

-
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate

-
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate

-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate

-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate

-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate

-
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate

-
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate

-
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate

-
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate

-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate

-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate

-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate

-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone

-
-
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone

-
-
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone

-
-
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone

-
-
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone

-
-
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone

-
-
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone

-
-
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone

-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
-
-