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(11Z)-eicosenamide + H2O
(11Z)-eicosenoic acid + NH3
-
105% of the activity with oleamide
-
-
?
(12Z)-octadecenamide + H2O
(12Z)-octadecenoic acid + NH3
-
92% of the activity with oleamide
-
-
?
(13Z)-eicosenamide + H2O
(13Z)-eicosenoic acid + NH3
-
103% of the activity with oleamide
-
-
?
(13Z)-octadecenamide + H2O
(13Z)-octadecenoic acid + NH3
-
82% of the activity with oleamide
-
-
?
(15Z)-octadecenamide + H2O
(15Z)-octadecenoic acid + NH3
-
90% of the activity with oleamide
-
-
?
(5Z)-eicosenamide + H2O
(5Z)-eicosenoic acid + NH3
-
116% of the activity with oleamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-fluoroethyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolysis rate is 1.3fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-hydroxy-1,1-dimethylethyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 4.3% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-methylpropyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 2% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(3-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolysis rate is 1.5fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 16% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-tert-butylicosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 1.8% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-[(1S)-1-methylpropyl]icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 6.3% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-[(2R)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolysis rate is 1.2fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-[(2S)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 21% the rate of anandamide
-
-
?
(6Z)-octadecenamide + H2O
(6Z)-octadecenoic acid + NH3
-
91% of the activity with oleamide
-
-
?
(7Z)-octadecenamide + H2O
(7Z)-octadecenoic acid + NH3
-
109% of the activity with oleamide
-
-
?
(8Z)-eicosenamide + H2O
(8Z)-eicosenoic acid + NH3
-
112% of the activity with oleamide
-
-
?
(9E)-octadecenamide + H2O
(9E)-octadecenoic acid + NH3
-
52% of the activity with oleamide
-
-
?
(9Z)-N-(2-hydroxyethyl)octadec-9-enamide + H2O
?
-
hydrolyzed at 61% the rate of anandamide
-
-
?
(9Z)-N-ethyloctadec-9-enamide + H2O
oleic acid + ethanolamine
-
-
-
-
?
(9Z)-tetradec-9-enamide + H2O
myristoleic acid + NH3
-
86% of the activity with oleamide
-
-
?
(9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dienamide + H2O
?
-
hydrolyzed at 75% the rate of anandamide
-
-
?
(9Z,12Z)-N-[(1R)-2-hydroxy-1-methylethyl]octadeca-9,12-dienamide + H2O
?
-
hydrolyzed at 20.5% the rate of anandamide
-
-
?
(9Z,12Z)-octadeca-9,12-dienamide + H2O
(9Z,12Z)-octadeca-9,12-dienoate + NH3
-
104% of the activity with oleamide
-
-
?
(R)-alpha-methanandamide + H2O
?
-
2.4% of the activity with anandamide
-
-
?
(R)-beta-methanandamide + H2O
?
-
121% of the activity with anandamide
-
-
?
(S)-alpha-methanandamide + H2O
?
-
23% of the activity with anandamide
-
-
?
(S)-beta-methanandamide + H2O
?
-
21% of the activity with anandamide
-
-
?
1-arachidonoylglycerol + H2O
?
-
-
-
-
?
11,14,17-eicosatrienamide + H2O
11,14,17-eicosatrienoic acid + NH3
-
140% of the activity with oleamide
-
-
?
11,14-eicosadienamide + H2O
? + NH3
-
127% of the activity with oleamide
-
-
?
2,2-dimethyloleamide + H2O
2,2-dimethyloleic acid + NH3
-
3% of the activity with oleamide
-
-
?
2-arachidonoylglycerol + H2O
?
2-methyloleamide + H2O
2-methyloleic acid + NH3
-
7% of the activity with oleamide
-
-
?
2-oleoylglycerol + H2O
?
-
-
-
-
?
8,11,14-eicosatrienamide + H2O
8,11,14-eicosatrienoic acid + NH3
-
138% of the activity with oleamide
-
-
?
all-trans-anandamide + H2O
ethanolamine + arachidonic acid
-
all-trans-anandamide is an equally good substrate for rabbit platelet FAAH compared to anandamide
-
-
?
alpha-linolenamide + H2O
? + NH3
-
138% of the activity with oleamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
anandamide + H2O
ethanolamine + arachidonic acid
arachidonamide + H2O
arachidonic acid + NH3
arachidonoyl 7-amido-4-methylcoumarin + H2O
arachidonic acid + 7-amino-4-methylcoumarin
arachidonoyl ethanolamide + H2O
arachidonic acid + ethanolamine
arachidonoyl p-nitroanilide + H2O
arachidonate + p-nitroaniline
-
-
-
-
?
arachidonyl-7-amino-4-methylcoumarin amide + H2O
arachidonic acid + 7-amino-4-methylcoumarin
beta-arachidonoylglycerol + H2O
?
-
hydrolysis is 2.5fold higher than the rate of anandamide hydrolysis
-
-
?
decanoyl 7-amido-4-methylcoumarin + H2O
?
decanoyl p-nitroanilide + H2O
decanoate + p-nitroaniline
-
-
-
-
?
dodecanoamide + H2O
dodecanoic acid + NH3
-
74% of the activity with oleamide
-
-
?
erucamide + H2O
? + NH3
-
83% of the activity with oleamide
-
-
?
heptanoyl p-nitroanilide + H2O
heptanoate + p-nitroaniline
-
-
-
-
?
lauroyl p-nitroanilide + H2O
laurate + p-nitroaniline
-
-
-
-
?
linoelaidamide + H2O
(9E,12E)-octadeca-9,12-dienoic acid + NH3
-
54% of the activity with oleamide
-
-
?
myristic amide + H2O
myristic acid + NH3
myristoyl p-nitroanilide + H2O
myristate + p-nitroaniline
-
-
-
-
?
N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
4-(pyren-1-yl)butanamide + ethylene glycol
-
-
-
?
N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
4-pyren-1-ylbutanoic acid + ?
-
-
-
-
?
N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
?
-
-
-
-
?
N-(2-hydroxyethyl)linoleoylamide + H2O
?
-
-
-
-
?
N-(2-hydroxyethyl)octadecanamide + H2O
?
-
hydrolyzed at 15.0% the rate of anandamide
-
-
?
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide + H2O
4-amino-m-cresol + NH3
-
the rate of metabolism of VDM11 is about 1520% of that for anandamide
-
-
?
N-(4-nitrophenyl)decanamide + H2O
?
-
-
-
-
?
N-(4-nitrophenyl)octanamide + H2O
?
-
-
-
-
?
N-(6-methoxypyridin-3-yl)decanamide + H2O
?
-
-
-
-
?
N-(6-methoxypyridin-3-yl)octanamide + H2O
?
-
-
-
-
?
N-(o-hydroxyphenyl)arachidonamide + H2O
?
-
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
N-oleoyltaurine + H2O
taurine + oleic acid
4% of the activity with anandamide
-
-
?
N-palmitoyl ethanolamine + H2O
palmitic acid + ethanolamine
-
-
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
nervonamide + H2O
? + NH3
-
82% of the activity with oleamide
-
-
?
nonanoyl p-nitroanilide + H2O
nonanoate + p-nitroaniline
-
-
-
-
?
octanoyl p-nitroanilide + H2O
octanoate + p-nitroaniline
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
oleoyl ethanolamide + H2O
oleic acid + ethanolamine
oleoyl methyl amide + H2O
?
-
-
-
-
?
oleoyl methyl ester + H2O
?
-
-
-
-
?
oleoyl methyl ester + H2O
oleic acid + methanol
-
-
-
-
?
oleoyl p-nitroanilide + H2O
?
-
-
-
-
?
oleoyl p-nitroanilide + H2O
oleate + p-nitroaniline
-
-
-
-
?
oleoylethanolamide + H2O
oleic acid + ethanolamine
palmitic amide + H2O
palmitic acid + NH3
palmitoamide + H2O
palmitic acid + NH3
-
72% of the activity with oleamide
-
-
?
palmitoleamide + H2O
palmitoleic acid + NH3
-
79% of the activity with oleamide
-
-
?
palmitoyl p-nitroanilide + H2O
palmitate + p-nitroaniline
-
-
-
-
?
palmitoylethanolamide + H2O
palmitic acid + ethanolamine
-
substrate of FAAH and FAAH-2, the latter shows lower activity than FAAH
-
-
?
stearamide + H2O
stearic acid + NH3
-
69% of the activity with oleamide
-
-
?
stearic amide + H2O
stearic acid + NH3
additional information
?
-
2-arachidonoylglycerol + H2O
?
-
FAAH is responsible for approximately one-half of the 2-arachidonoylglycerol hydrolysis occurring in BV-2 cell homogenate
-
-
?
2-arachidonoylglycerol + H2O
?
-
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide, LC-MS/MS analysis
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
substrate of FAAH and FAAH-2, the latter shows lower activity than FAAH
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. N-arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide, LC-MS/MS analysis
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. N-arachidonoylethanolamine
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
FAAH-1 plays a primary role in regulating endocannabinoid signaling
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
5% of the activity with oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
anandamide hydrolysis in BV-2 cells is entirely attributable to FAAH
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
the enzyme cleaves anandamide and regulates in vivo the magnitude and duration of the signaling induced by this lipid messenger
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
the enzyme is responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
168% of the activity with oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
arachidonamide + H2O
arachidonic acid + NH3
-
-
-
-
?
arachidonamide + H2O
arachidonic acid + NH3
-
311% of the activity with oleamide
-
-
?
arachidonoyl 7-amido-4-methylcoumarin + H2O
arachidonic acid + 7-amino-4-methylcoumarin
-
-
-
-
?
arachidonoyl 7-amido-4-methylcoumarin + H2O
arachidonic acid + 7-amino-4-methylcoumarin
-
-
-
-
?
arachidonoyl ethanolamide + H2O
arachidonic acid + ethanolamine
-
-
-
?
arachidonoyl ethanolamide + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
arachidonyl-7-amino-4-methylcoumarin amide + H2O
arachidonic acid + 7-amino-4-methylcoumarin
fluorogenic substrate
-
-
?
arachidonyl-7-amino-4-methylcoumarin amide + H2O
arachidonic acid + 7-amino-4-methylcoumarin
fluorogenic substrate
-
-
?
decanoyl 7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
decanoyl 7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
myristic amide + H2O
myristic acid + NH3
65% of the activity with anandamide
-
-
?
myristic amide + H2O
myristic acid + NH3
-
24.3% of the activity with oleamide
-
-
?
myristic amide + H2O
myristic acid + NH3
-
24% of the activity with anandamide
-
-
?
myristic amide + H2O
myristic acid + NH3
-
83% of the activity with oleamide
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
?
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
-
-
-
?
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
23% of the activity with oleamide
-
-
?
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
33% of the activity with anandamide
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
-
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
12% of the activity with anandamide
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
2.3% of the activity with oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
?
oleamide + H2O
oleic acid + NH3
57% of the activity with anandamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
role of FAAH in epithelial cells of the choroid plexus may be to control the concentration of oleamide in the cerebrospinal fluid. FAAH may exert an important regulatory role in shaping the duration and magnitude of the sleep-inducing effect of endogenously or exogenously derived oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
the enzyme is responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers
-
-
?
oleamide + H2O
oleic acid + NH3
-
serine residue 241 acts as the catalytic nucleophile of the enzyme. FAAH does not utilize a histidine base for the activation of its serine nucleophile
-
-
?
oleamide + H2O
oleic acid + NH3
i.e. cis-9-octadecenamide
-
-
?
oleoyl ethanolamide + H2O
oleic acid + ethanolamine
-
-
-
?
oleoyl ethanolamide + H2O
oleic acid + ethanolamine
-
-
-
-
?
oleoylethanolamide + H2O
oleic acid + ethanolamine
-
-
-
?
oleoylethanolamide + H2O
oleic acid + ethanolamine
-
-
-
?
palmitic amide + H2O
palmitic acid + NH3
33% of the activity with anandamide
-
-
?
palmitic amide + H2O
palmitic acid + NH3
-
10% of the activity with anandamide
-
-
?
palmitic amide + H2O
palmitic acid + NH3
-
9.9% of the activity with oleamide
-
-
?
stearic amide + H2O
stearic acid + NH3
5.8% of the activity with anandamide
-
-
?
stearic amide + H2O
stearic acid + NH3
-
5.8% of the activity with anandamide
-
-
?
stearic amide + H2O
stearic acid + NH3
-
5.8% of the activity with oleamide
-
-
?
additional information
?
-
-
the substrate specificity of fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton
-
-
?
additional information
?
-
no activity with N-oleoyltaurine
-
-
?
additional information
?
-
no activity with N-oleoyltaurine
-
-
?
additional information
?
-
-
no activity with N-oleoyltaurine
-
-
?
additional information
?
-
-
FAAH inactivates anandamide and other bioactive N-acylethanolamines
-
-
?
additional information
?
-
-
the substrate specificity of fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton
-
-
?
additional information
?
-
FAAH is the primary N-arachidonoylethanolamine-degrading enzyme, but it is also capable of hydrolyzing other bioactive N-acylethanolamines, such as N-palmitoylethanolamine, N-oleoylethanolamine and the sleep-inducing lipid oleamide
-
-
?
additional information
?
-
-
catalytic efficiency (kcat/Km) of FAAH for nonanoyl p-nitroanilide is approximately 50fold higher than for hexanoyl p-nitroanilide. NAI491 participates in hydrophobic binding interactions with medium-chain FAAH substrates. Use of p-nitroanilide substrates allows for the precise monitoring of enzymatic hydrolysis rates by following the increase in UV absorbance at 382 nm due to the release of p-nitroaniline. p-Nitroanilides are slower FAAH substrates than the corresponding primary amides, however, the binding affinities of these two classes of substrates are equivalent. Due to the slower rates of p-nitroanilide hydrolysis relative to the corresponding primary amides, it can be assumed that pNA substrates are hydrolyzed by FAAH in an acylation rate-limiting manner, allowing for the direct measurement of substrate binding constants through the determination of Km values
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additional information
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FAAH is an enzyme of broad substrate specificity and is capable of hydrolyzing a wide array of unsaturated, and to a lesser extent saturated, fatty acid primary amides. However, when substituted adjacent to the amide carbonyl, the substrates can be made sterically or electronically resistant to hydrolysis. Long chain saturated fatty acid amides are hydrolyzed slower than the corresponding Z unsaturated fatty acid amides and the rate of hydrolysis increases incrementally with increases in the degree of unsaturation
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additional information
?
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hybrid quantum mechanics/molecular mechanics (QM/MM) calculations reveal a new mechanism of nucleophile activation involving a LysSerSer catalytic triad. The proposed mechanism, shows that Lys142 and cis-Ser217 have a direct role in the activation of Ser241, in agreement with kinetic labelling experiments employing the highly reactive fluorophosphonatetetramethyl rhodamine. The greater reduction of Ser241 labelling rate in the K142A/S217A double mutant, compared to the K142A and S217A single mutants, suggests that Lys142 and Ser217 cooperate to deprotonate Ser241
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additional information
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N,N-bis(2-hydroxyethyl)arachidonamide is not hydrolyzed
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(1-benzhydryltriazol-4-yl)methyl N-cyclohexylcarbamate
73% inhibition at 0.1 mM
(1-benzothiophen-6-ylamino)([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)methanone
-
-
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
(1-benzyltriazol-4-yl)methyl N-cyclohexylcarbamate
-
(1-phenethyltriazol-4-yl)methyl N-cyclohexylcarbamate
-
(1-phenyltriazol-4-yl)methyl N-cyclohexylcarbamate
-
(10Z)-1,1,1-trifluorononadec-10-en-2-one
-
-
(10Z)-1-bromononadec-10-en-2-one
-
-
(10Z)-2-oxononadec-10-enamide
-
-
(1H-benzo[d][1,2,3]triazol-1-yl)(4-(3-phenoxybenzyl)-piperazin-1-yl)-methanone
-
(1H-benzo[d][1,2,3]triazol-1-yl)(4-(4-phenoxybenzyl)-piperazin-1-yl)-methanone hydrochloride
-
(1H-imidazol-1-yl)(4-(3-phenoxybenzyl)piperazin-1-yl)methanone
-
(1H-imidazol-1-yl)(4-(4-phenoxy-benzyl)-piperazin-1-yl)-methanone hydrochloride
-
(2R)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(2S)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(3-phenylphenyl)methyl N-cyclohexylcarbamate
65% inhibition at 0.1 mM
(3H-[1,2,3]triazol[4,5-b]pyridin-3-yl)(4-(3-phenoxybenzyl)-piperazin-1-yl)-methanone
-
(3R,4R)-4-acetoxy-3-((10R)-(t-butyldimethylsilyloxy)-ethyl)-azetidin-2-one
-
(4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)-piperidin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
-
(4-benzhydrylpiperazin-1-yl)(4-phenyl-1H-imidazol-1-yl)methanone
62% activity remaining at 0.01 mM
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
(4-phenylpiperazin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
-
(5-iodo-1,3-oxazol-2-yl)[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
(5-iodo-1,3-oxazol-2-yl)[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
(5E)-5-(4-methoxybenzylidene)-3-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1,3-thiazolidine-2,4-dione
-
-
(5Z,8Z,11Z,14Z)-1-pyridazin-3-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
-
-
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
-
i.e. (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide or N-arachidonoylethanolamine, competitive
(5Z,8Z,11Z,14Z)-N-[(2R)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
-
-
(5Z,8Z,11Z,14Z)-N-[(2S)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
-
-
(6aR,10aR)-3-(1,1-dimethylheptyl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
-
-
(6E,9E,12E,15E)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
-
(9E)-1-pyridazin-3-yloctadec-9-en-1-one
-
-
(9E)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-(1,3-benzothiazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1,3-oxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1,3-thiazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1-methyl-1H-benzimidazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1-methyl-1H-imidazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1-methyl-1H-tetrazol-5-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1H-benzimidazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1H-tetrazol-5-yl)octadec-9-en-1-one
-
-
(9Z)-1-(2-methyl-2H-tetrazol-5-yl)octadec-9-en-1-one
-
-
(9Z)-1-(4,5-dihydro-1,3-oxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(4-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(5-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(6-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(7-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-phenyloctadec-9-en-1-one
-
-
(9Z)-1-pyrazin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-pyridazin-3-yloctadec-9-en-1-one
-
-
(9Z)-1-pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-pyrimidin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-pyrimidin-4-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[5,4-b]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-yloctadec-9-en-1-one
-
-
(benzyl-1,2,4-triazol-3-yl)methyl N-cyclohexylcarbamate
-
(dodecylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
(phenylamino)[[(4-phenylcyclohexylidene)amino]oxy]methanone
-
-
(phenylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
(phenylamino)[[(E)-[1-[4-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl 2-(biphenyl-4-yl)acetate
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl 3-(1H-indol-3-yl)propanoate
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl biphenyl-4-carboxylate
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl-4-phenylbutanoate
-
([(E)-[1-(2,2'-bithiophen-5-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(4-cyclohexylphenyl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(diphenylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(phenylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(piperidin-1-yl)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-fluorophenyl)amino]methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-methoxyphenyl)amino]methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(5-phenylpentyl)amino]methanone
-
-
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(dimethylamino)methanone
-
-
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(phenylamino)methanone
-
-
1,1'-(5,5'-bi-1,3-oxazole-2,2'-diyl)bis(7-phenylheptan-1-one)
-
-
1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
-
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
1,1-biphenyl-3-yl-carbamic acid cyclohexyl ester
-
i.e. URB602
1,2,3,4-tetrahydronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
59.6% inhibition at 0.01 mM
1,3-benzodioxol-5-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
1,3-oxazol-2-yl[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]methanone
-
1,3-oxazol-2-yl[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]methanone
-
1,3-oxazol-2-yl[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
1,3-oxazol-2-yl[(3R)-7-phenyl-3,4-dihydro-2H-chromen-3-yl]methanone
-
1,3-oxazol-2-yl[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
1,3-oxazol-2-yl[(3S)-7-phenyl-3,4-dihydro-2H-chromen-3-yl]methanone
-
1-(1,3-benzoxazol-2-yl)octadecan-1-one
-
-
1-(1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(1-phenyl-1,2,4-triazol-3-yl)methyl N-cyclohexylcarbamate
70% inhibition at 0.1 mM
1-(1H-benzimidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
1-(1H-benzotriazol-1-yl)-3-[(3'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(3'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(4'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]butan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[(4-phenoxyphenyl)thio]propan-2-one
-
1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]pentan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]propan-2-one
-
-
1-(1H-imidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-imidazo[4,5-b]pyridin-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-indazol-1-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(1H-indazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
-
-
1-(2-oxo-3-[4-[4-(trifluoromethyl)phenoxy]phenoxy]propyl)-1H-indole-5-carboxylic acid
-
21% inhibition at 0.01 mM
1-(2-oxo-3-[[4'-(propan-2-yl)biphenyl-4-yl]oxy]propyl)-1H-indole-5-carboxylic acid
-
-
1-(3H-imidazo[4,5-b]pyridin-3-yl)-3-(4-octylphenoxy)propan-2-one
-
-
1-(4-benzylpiperazin-1-yl)-2-[4-(2-methylpropyl)phenyl]propan-1-one
18% inhibition at 0.1 mM
1-(4-octylphenoxy)-3-(1H-1,2,4-triazol-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-pyrazol-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-pyrazolo[3,4-b]pyridin-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-pyrazolo[4,3-b]pyridin-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-tetrazol-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(1H-[1,2,3]triazolo[4,5-b]pyridin-1-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(2H-1,2,3-triazol-2-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)propan-2-one
-
-
1-(4-octylphenoxy)-3-[5-(1H-tetrazol-5-yl)-1H-indol-1-yl]propan-2-one
-
-
1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one
-
-
1-(5-acetyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-bromo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-chloro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-fluoro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-furan-2-yl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-iodo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-methyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-nitro-1H-indazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
-
-
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
1-benzothiophen-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one
-
-
1-pyridazin-3-yloctadecan-1-one
-
-
1-[(3R)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
-
-
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl (benzyloxy)acetate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 3-(1H-indol-3-yl)propanoate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 4-(pyridin-2-yl)butanoate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 4-(pyridin-4-yl)butanoate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl biphenyl-4-carboxylate
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl biphenyl-4-ylacetate
-
1-[([1,1'-biphenyl]-4-yl)oxy]-3-(1H-tetrazol-1-yl)propan-2-one
-
-
1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)butan-2-one
-
-
1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)propan-2-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-4-phenylbutan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-5-phenylpentan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-6-phenylhexan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-7-phenylheptan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-8-phenyloctan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-9-phenylnonan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-en-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-yn-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldodecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylethanone
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylheptan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexadecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-yn-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylpentan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yltetradecan-1-one
-
-
1-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1H-benzimidazole-7-carboxylic acid
-
-
1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazole-5-carboxylic acid
-
-
1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
-
-
1-[2-oxo-3-[4-(2-phenoxyethoxy)phenoxy]propyl]-1H-indole-5-carboxylic acid
-
-
1-[2-oxo-3-[4-(2-phenylpropan-2-yl)phenoxy]propyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-benzylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indazole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid
1-[3-(biphenyl-2-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(biphenyl-3-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(biphenyl-4-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
39% inhibition at 0.01 mM
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
1-[3-[(4'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(4-fluorophenyl)phenoxy]-2-oxopropyl]indazole-5-carboxylic acid
-
-
1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(heptyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(hexyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(nonyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(octyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(2-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
33% inhibition at 0.1 mM
1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(3-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
41% inhibition at 0.1 mM
1-[4-(3-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(4-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(4-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-[(3-chlorophenyl)methyl]piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
8% inhibition at 0.1 mM
1-[4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidin-1-yl]-3,3,3-trifluoro-2-(trifluoromethyl)propan-1-one
-
1-[5-(2,4-dimethoxypyrimidin-5-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2,6-dimethoxypyrimidin-4-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-benzyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-(3-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-aminopyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-fluoropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methoxypyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-nitropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(5-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(6-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(methylsulfanyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(morpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(morpholin-4-ylcarbonyl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-[(4-methylpiperazin-1-yl)carbonyl]-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1H-benzimidazol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
1H-benzotriazol-1-yl[4-(diphenylmethyl)piperazin-1-yl]methanone
-
1H-indol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
2,2,2-trichloroethyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate
-
2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2,3-dihydro-1,4-benzodioxin-5-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
2-(1-benzyltriazol-4-yl)ethyl N-cyclohexylcarbamate
-
2-(1-phenyltriazol-4-yl)ethyl N-cyclohexylcarbamate
-
2-(1H-benzotriazol-1-yl)-1-(5-phenoxy-1,3-benzoxazol-2-yl)ethan-1-one
-
-
2-(2-fluorobiphenyl-4-yl)-N-(2-(3-methylpyridin-2-ylamino)-2-oxoethyl)propanamide
-
2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide
mode of inhibition, overview. Flu-AM1 does not inhibit the enzyme from brain in vivo
2-(4-cyclohexylphenoxy)-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[4-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2-(6-methoxynaphthalen-2-yl)-N-(3-methylpyridin-2-yl)propanamide
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carbaldehyde
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carbonitrile
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylic acid
-
-
2-(methylamino)-2-oxoethyl [2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate
2-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
2-hydroxy-N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]acetamide
-
-
2-iodobenzylarachidonoylamide
-
-
2-iodobenzyllinoleoylamide
-
-
2-iodophenethylarachidonoylamide
-
-
2-iodophenethyllinoleoylamide
-
-
2-methoxy-N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]acetamide
-
-
2-methoxyphenethylarachidonoylamide
-
-
2-methoxyphenethyllinoleoylamide
-
-
2-methyl-N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylic acid
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carbonitrile
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylic acid
-
-
2-[4-(2-methylpropyl)phenyl]-1-(4-phenylpiperazin-1-yl)propan-1-one
-
2-[4-(2-methylpropyl)phenyl]-N-(3-methylpyridin-2-yl)propanamide
-
2-[4-(2-methylpropyl)phenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]propanamide
-
2-[4-(2-methylpropyl)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2H-benzotriazol-2-yl(4-phenylpiperazin-1-yl)methanone
-
2H-benzotriazol-2-yl[4-(diphenylmethyl)piperazin-1-yl]methanone
-
3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate
-
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
-
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide
-
-
3-(1H-benzotriazol-1-yl)-1-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
-
-
3-iodobenzylarachidonoylamide
-
-
3-iodobenzyllinoleoylamide
-
-
3-iodophenethylarachidonoylamide
-
-
3-iodophenethyllinoleoylamide
-
-
3-methoxyphenethylarachidonoylamide
-
-
3-methoxyphenethyllinoleoylamide
-
-
3-phenylpropane-1-sulfonyl fluoride
-
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
3-[([1,1'-biphenyl]-4-yl)oxy]-1-(1H-tetrazol-1-yl)butan-2-one
-
-
3-[([1,1'-biphenyl]-4-yl)oxy]-1-(2H-tetrazol-2-yl)butan-2-one
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
4-(3-phenoxybenzyl)-N-(4-methoxyphenyl)piperazine-1-carboxamide
-
4-(3-phenoxybenzyl)-N-(4-nitrophenyl)piperazine-1-carboxamide
-
4-(3-phenoxybenzyl)-N-phenylpiperazine-1-carboxamide
-
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
4-(4-benzyloxyphenoxy)butanesulfonyl fluoride
-
4-(acetylamino)phenyl (4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetate
-
-
4-(acetylamino)phenyl 2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
-
competitive, also able to inhibit the FAAH activity in rat basophilic leukemia cells as assessed by measuring either the hydrolysis of anandamide, the FAAH-dependent cellular accumulation of anandamide, or the FAAH-dependent recycling of tritium to the cellmembranes
4-(acetylamino)phenyl 2-[[2-(trifluoromethyl)pyridin-4-yl]amino]pyridine-3-carboxylate
-
-
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate
-
-
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylate
-
-
4-(acetylamino)phenyl 2-{[2-(trifluoromethyl)pyridin-4-yl]amino}benzoate
-
-
4-(acetylamino)phenyl 3-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
-
-
4-(acetylamino)phenyl 3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 3-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 4-([[2-(trifluoromethyl)pyridin-4-yl]amino]methyl)benzoate
-
-
4-(acetylamino)phenyl 4-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 5-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 5-methyl-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl N-(3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
-
-
4-(acetylamino)phenyl N-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
-
-
4-(acetylamino)phenyl N-[(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetyl]glycinate
-
-
4-(acetylamino)phenyl N-[2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoyl]glycinate
-
-
4-(benzyloxy)phenyl butylcarbamate
-
4-benzhydryl-N-(4-(trifluoromethyl)phenyl)piperazine-1-carboxamide
86% activity remaining at 0.01 mM
4-benzhydryl-N-(4-butylphenyl)piperazine-1-carboxamide
84% activity remaining at 0.01 mM
4-benzhydryl-N-(4-methoxyphenyl)piperazine-1-carboxamide
89% activity remaining at 0.01 mM
4-benzhydryl-N-(4-nitrophenyl)piperazine-1-carboxamide
84% activity remaining at 0.01 mM
4-benzhydryl-N-(pyridin-2-yl)piperazine-1-carboxamide
87% activity remaining at 0.01 mM
4-benzhydryl-N-(pyridin-3-yl)piperazine-1-carboxamide
87% activity remaining at 0.01 mM
4-benzhydryl-N-phenylpiperazine-1-carboxamide
88% activity remaining at 0.01 mM
4-carbamoylnaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
4-fluoronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
4-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
4-hydroxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
4-iodobenzylarachidonoylamide
-
-
4-iodobenzyllinoleoylamide
-
-
4-iodophenethylarachidonoylamide
-
-
4-iodophenethyllinoleoylamide
-
-
4-methoxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
4-methoxyphenethylarachidonoylamide
-
-
4-methoxyphenethyllinoleoylamide
-
-
4-methoxyphenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
-
4-nitrophenyl 4-(diphenylmethyl)piperazine-1-carboxylate
-
4-nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate
-
4-nitrophenyl 4-[bis(4-fluorophenyl)methyl]piperazine-1-carboxylate
-
4-nitrophenyl-4-(4-phenoxy-benzyl)-piperazine-1-carboxylate
-
4-nitrophenyl-4-(bis(benzo[d][1,3]dioxol-5-yl)methyl)piperidine-1-carboxylate
-
4-phenylbutane-1-sulfonyl fluoride
-
4-[([4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamoyl)oxy]naphthalene-1-carboxylic acid
-
-
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
4-[3-(4-chlorophenoxy)benzyl]-N-(pyridin-3-yl)piperazine-1-carboxamide
4-[3-[4-(decyloxy)phenoxy]-2-oxopropoxy]benzoic acid
-
-
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
5,6,7,8-tetrahydronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
5-(4-benzyloxyphenyl)pentanesulfonyl fluoride
-
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-morpholin-4-yl-1H-pyrazole-3-carboxamide
-
-
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
5-phenylpentane-1-sulfonyl fluoride
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylic acid
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylic acid
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-sulfonamide
-
-
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
6-hydroxybiphenyl-3-yl cyclohexylcarbamate
6-phenylhexane-1-sulfonyl fluoride
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxamide
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione
-
-
7-(2-benzyloxyphenyl)heptanesulfonyl fluoride
-
7-(2-hydroxyphenyl)heptanesulfonyl fluoride
-
7-(3-benzyloxyphenyl)heptanesulfonyl fluoride
-
7-(3-hydroxyphenyl)heptanesulfonyl fluoride
-
7-(4-benzyloxyphenyl)heptane-1-sulfonic acid methyl ester
-
7-(4-benzyloxyphenyl)heptanesulfonyl fluoride
-
7-(4-hydroxyphenyl)heptanesulfonyl fluoride
-
7-phenyl-1-(5-phenyl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
7-phenyl-1-(5-pyrimidin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyrimidin-4-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyrimidin-5-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-thiophen-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-[5-(1H-tetrazol-5-yl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(piperidin-1-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
7-phenyl-1-[5-(thiomorpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(trifluoroacetyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[2-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[3-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[4-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[4-(trifluoromethyl)pyridin-2-yl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenylheptane-1-sulfonyl fluoride
-
8-phenyloctane-1-sulfonyl fluoride
-
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
benzyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)-piperidine-1-carboxylate
-
biphenyl-3-yl cyclohexylcarbamate
cis-anandamide
-
inhibits hydrolysis of anandamide
cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester
-
i.e. URB597, attenuates the development of lipopolysaccharide-induced paw edema and reverses lipopolysaccharide-induced hyperalgesia through the respective CB2 and CB1 mechanisms of action. The inhibition is not affected by capsazepine, a transient receptor potential vanilloid type 1 antagonist
decyl benzodioxaphosphorin oxide
-
-
diisopropyl fluorophosphate
-
-
dodecyl benzodioxaphosphorin oxide
-
-
dodecyl sulfonyl fluoride
-
-
dodecyl-benzodioxaphosphorin oxide
-
-
ethoxy oleoyl fluorophosphonate
-
irreversible inhibitor, exclusively modifies FAAH at S241
ethyl (10Z)-2-oxononadec-10-enoate
-
-
ethyl 4-(1H-1,2,4-triazol-1-ylcarbonyl)piperazine-1-carboxylate
-
ethyl 4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-ylcarbonyl)piperazine-1-carboxylate
-
ethyl octylphosphonofluoridate
-
-
heptyl benzodioxaphosphorin oxide
-
-
hexadecyl sulfonylfluoride
isopropyl dodecylfluorophosphate
-
-
methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate
-
-
methyl 2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylate
-
-
methyl 3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylate
-
-
methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylate
-
-
methyl 6-(2-[[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-(2-[[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-(2-[[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-(2-[[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl arachidonoyl fluorophosphonate
methyl arachidonyl fluorophosphonate
methyl arachidonyl phosphonofluoridate
-
-
methyl arachidonylfluoroposphate
-
-
methyl octylphosphonofluoridate
-
-
methyl [1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamate
-
-
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
N,N-dimethyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N-(1,4-dihydroquinolin-8-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(2-hydroxyethyl)linoleoylamide
-
competitive versus anadamide
N-(2-methylphenyl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
N-(3-bromopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-chloropyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-iodopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclobutane-1-carboxamide
-
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclohexane-1-carboxamide
30% inhibition at 0.1 mM
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopentane-1-carboxamide
-
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopropane-1-carboxamide
-
N-(3-methylpyridin-2-yl)-2-(4'-isobutylphenyl)propionamide
-
i.e. Ibu-am5
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[8-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
-
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide
-
i.e. VDM11, inhibits the metabolism of anandamide by rat brain FAAH. Inhibition may at least in part be a consequence of the compound acting as an alternative substrate
N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
-
i.e. AM404, a bioactive N-acylphenolamine, derived from paracetamol, competitve inhibition
N-(4-hydroxyphenyl)arachidonylamide
-
i.e. AM404, inhibits the metabolism of anandamide by rat brain FAAH
N-(4-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(5-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(phenylcarbamoyl)-3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide
-
-
N-(pyrazin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyridazin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzylidene)piperidine-1-carboxamide
N-(pyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyridin-3-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyridin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzyl)piperidine-1-carboxamide
-
N-(pyridin-4-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyrimidin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
N-cyclohexyl-N'-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]urea
-
-
N-ethyl-N'-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]urea
-
-
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
N-methyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N-n-heptyl benzodioxaphosphorin oxide
-
-
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
N-phenyl-4-(3-phenyl-4,5-dihydro-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
N-[(2,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(2,5-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(2,6-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
19% inhibition at 0.1 mM
N-[(2-chlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(2-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(3,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(3-hydroxy-4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(pyridin-2-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[(pyridin-3-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]acetamide
-
-
N-[2-[(3-methylpyridin-2-yl)amino]-2-oxoethyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[3-(trifluoromethyl)pyridin-2-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-phenoxyacetamide
-
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-[4-(propan-2-yl)phenoxy]acetamide
-
N-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
24% inhibition at 0.1 mM
N-[4-(2-methylphenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
24% inhibition at 0.1 mM
N-[4-(4-chlorophenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
naphthalen-1-yl (3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propyl)carbamate
-
-
naphthalen-1-yl (4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]butyl)carbamate
-
-
naphthalen-1-yl [3-[4-(2,3-dichlorophenyl)piperazin-1-yl]propyl]carbamate
-
-
naphthalen-1-yl [3-[4-(3-methoxyphenyl)piperazin-1-yl]propyl]carbamate
-
-
naphthalen-1-yl [3-[4-(3-methylphenyl)piperazin-1-yl]propyl]carbamate
-
-
naphthalen-1-yl [4-[4-(3-methoxyphenyl)piperazin-1-yl]butyl]carbamate
-
-
naphthalen-1-yl [4-[4-(3-methylphenyl)piperazin-1-yl]butyl]carbamate
-
-
naproxen
38% inhibition at 0.1 mM
O-n-octyl benzodioxaphosphorin oxide
-
-
O-octyl-benzodioxaphosphorin oxide
-
-
octyl sulfonyl fluoride
-
-
octyl-benzodioxaphosphorin oxide
-
-
oleyl-benzodioxaphosphorin oxide
-
-
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
oxiran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
oxiran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
oxiran-2-ylmethyl benzoate
-
-
PF-04457845
potently inhibits the enzyme regardless the route selected
phenyl ([4-[(5-phenyl-2H-tetrazol-2-yl)methyl]phenyl]methyl)carbamate
-
phenyl 4-[(1H-indol-1-yl)methyl]piperidine-1-carboxylate
-
phenyl 4-[2-(1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(4-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-chloro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-cyano-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-methoxy-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-methyl-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperazine-1-carboxylate
-
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(7-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(9H-carbazol-9-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[3-(1H-indol-1-yl)propyl]piperidine-1-carboxylate
-
phenyl 4-[4-(1H-indol-1-yl)butyl]piperidine-1-carboxylate
-
phenyl [1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamate
-
-
phenyl [2-[2-(5-phenyl-2H-tetrazol-2-yl)ethoxy]ethyl]carbamate
-
phenyl [4-(1H-indol-1-yl)butyl]carbamate
-
phenyl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
-
-
phenyl [5-(1H-indol-1-yl)pentyl]carbamate
-
phenyl [5-(2-phenyl-1H-imidazol-1-yl)pentyl]carbamate
-
phenyl [5-(5-phenyl-2H-tetrazol-2-yl)pentyl]carbamate
-
phenyl [6-(1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(1H-indol-1-yl)hexyl]carbamate
-
phenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(2-phenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(4-phenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(5-benzyl-2H-tetrazol-2-yl)hexyl]carbamate
-
phenyl [6-(5-phenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(5-phenyl-1H-tetrazol-1-yl)hexyl]carbamate
-
phenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
phenyl [6-[2-(3-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(3-fluorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(3-methoxyphenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(3-methylphenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(4-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[5-(2-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(3-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(4-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(pyridin-2-yl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(pyridin-3-yl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(pyridin-4-yl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [7-(1H-indol-1-yl)heptyl]carbamate
-
phenyl [7-(2-phenyl-1H-imidazol-1-yl)heptyl]carbamate
-
phenyl [7-(5-phenyl-2H-tetrazol-2-yl)heptyl]carbamate
-
phenyl [8-(1H-indol-1-yl)octyl]carbamate
-
phenyl [8-(2-phenyl-1H-imidazol-1-yl)octyl]carbamate
-
phenyl [8-(5-phenyl-2H-tetrazol-2-yl)octyl]carbamate
-
phenyl-benzodioxaphosphorin oxide
-
-
phenylmethane sulfonyl fluoride
irreversible inhibition
piperidin-1-yl[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
pyridin-3-yl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
S-heptyl benzodioxaphosphorin oxide
-
-
S-nonyl benzodioxaphosphorin oxide
-
-
S-pentyl benzodioxaphosphorin oxide
-
-
stearyl benzodioxaphosphorin oxide
-
-
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl benzoate
-
-
tetrahydro-2H-pyran-4-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
trans-anandamide
-
inhibits hydrolysis of anandamide
[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl (benzyloxy)acetate
-
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl 4-(pyridin-2-yl)butanoate
-
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl 4-(pyridin-4-yl)butanoate
-
[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3R)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl](1,3-oxazol-2-yl)methanone
-
[(3R)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3R)-7-phenyl-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3S)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl](1,3-oxazol-2-yl)methanone
-
[(3S)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3S)-7-phenyl-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
[1-(2-naphthylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]cyanamide
-
-
-
[1-(m-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-(o-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-(p-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-fluoro-3-methoxy-phenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(4-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(4-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[4-(3-phenoxybenzyl)piperazin-1-yl](1H-1,2,4-triazol-1-yl)methanone
-
[4-(diphenylmethyl)piperazin-1-yl](1H-1,2,4-triazol-1-yl)methanone
-
[4-(diphenylmethyl)piperazin-1-yl](1H-imidazol-1-yl)methanone
-
[4-[bis(1,3-benzodioxol-5-yl)methyl]piperidin-1-yl](1H-1,2,4-triazol-1-yl)methanone
-
[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl](1H-1,2,4-triazol-1-yl)methanone
-
[[(E)-[1-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]ethylidene]amino]oxy](naphthalen-1-ylamino)methanone
-
-
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
-
-
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
-
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
-
-
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
-
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
-
-
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
-
-
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
the compound belongs to the ketobenzimidazoles, though containing a carbonyl moiety, that do not covalently modify Ser241. These inhibitors achieve potent inhibition of FAAH activity primarily from shape complementarity to the active site and through numerous hydrophobic interactions exhibiting excellent selectivity and good pharmacokinetic properties, nonmechanism-based inhibition
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
the compound belongs to the ketobenzimidazoles, though containing a carbonyl moiety, that do not covalently modify Ser241. These inhibitors achieve potent inhibition of FAAH activity primarily from shape complementarity to the active site and through numerous hydrophobic interactions exhibiting excellent selectivity and good pharmacokinetic properties, nonmechanism-based inhibition. Pharmacokinetic parameters and selectivity 2, overview
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid
-
structure-activity relationship, overview
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
2-(methylamino)-2-oxoethyl [2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate
-
2-(methylamino)-2-oxoethyl [2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
exerts a combination of anxiolytic-like, anti-depressant-like, and analgesic effects, due to its ability to inhibit FAAH activity in the CNS and peripheral tissues. Covalent enzyme binding at Ser241 leading to irreversible inhibition, the attack at the carbonyl group by Ser 241 leads to the formation of carbamoylated, catalytically inactive FAAH and releasing the O-biphenyl moiety as the leaving group
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
irreversible inhibitor
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
-
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
covalent enzyme binding at Ser241 leading to irreversible inhibition, the attack at the carbonyl group by Ser 241 leads to the formation of carbamoylated, catalytically inactive FAAH and releasing the O-biphenyl moiety as the leaving group
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
-
-
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
-
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
i.e. ASP8477; i.e. ASP8477
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
i.e. ASP8477
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
-
-
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
-
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
-
JNJ-1661010
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[3-(4-chlorophenoxy)benzyl]-N-(pyridin-3-yl)piperazine-1-carboxamide
-
4-[3-(4-chlorophenoxy)benzyl]-N-(pyridin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
analgesic effect of 21d in rat inflammatory pain model, overview
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
i.e. AM3506, irreversible inhibitor for both the rat and the human enzyme, that covalently modifies the enzyme
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
i.e. AM3506, irreversible inhibitor for both the rat and the human enzyme
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
an irreversible covalent inhibitor, binding structure, overview
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
an irreversible covalent inhibitor, binding structure, overview
6-hydroxybiphenyl-3-yl cyclohexylcarbamate
-
6-hydroxybiphenyl-3-yl cyclohexylcarbamate
-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
-
OL-135, an alpha-keto-heterocycle that is a covalent reversible inhibitor of FAAH
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
reversible inhibitor
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
-
OL-135, an alpha-keto-heterocycle that is a covalent reversible inhibitor of FAAH
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
i.e. OL-135, the enzyme inhibitor exhibits antinociceptive and anti-inflammatory activity and increases levels of anandamide in vivo
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
biphenyl-3-yl cyclohexylcarbamate
-
biphenyl-3-yl cyclohexylcarbamate
-
CF3-OH
-
hexadecyl sulfonylfluoride
i.e. AM374, is a potent irreversible in vitro and in vivo inhibitor of fatty acid amide hydrolase
hexadecyl sulfonylfluoride
i.e. AM374, is a potent in vitro and in vivo inhibitor of fatty acid amide hydrolase
methyl arachidonoyl fluorophosphonate
-
methyl arachidonoyl fluorophosphonate
-
methyl arachidonyl fluorophosphonate
-
-
methyl arachidonyl fluorophosphonate
-
MAFP, a potent irreversible FAAH inhibitor
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-(pyridazin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzylidene)piperidine-1-carboxamide
-
N-(pyridazin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzylidene)piperidine-1-carboxamide
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
-
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
-
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
-
-
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
-
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
-
a reversible, albeit slowly dissociating inhibitor of FAAH, reversibly and noncovalently inhibiting, molecular docking and computational modeling of interactions of the benzothiazole analogue 1 with humanized rat FAAH by induced fit docking, overview. Failure to observe the formation of covalent enzyme-inhibitor adduct or putative cleavage product using electrospray mass spectrometric techniques
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
-
a reversible, albeit slowly dissociating inhibitor of FAAH, reversibly and noncovalently inhibiting, molecular docking and computational modeling of interactions of the benzothiazole analogue 1 with humanized rat FAAH by induced fit docking, overview. Failure to observe the formation of covalent enzyme-inhibitor adduct or putative cleavage product using electrospray mass spectrometric techniques
OL-135
-
OL-135
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
OL-135
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
oleoyl ethylamide
-
FAAH inhibitor
oleoyl ethylamide
-
FAAH inhibitor
oleoyl ethylamide
-
FAAH inhibitor
oleoyl oxazolopyridine
-
i.e. oloxa, a potent noncompetitive inhibitor, almost complete inhibition at 50 nM
oleoyl oxazolopyridine
-
, i.e. oloxa, a potent noncompetitive inhibitor, almost complete inhibition at 50 nM
palmitoyl ethanolamide
-
a non-CB1 non-CB2 cannabinoid-like compound
palmitoyl ethanolamide
-
a non-CB1 non-CB2 cannabinoid-like compound
palmitoyl ethanolamide
-
a non-CB1 non-CB2 cannabinoid-like compound
PF-3845
-
FAAH inhibitor, in vivo inhibition
PF-3845
crystal structure analysis of enzyme-inhibitor complex. The inhibitor interacts with the catalytic triad and oxyanion hole residues
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
-
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
-
URB597
-
URB597
-
a carbamate inhibiting FAAH covalently and irreversibly, time-dependent inhibition, overview
URB597
less effective inhibitor in the brain after oral administration while it reaches similar effects by intranasal (i.n.) and intraperitoneal routes. Intranasal URB597 delivery always increased N-acyl-ethanolamine levels in brain areas, whereas a parallel increase is not observed in the liver. By showing the efficacy of intranasal FAAH inhibition, evidence is provided that nose-to-brain delivery is a suitable alternative to enhance brain endocannabinoid tone for the treatment of neurodegenerative disorders and improve compliance of the patients
URB597
-
a carbamate inhibiting FAAH covalently and irreversibly, time-dependent inhibition, overview
URB597
a carbamate inhibitor that displays excellent selectivity for FAAH in the nervous system, although the inhibitor does inactivate additional peripheral hydrolases, enzyme-inhibitor binding structure, overview. The inhibitor interacts with the catalytic triad and oxyanion hole residues
VER-156084
-
a tetrasubstituted azetidine urea FAAH inhibitor
VER-156084
-
a tetrasubstituted azetidine urea FAAH inhibitor
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
-
-
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
additional information
-
fatty acid-derived FAAH inhibitors
-
additional information
-
analysis of the enzyme inhibition by quantum mechanics/molecular mechanics (QM/MM) modelling
-
additional information
-
mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles, long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency, transition-state analogues, overview
-
additional information
-
a series of oxime carbamates as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system
-
additional information
-
tetra-substituted azetidine ureas with in vivo activity as fatty acid amide hydrolase inhibitors, overview
-
additional information
-
1-(3-biaryloxy-2-oxopropyl)indole-5-carboxylic acids and related compounds can act as dual inhibitors of human cytosolic phospholipase A2alpha, EC 3.1.1.4, and fatty acid amide hydrolase, overview. Substituents at the indole 3- and 5-positions and replacement of the indole scaffold of this compound by other heterocycles strongly influences the inhibitory potency against FAAH
-
additional information
design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors, overview
-
additional information
piperazine and piperidine carboxamides and carbamates as enzyme inhibitors, molecular modeling, overview. Diverse leaving groups are tolerated for FAAH inhibitors
-
additional information
O-(triazolyl)methyl carbamates as potent fatty acid amide hydrolase inhibitors, overview
-
additional information
-
O-(triazolyl)methyl carbamates as potent fatty acid amide hydrolase inhibitors, overview
-
additional information
synthesis of a series of lipophilic ester derivatives of (S)-1-(pent-40-enoyl)-4-(hydroxymethyl)-azetidin-2-one in three steps from (S)-4-(benzyloxycarbonyl)-azetidin-2-one, evaluation as reversible, beta-lactamic inhibitors of endocannabinoid-degrading enzymes, fatty acid amide hydrolase and and monoacylglycerol lipase, docking studies, overview. No inhibition by 1b, 1d, and 1f
-
additional information
-
synthesis of a series of lipophilic ester derivatives of (S)-1-(pent-40-enoyl)-4-(hydroxymethyl)-azetidin-2-one in three steps from (S)-4-(benzyloxycarbonyl)-azetidin-2-one, evaluation as reversible, beta-lactamic inhibitors of endocannabinoid-degrading enzymes, fatty acid amide hydrolase and and monoacylglycerol lipase, docking studies, overview. No inhibition by 1b, 1d, and 1f
-
additional information
sulfonyl fluoride inhibitors of fatty acid amide hydrolase, structure-activity relationship, docking and molecular modeling, overview
-
additional information
-
sulfonyl fluoride inhibitors of fatty acid amide hydrolase, structure-activity relationship, docking and molecular modeling, overview
-
additional information
-
indazole-5-carboxylic acids with 3-aryloxy-2-oxopropyl residues in position 1 are reported to be potent dual inhibitors of cytosolic phospholipase A2alpha and fatty acid amide hydrolase. The carboxylic acid functionality of the lead compounds is of special importance for a pronounced inhibition of cytosolic phospholipase A2alpha and fatty acid amide hydrolase
-
additional information
-
the replacement of the activated ketone functionality of the fatty acid amide hydrolase inhibitors 1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one and 1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one, by a-ketoheterocycle, cyanamide, and nitrile is not well tolerated. The resulting compounds are only weakly or even not active against the enzyme
-
additional information
-
the microglial-specific isozyme is not inhibited by URB597, i.e. 3'-carbamoyl-biphenyl-3-ylcyclohexylcarbamate, and inhibitors of cyclooxygenases, lipooxygenases, and diacylglycerol lipases, overview
-
additional information
-
organophosphorus compound-induced FAAH inhibition and the associated anandamide accumulation may lead to reduced limb mobility as a secondary neurotoxic effect
-
additional information
-
synthesis of 18 aryl analogues of anandamide. In vitro evaluation of inhibitory potency, binding to CB1 and CB2 cannabinoid receptors, and potential as metabolic trapping tracers of 4-methoxyphenethyllinoleoylamide and 4-methoxyphenethylarachidonoylamide, overview
-
additional information
-
a series of 5-substituted 7-phenyl-1-(oxazol-2-yl)heptan-1-ones are prepared and evaluated for FAAH inhibitory potency as well as FAAH selectivity versus competitive serine proteases
-
additional information
-
paracetamol itself does not inhibit FAAH, but undergoes a FAAH-dependent two-step metabolic transformation in the brain, liver, and spinal cord to form the bioactive N-acylphenolamine AM404. Synthesis and evaluation of paracetamol ester enzyme inhibitors, structure-activity relationship studies, overview
-
additional information
-
mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles, long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency, transition-state analogues, overview
-
additional information
-
tetra-substituted azetidine ureas with in vivo activity as fatty acid amide hydrolase inhibitors, overview
-
additional information
-
1-(3-biaryloxy-2-oxopropyl)indole-5-carboxylic acids and related compounds can act as dual inhibitors of cytosolic phospholipase A2alpha, EC 3.1.1.4, and fatty acid amide hydrolase, overview. Substituents at the indole 3- and 5-positions and replacement of the indole scaffold of this compound by other heterocycles strongly influences the inhibitory potency against FAAH. No inhibition by 1-[3-(biphenyl-2-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid, N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide, N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide, 1-[5-(morpholin-4-ylcarbonyl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one, (5E)-5-(4-methoxybenzylidene)-3-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1,3-thiazolidine-2,4-dione, 1-[5-(3-benzyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one, 1-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one, 1-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1H-benzimidazole-7-carboxylic acid, and 1-(4-octylphenoxy)-3-[5-(1H-tetrazol-5-yl)-1H-indol-1-yl]propan-2-one at 0.01 mM
-
additional information
design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors, overview
-
additional information
design and synthesis of 2-oxoheterocycle inhibitors of fatty acid amide hydrolase, a 6-phenoxychroman-2-yl-2-ketooxazole series, and a 7-arylchroman-3-yl-2-ketooxazole series. Evaluation and role of conformational constraintsin the acyl side chain, overview
-
additional information
O-(triazolyl)methyl carbamates as potent fatty acid amide hydrolase inhibitors, overview. These compounds show improved stability in rat plasma and kinetic solubility in buffer with respect to the lead compound O-(1,2,3-triazol-4-yl)methyl carbamate
-
additional information
sulfonyl fluoride inhibitors of fatty acid amide hydrolase, structure-activity relationship, docking and molecular modeling, overview
-
additional information
structure-activity relationship studies on a series of aryl N-(omega-imidazolyl- and omega-tetrazolylalkyl)carbamate inhibitors are investigated. A pronounced increase in inhibitory potency is observed if a phenyl residue attached to the carbamate oxygen atom is replaced by a pyridin-3-yl moiety. The most active compounds exhibit IC50 values in the low nanomolar range. Investigations on the metabolic properties of these inhibitors are performed. In rat liver homogenate and in porcine plasma, the extent of their degradation is shown to be strongly dependent on the kind of aryl residue bound to the carbamate as well as on the length and type of the alkyl spacer connecting the carbamate group with the heterocyclic system
-
additional information
FAAH inhibition represents a promising strategy to activate the cannabinoid system, since it does not result in the psychotropic and peripheral side effects characterizing the agonists of the cannabinoid receptors
-
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0.000232
(1-benzothiophen-6-ylamino)([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)methanone
Homo sapiens
-
pH 8.4, 37°C
0.000237 - 0.000537
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
0.000089
(1H-benzo[d][1,2,3]triazol-1-yl)(4-(3-phenoxybenzyl)-piperazin-1-yl)-methanone
Homo sapiens
pH and temperature not specified in the publication
0.000708
(1H-benzo[d][1,2,3]triazol-1-yl)(4-(4-phenoxybenzyl)-piperazin-1-yl)-methanone hydrochloride
Homo sapiens
pH and temperature not specified in the publication
0.000015
(1H-imidazol-1-yl)(4-(3-phenoxybenzyl)piperazin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.0000034
(1H-imidazol-1-yl)(4-(4-phenoxy-benzyl)-piperazin-1-yl)-methanone hydrochloride
Homo sapiens
pH and temperature not specified in the publication
0.006
(2R)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.012
(2S)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.000023
(3H-[1,2,3]triazol[4,5-b]pyridin-3-yl)(4-(3-phenoxybenzyl)-piperazin-1-yl)-methanone
Homo sapiens
pH and temperature not specified in the publication
0.000005
(3R,4R)-4-acetoxy-3-((10R)-(t-butyldimethylsilyloxy)-ethyl)-azetidin-2-one
Homo sapiens
pH 7.4, 37°C
0.00162
(4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)-piperidin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.00037 - 0.00109
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
0.09
(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
Rattus norvegicus
-
37°C, substrate: anandamide
0.069
(5Z,8Z,11Z,14Z)-N-[(2R)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
Rattus norvegicus
-
37°C, substrate: anandamide
0.099
(5Z,8Z,11Z,14Z)-N-[(2S)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.000116
(dodecylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
Homo sapiens
-
pH 8.4, 37°C
0.05
(phenylamino)[[(4-phenylcyclohexylidene)amino]oxy]methanone
Homo sapiens
-
pH 8.4, 37°C
0.000008
(phenylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
Homo sapiens
-
pH 8.4, 37°C
0.0002
(phenylamino)[[(E)-[1-[4-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
Homo sapiens
-
pH 8.4, 37°C
0.26
(R,S)-ibuprofen
Rattus norvegicus
-
pH 7.4, 37°C
0.00782
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl 2-(biphenyl-4-yl)acetate
Homo sapiens
pH 7.4, 37°C
0.00805
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl 3-(1H-indol-3-yl)propanoate
Homo sapiens
pH 7.4, 37°C
0.00091
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl biphenyl-4-carboxylate
Homo sapiens
pH 7.4, 37°C
0.00503
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl-4-phenylbutanoate
Homo sapiens
pH 7.4, 37°C
0.001
([(E)-[1-(2,2'-bithiophen-5-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
Homo sapiens
-
pH 8.4, 37°C
0.001
([(E)-[1-(4-cyclohexylphenyl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
Homo sapiens
-
pH 8.4, 37°C
0.05
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(diphenylamino)methanone
Homo sapiens
-
pH 8.4, 37°C
0.00001
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
Homo sapiens
-
pH 8.4, 37°C
0.000069
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(phenylamino)methanone
Homo sapiens
-
pH 8.4, 37°C
0.00022
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(piperidin-1-yl)methanone
Homo sapiens
-
pH 8.4, 37°C
0.000017
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-fluorophenyl)amino]methanone
Homo sapiens
-
pH 8.4, 37°C
0.000028
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-methoxyphenyl)amino]methanone
Homo sapiens
-
pH 8.4, 37°C
0.0001
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(5-phenylpentyl)amino]methanone
Homo sapiens
-
pH 8.4, 37°C
0.05
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(dimethylamino)methanone
Homo sapiens
-
pH 8.4, 37°C
0.000401
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
Homo sapiens
-
pH 8.4, 37°C
0.00076
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(phenylamino)methanone
Homo sapiens
-
pH 8.4, 37°C
0.00000188
1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
Homo sapiens
pH and temperature not specified in the publication
0.00051 - 0.025
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
0.091
1,3-benzodioxol-5-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.00048
1-(1H-benzimidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000015
1-(1H-benzotriazol-1-yl)-3-(4-octylphenoxy)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000024
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
0.000011
1-(1H-benzotriazol-1-yl)-3-[(3'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000014
1-(1H-benzotriazol-1-yl)-3-[(3'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000021
1-(1H-benzotriazol-1-yl)-3-[(4'-chloro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000012
1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]butan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000012
1-(1H-benzotriazol-1-yl)-3-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0016
1-(1H-benzotriazol-1-yl)-3-[(4-phenoxyphenyl)thio]propan-2-one
Rattus norvegicus
pH and temperature not specified in the publication
0.000013
1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0018
1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]pentan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000012
1-(1H-benzotriazol-1-yl)-3-[([1,1'-biphenyl]-4-yl)oxy]propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00041
1-(1H-imidazol-1-yl)-3-(4-octylphenoxy)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00062
1-(1H-imidazo[4,5-b]pyridin-1-yl)-3-(4-octylphenoxy)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0023
1-(1H-indazol-1-yl)-3-(4-octylphenoxy)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0026
1-(1H-indazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0051
1-(2-oxo-3-[[4'-(propan-2-yl)biphenyl-4-yl]oxy]propyl)-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00041
1-(3H-imidazo[4,5-b]pyridin-3-yl)-3-(4-octylphenoxy)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000053
1-(4-octylphenoxy)-3-(1H-1,2,4-triazol-1-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00084
1-(4-octylphenoxy)-3-(1H-pyrazol-1-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0016
1-(4-octylphenoxy)-3-(1H-pyrazolo[3,4-b]pyridin-1-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000093
1-(4-octylphenoxy)-3-(1H-pyrazolo[4,3-b]pyridin-1-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000039
1-(4-octylphenoxy)-3-(1H-tetrazol-1-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000049
1-(4-octylphenoxy)-3-(1H-[1,2,3]triazolo[4,5-b]pyridin-1-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000112
1-(4-octylphenoxy)-3-(2H-1,2,3-triazol-2-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000013
1-(4-octylphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000013
1-(4-octylphenoxy)-3-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000008
1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00055
1-(5-nitro-1H-indazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0000029 - 0.000006
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
0.0000114
1-benzothiophen-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.00211 - 0.99146
1-[(3R)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
0.000028 - 0.0001
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
0.000031
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl (benzyloxy)acetate
Homo sapiens
pH 7.4, 37°C
0.00031
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 4-(pyridin-4-yl)butanoate
Homo sapiens
pH 7.4, 37°C
0.000012
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl biphenyl-4-ylacetate
Homo sapiens
pH 7.4, 37°C
0.000043
1-[([1,1'-biphenyl]-4-yl)oxy]-3-(1H-tetrazol-1-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0063
1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)butan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000011
1-[([1,1'-biphenyl]-4-yl)oxy]-3-(2H-tetrazol-2-yl)propan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000055
1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazole-5-carboxylic acid
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0012
1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0017
1-[2-oxo-3-[4-(2-phenoxyethoxy)phenoxy]propyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0029
1-[2-oxo-3-[4-(2-phenylpropan-2-yl)phenoxy]propyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0019
1-[3-(4-benzylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00016
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indazole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0064
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0023
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0016
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0034
1-[3-(biphenyl-3-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00046
1-[3-(biphenyl-4-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00023
1-[3-[(3'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00025
1-[3-[(3'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.005
1-[3-[(3-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00059
1-[3-[(3-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0074
1-[3-[(3-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000464 - 0.00503
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
0.00024
1-[3-[(4'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00053
1-[3-[(4'-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00058
1-[3-[(4'-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00009
1-[3-[4-(4-fluorophenyl)phenoxy]-2-oxopropyl]indazole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0026
1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0034
1-[3-[4-(heptyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0035
1-[3-[4-(hexyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0018
1-[3-[4-(nonyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0022
1-[3-[4-(octyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0017
1-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.016
1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.0017
1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.016
1-[4-(3-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.0017
1-[4-(4-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.017
1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.0045
1-[4-(4-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.0000075
1H-benzimidazol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000069
1H-indol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.00196
2,2,2-trichloroethyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate
Homo sapiens
pH and temperature not specified in the publication
0.098
2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.0000306
2,3-dihydro-1,4-benzodioxin-5-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.01
2-(1H-benzotriazol-1-yl)-1-(5-phenoxy-1,3-benzoxazol-2-yl)ethan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.017
2-(2-fluorobiphenyl-4-yl)-N-(2-(3-methylpyridin-2-ylamino)-2-oxoethyl)propanamide
Rattus norvegicus
pH 7.4, 37°C
0.00044
2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide
Rattus norvegicus
pH 7.4, 37°C
0.00065
2-(4-cyclohexylphenoxy)-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.047
2-(4-cyclohexylphenoxy)-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.0026
2-(4-cyclohexylphenoxy)-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.0015
2-(4-cyclohexylphenoxy)-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.00035
2-(4-cyclohexylphenoxy)-N-[4-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.021 - 0.099
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
0.00074
2-(6-methoxynaphthalen-2-yl)-N-(3-methylpyridin-2-yl)propanamide
Rattus norvegicus
pH 7.4, 37°C
0.00033
2-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0054
2-hydroxy-N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]acetamide
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0063
2-methoxy-N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]acetamide
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0018
2-methyl-N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0011
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.013
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.00063
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.00062
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.0047
2-[4-(2-methylpropyl)phenyl]-1-(4-phenylpiperazin-1-yl)propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.0052
2-[4-(2-methylpropyl)phenyl]-N-(3-methylpyridin-2-yl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.028
2-[4-(2-methylpropyl)phenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.051
2-[4-(2-methylpropyl)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.0055
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.073
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.017
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.064
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.00022
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000038
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
Homo sapiens
pH 9.0, 37°C
0.00006 - 0.000112
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
0.000084
3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide
Homo sapiens
-
pH 8.4, 37°C
0.00063
3-(1H-benzotriazol-1-yl)-1-[([1,1'-biphenyl]-4-yl)oxy]butan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000205
3-phenylpropane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.00000165 - 0.0000573
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
0.00531 - 0.0624
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
0.0297 - 0.5
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
0.000681 - 0.00654
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
0.14 - 0.193
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
0.000019
3-[([1,1'-biphenyl]-4-yl)oxy]-1-(1H-tetrazol-1-yl)butan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000009
3-[([1,1'-biphenyl]-4-yl)oxy]-1-(2H-tetrazol-2-yl)butan-2-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00000175
4-(3-phenoxybenzyl)-N-(4-methoxyphenyl)piperazine-1-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.00000199
4-(3-phenoxybenzyl)-N-(4-nitrophenyl)piperazine-1-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.00302
4-(3-phenoxybenzyl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000029 - 0.0000033
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.00001 - 0.000012
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
0.0000012
4-(4-benzyloxyphenoxy)butanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.00018
4-(acetylamino)phenyl (4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetate
Rattus norvegicus
-
pH 7.4, 37°C
0.0001
4-(acetylamino)phenyl 2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
Rattus norvegicus
-
pH 7.4, 37°C
0.058
4-(acetylamino)phenyl 2-[[2-(trifluoromethyl)pyridin-4-yl]amino]pyridine-3-carboxylate
Rattus norvegicus
-
pH 7.4, 37°C
0.0087
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.3
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylate
Rattus norvegicus
-
above, pH 7.4, 37°C
0.064
4-(acetylamino)phenyl 2-{[2-(trifluoromethyl)pyridin-4-yl]amino}benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.0015
4-(acetylamino)phenyl 3-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
Rattus norvegicus
-
pH 7.4, 37°C
0.0046
4-(acetylamino)phenyl 3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.047
4-(acetylamino)phenyl 3-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.022
4-(acetylamino)phenyl 4-([[2-(trifluoromethyl)pyridin-4-yl]amino]methyl)benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.031
4-(acetylamino)phenyl 4-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.0027
4-(acetylamino)phenyl 4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.0043
4-(acetylamino)phenyl 5-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.038
4-(acetylamino)phenyl 5-methyl-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.003
4-(acetylamino)phenyl N-(3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
Rattus norvegicus
-
pH 7.4, 37°C
0.00087
4-(acetylamino)phenyl N-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
Rattus norvegicus
-
pH 7.4, 37°C
0.0026
4-(acetylamino)phenyl N-[(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetyl]glycinate
Rattus norvegicus
-
pH 7.4, 37°C
0.00073
4-(acetylamino)phenyl N-[2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoyl]glycinate
Rattus norvegicus
-
pH 7.4, 37°C
0.000283
4-(benzyloxy)phenyl butylcarbamate
Homo sapiens
pH 9.0, 37°C
0.0000033
4-carbamoylnaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000045
4-fluoronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.00066
4-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0000062
4-hydroxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.000229
4-methoxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000053 - 0.00065
4-methoxyphenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
0.00000163
4-nitrophenyl-4-(4-phenoxy-benzyl)-piperazine-1-carboxylate
Homo sapiens
pH and temperature not specified in the publication
0.00194
4-nitrophenyl-4-(bis(benzo[d][1,3]dioxol-5-yl)methyl)piperidine-1-carboxylate
Homo sapiens
pH and temperature not specified in the publication
0.000088
4-phenylbutane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000034
4-[([4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamoyl)oxy]naphthalene-1-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000012 - 0.000028
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.000023 - 0.000034
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.000053
4-[3-[4-(decyloxy)phenoxy]-2-oxopropoxy]benzoic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000000072 - 0.0000012
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.00000043 - 0.00000046
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
0.0000022 - 0.00014
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.00000043 - 0.0000011
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.000000025 - 0.00000017
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.00000028 - 0.00000072
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.00000034 - 0.0000008
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.000013 - 0.000036
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.0000015 - 0.0000017
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.000244
5,6,7,8-tetrahydronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000015
5-(4-benzyloxyphenyl)pentanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000028 - 0.0000051
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
0.00005
5-phenylpentane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000005 - 0.000036
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
0.000038
6-phenylhexane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000043
7-(2-benzyloxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000012
7-(2-hydroxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000036
7-(3-benzyloxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000025
7-(3-hydroxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000269
7-(4-benzyloxyphenyl)heptane-1-sulfonic acid methyl ester
Rattus norvegicus
pH 7.4, 25°C
0.0000037
7-(4-benzyloxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000022
7-(4-hydroxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000206
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
Homo sapiens
pH 9.0, 37°C
0.000037
7-phenylheptane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000176
8-phenyloctane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000647 - 0.0111
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
0.00263 - 0.0988
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
0.011
benzol
Mus musculus
-
-
0.00195
benzyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)-piperidine-1-carboxylate
Homo sapiens
pH and temperature not specified in the publication
0.0000057
biphenyl-3-yl cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.00004 - 0.000056
chlorpyrifos oxon
0.0000012
decyl benzodioxaphosphorin oxide
Mus musculus
-
-
0.009
diazoxon
Mus musculus
-
-
0.0018
dichlorvos
Mus musculus
-
-
0.048
diisopropyl fluorophosphate
Mus musculus
-
-
0.0000005
dodecyl benzodioxaphosphorin oxide
Mus musculus
-
-
0.000002
dodecyl sulfonyl fluoride
Mus musculus
-
-
0.0000009 - 0.000005
dodecyl-benzodioxaphosphorin oxide
0.0000006 - 0.0000011
ethyl octylphosphonofluoridate
0.029
flurbiprofen
Rattus norvegicus
pH 7.4, 37°C
0.000126
heptyl benzodioxaphosphorin oxide
Mus musculus
-
-
0.000002
isopropyl dodecylfluorophosphate
Mus musculus
-
-
0.000001
JP104
Homo sapiens
pH 9.0, 37°C
0.000025
methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000001 - 0.000082
methyl arachidonyl phosphonofluoridate
0.0000001
methyl arachidonylfluoroposphate
Mus musculus
-
-
0.00000079
methyl octylphosphonofluoridate
Mus musculus
-
-
0.004
methyl [1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamate
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00541 - 0.5
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
0.00053
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0043
N-(1,4-dihydroquinolin-8-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.00074
N-(2-methylphenyl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0000013 - 0.0000017
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
0.00013
N-(3-bromopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.000058
N-(3-chloropyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.00013
N-(3-iodopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0091
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclobutane-1-carboxamide
Rattus norvegicus
37°C, pH 7.4
0.06
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopentane-1-carboxamide
Rattus norvegicus
37°C, pH 7.4
0.014
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopropane-1-carboxamide
Rattus norvegicus
37°C, pH 7.4
0.0013
N-(3-methylpyridin-2-yl)-2-(4'-isobutylphenyl)propionamide
Rattus norvegicus
-
pH 7.4, 37°C
0.048
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetamide
Rattus norvegicus
37°C, pH 7.4
0.00059
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0031
N-(3-methylpyridin-2-yl)-2-(4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.027
N-(3-methylpyridin-2-yl)-2-(4-[[8-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.004
N-(4-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.011
N-(5-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.025
N-(phenylcarbamoyl)-3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide
Homo sapiens
-
pH 8.4, 37°C
0.002
N-(pyrazin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.012
N-(pyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0064
N-(pyridin-3-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.052
N-(pyridin-4-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.00099
N-(pyrimidin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0047 - 0.027
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
0.00077 - 0.027
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
0.00209 - 0.242
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
0.0115 - 0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
0.000094 - 0.887
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
0.00453 - 0.0408
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
0.00084
N-cyclohexyl-N'-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]urea
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0016
N-ethyl-N'-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]urea
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00075
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000064
N-n-heptyl benzodioxaphosphorin oxide
Mus musculus
-
-
0.0000012 - 0.000011
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
0.5
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
0.021
N-[(2,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.0044
N-[(2,5-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.0041
N-[(2-chlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.018
N-[(2-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.036
N-[(3,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.018
N-[(3-hydroxy-4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.043
N-[(4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.023
N-[(pyridin-2-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.032
N-[(pyridin-3-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.006 - 0.021
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
0.0039
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]acetamide
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0024 - 0.027
N-[2-[(3-methylpyridin-2-yl)amino]-2-oxoethyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
0.00033
N-[3-(trifluoromethyl)pyridin-2-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.018
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-phenoxyacetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.0021
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-[4-(propan-2-yl)phenoxy]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.017
N-[4-(4-chlorophenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.000002 - 0.0000051
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
0.0000069
naphthalen-1-yl (3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propyl)carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000215
naphthalen-1-yl (4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]butyl)carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000062
naphthalen-1-yl [3-[4-(2,3-dichlorophenyl)piperazin-1-yl]propyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000064
naphthalen-1-yl [3-[4-(3-methoxyphenyl)piperazin-1-yl]propyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000053
naphthalen-1-yl [3-[4-(3-methylphenyl)piperazin-1-yl]propyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000486
naphthalen-1-yl [4-[4-(3-methoxyphenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.000013
naphthalen-1-yl [4-[4-(3-methylphenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.000073
O-n-octyl benzodioxaphosphorin oxide
Mus musculus
-
-
0.000024 - 0.000073
O-octyl-benzodioxaphosphorin oxide
0.000019
octyl sulfonyl fluoride
Mus musculus
-
-
0.000007 - 0.0000081
octyl-benzodioxaphosphorin oxide
0.0000134 - 0.000025
OL-135
0.0000243
oleoyl oxazolopyridine
Homo sapiens
-
recombinant enzyme, pH 7.3, 37°C
0.00000018 - 0.00000067
oleyl-benzodioxaphosphorin oxide
0.012 - 0.019
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
0.0082 - 0.028
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
0.011
oxiran-2-ylmethyl (9Z)-octadec-9-enoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.0016 - 0.05
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
0.061
oxiran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.035
oxiran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.00054 - 0.00077
paraoxon
0.00026
phenyl ([4-[(5-phenyl-2H-tetrazol-2-yl)methyl]phenyl]methyl)carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00987
phenyl 4-[(1H-indol-1-yl)methyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00011
phenyl 4-[2-(1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00011
phenyl 4-[2-(4-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00041
phenyl 4-[2-(5-chloro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00097
phenyl 4-[2-(5-cyano-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00013
phenyl 4-[2-(5-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00036
phenyl 4-[2-(5-methoxy-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00074
phenyl 4-[2-(5-methyl-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00081
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperazine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000046
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000052
phenyl 4-[2-(7-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00041
phenyl 4-[2-(9H-carbazol-9-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00057
phenyl 4-[3-(1H-indol-1-yl)propyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00018
phenyl 4-[4-(1H-indol-1-yl)butyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0021
phenyl [1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamate
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0052
phenyl [2-[2-(5-phenyl-2H-tetrazol-2-yl)ethoxy]ethyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00096
phenyl [4-(1H-indol-1-yl)butyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00000063
phenyl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.000094
phenyl [5-(1H-indol-1-yl)pentyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00043
phenyl [5-(2-phenyl-1H-imidazol-1-yl)pentyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00049
phenyl [5-(5-phenyl-2H-tetrazol-2-yl)pentyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.006
phenyl [6-(1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00025
phenyl [6-(1H-indol-1-yl)hexyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00047
phenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00029
phenyl [6-(2-phenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00049
phenyl [6-(4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00088
phenyl [6-(4-phenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00025
phenyl [6-(5-benzyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00048
phenyl [6-(5-phenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0013
phenyl [6-(5-phenyl-1H-tetrazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00062
phenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000054
phenyl [6-[2-(3-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000112
phenyl [6-[2-(3-fluorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00029
phenyl [6-[2-(3-methoxyphenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000075
phenyl [6-[2-(3-methylphenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00042
phenyl [6-[2-(4-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000209
phenyl [6-[5-(2-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00018
phenyl [6-[5-(3-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00057
phenyl [6-[5-(4-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00028
phenyl [6-[5-(pyridin-2-yl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00074
phenyl [6-[5-(pyridin-3-yl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0012
phenyl [6-[5-(pyridin-4-yl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000093
phenyl [7-(1H-indol-1-yl)heptyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00024
phenyl [7-(2-phenyl-1H-imidazol-1-yl)heptyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000081
phenyl [7-(5-phenyl-2H-tetrazol-2-yl)heptyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00024
phenyl [8-(1H-indol-1-yl)octyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0004
phenyl [8-(2-phenyl-1H-imidazol-1-yl)octyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000112
phenyl [8-(5-phenyl-2H-tetrazol-2-yl)octyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0089 - 0.011
phenyl-benzodioxaphosphorin oxide
0.000112
piperidin-1-yl[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
Homo sapiens
-
pH 8.4, 37°C
0.00015 - 0.00027
profenofos
0.00000442 - 0.0000573
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
0.000011
pyridin-3-yl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0000017
S-heptyl benzodioxaphosphorin oxide
Mus musculus
-
-
0.00000015
S-nonyl benzodioxaphosphorin oxide
Mus musculus
-
-
0.0000057
S-pentyl benzodioxaphosphorin oxide
Mus musculus
-
-
0.000131
stearyl benzodioxaphosphorin oxide
Mus musculus
-
-
0.026 - 0.051
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
0.029
tetrahydro-2H-pyran-2-ylmethyl (9Z)-octadec-9-enoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.0075
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.019
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.043
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.018
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.032 - 0.08
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
0.053
tetrahydro-2H-pyran-2-ylmethyl benzoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.000063
URB524
Rattus norvegicus
pH and temperature not specified in the publication
0.00136
URB532
Homo sapiens
pH 9.0, 37°C
0.000003 - 0.0000046
URB597
0.00007
[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
Rattus norvegicus
pH 9.0, 22°C
0.04252
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl (benzyloxy)acetate
Homo sapiens
pH 7.4, 37°C
0.08706
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl 4-(pyridin-2-yl)butanoate
Homo sapiens
pH 7.4, 37°C
0.173
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl 4-(pyridin-4-yl)butanoate
Homo sapiens
pH 7.4, 37°C
0.00005
[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
Rattus norvegicus
pH 9.0, 22°C
0.00009
[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
Rattus norvegicus
pH 9.0, 22°C
0.00046
[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
Rattus norvegicus
pH 9.0, 22°C
0.028
[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.017
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.002
[1-(2-naphthylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0053
[1-(4-phenoxyphenoxy)-3-(2H-tetrazol-2-yl)propan-2-yl]cyanamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0000245
[1-(m-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000215
[1-(o-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0005
[1-(p-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000119
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
0.0000062
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
0.0000195
[1-[(2-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000446
[1-[(2-fluoro-3-methoxy-phenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000099
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
0.0000014
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
0.000154
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Homo sapiens
pH 7.4, 37°C
0.0000032
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
0.0000076
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
0.0000104
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
0.0000036 - 0.0000105
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
0.0000132
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
0.0000215
[1-[(3-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000121
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
0.0000118
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
0.0000098
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
0.0000039
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
0.0000058
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
0.000215
[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.002282
[1-[(4-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000955
[1-[(4-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.000627
[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.132 - 0.5
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.0184 - 0.206
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.000471 - 0.00669
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.000713 - 0.00717
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.000556 - 0.00739
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.00542 - 0.0366
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.000375 - 0.00501
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.00399 - 0.0247
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
0.5
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
0.000505 - 0.00504
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
0.00682 - 0.531
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
0.00524 - 0.135
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
0.124 - 0.5
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
0.000161 - 0.0164
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
0.000854 - 0.0051
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
0.000388 - 0.00225
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
0.00288 - 0.037
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
0.00458 - 0.0286
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
0.000126 - 0.000423
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
0.00248 - 0.0279
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
0.000447
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00312 - 0.0705
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
0.00148 - 0.0174
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
0.000937 - 0.0096
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.5
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.042 - 0.5
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.000413 - 0.00332
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.000715 - 0.0829
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.001
[[(E)-[1-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]ethylidene]amino]oxy](naphthalen-1-ylamino)methanone
Homo sapiens
-
pH 8.4, 37°C
additional information
additional information
Mus musculus
-
pIC50, i.e. -log IC50. values of anadamide analogue inhibitors, overview
-
0.000237
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000537
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00037
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00109
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00051
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.025
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
Rattus norvegicus
37°C, pH 7.4
0.000024
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000024
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
Rattus norvegicus
pH and temperature not specified in the publication
0.0000029
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000006
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00211
1-[(3R)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH 8.0, 30°C, substrate: N-(6-methoxypyridin-3-yl)octanamide
0.99146
1-[(3R)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH 8.0, 30°C, substrate: N-(6-methoxypyridin-3-yl)decanamide
0.000028
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
pH and temperature not specified in the publication
0.0001
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Rattus norvegicus
pH and temperature not specified in the publication
0.000464
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00053
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00503
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.021
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.099
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.00006
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00006
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0000884
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
Homo sapiens
-
pH 8.0, 30°C, substrate: N-(6-methoxypyridin-3-yl)octanamide
0.000112
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000112
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
Homo sapiens
-
pH 8.0, 30°C, substrate: N-(6-methoxypyridin-3-yl)decanamide
0.00000165
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Homo sapiens
pH 8.0, 37°C, mutant enzyme P129T
0.00000399
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Homo sapiens
pH 8.0, 37°C, wild-type enzyme
0.00000442
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Rattus norvegicus
pH 8.0, 37°C, wild-type enzyme
0.0000573
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Homo sapiens
pH 8.0, 37°C, wild-type enzyme
0.00531
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0624
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0297
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
Homo sapiens
-
above, pH and temperature not specified in the publication
0.000681
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00654
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.14
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.193
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000029
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.0000033
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00001
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
Rattus norvegicus
-
JNJ-1661010, without preincubation
0.000012
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
Homo sapiens
JNJ-1661010, without preincubation
0.0000053
4-methoxyphenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00065
4-methoxyphenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000012
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.000028
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.000023
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.000034
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.000000072
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.0000012
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00000043
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.00000046
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000022
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.0000043
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.000074
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00014
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.00000043
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000011
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.000000025
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.00000017
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00000028
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00000072
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.00000034
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000008
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.000013
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.000036
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.0000015
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.0000017
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000028
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000051
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
Homo sapiens
pH 7.4, 25°C
0.000005
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000036
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
pH and temperature not specified in the publication
0.000647
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0111
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00263
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0988
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00004
chlorpyrifos oxon
Mus musculus
-
-
0.00004
chlorpyrifos oxon
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.000056
chlorpyrifos oxon
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.029
DFP
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.048
DFP
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.0000009
dodecyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.000005
dodecyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.0000006
ethyl octylphosphonofluoridate
Mus musculus
-
-
0.0000006
ethyl octylphosphonofluoridate
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.0000011
ethyl octylphosphonofluoridate
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.0000001
methyl arachidonyl phosphonofluoridate
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.000082
methyl arachidonyl phosphonofluoridate
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.00541
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
Homo sapiens
-
above, pH and temperature not specified in the publication
0.0000013
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000017
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.0047
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.027
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
Rattus norvegicus
37°C, pH 7.4
0.00077
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.027
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
Rattus norvegicus
37°C, pH 7.4
0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
Homo sapiens
-
above, pH and temperature not specified in the publication
0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.00209
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.242
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
Homo sapiens
-
above, pH and temperature not specified in the publication
0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.0115
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
Homo sapiens
-
above, pH and temperature not specified in the publication
0.000094
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.887
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00453
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0408
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000012
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.000011
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
Homo sapiens
pH 9.0, 37°C
0.5
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
Homo sapiens
-
above, pH and temperature not specified in the publication
0.5
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.006
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
Homo sapiens
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.021
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
Rattus norvegicus
37°C, pH 7.4
0.0024
N-[2-[(3-methylpyridin-2-yl)amino]-2-oxoethyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.027
N-[2-[(3-methylpyridin-2-yl)amino]-2-oxoethyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.000002
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
Homo sapiens
-
pH 8.0, 22°C, at 78 nM substrate anandamide
0.000002
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
Rattus norvegicus
-
pH 8.0, 22°C, at 78 nM substrate anandamide
0.0000038
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
Homo sapiens
-
pH 8.0, 22°C, at 0.01 mM substrate anandamide
0.0000038
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
Rattus norvegicus
-
pH 8.0, 22°C, at 0.01 mM substrate anandamide
0.0000051
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
Homo sapiens
-
pH 8.0, 22°C, at 0.005 mM substrate anandamide
0.0000051
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
Rattus norvegicus
-
pH 8.0, 22°C, at 0.005 mM substrate anandamide
0.000024
O-octyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.000073
O-octyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.000007
octyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.0000081
octyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.0000134
OL-135
Homo sapiens
pH 9.0, 37°C
0.000016
OL-135
Homo sapiens
pH and temperature not specified in the publication
0.000025
OL-135
Rattus norvegicus
pH and temperature not specified in the publication
0.00000018
oleyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.00000067
oleyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.012
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.019
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.0082
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.028
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.0016
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.05
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.00054
paraoxon
Mus musculus
-
-
0.00054
paraoxon
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.00077
paraoxon
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.0089
phenyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.011
phenyl-benzodioxaphosphorin oxide
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.00015
profenofos
Mus musculus
-
25°C, pH 9.0, liver enzyme
0.00027
profenofos
Mus musculus
-
25°C, pH 9.0, brain enzyme
0.00000442
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 8.0
0.0000573
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Homo sapiens
37°C, pH 8.0
0.026
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.051
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.032
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.08
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.000003
URB597
Rattus norvegicus
pH and temperature not specified in the publication
0.000004
URB597
Homo sapiens
pH and temperature not specified in the publication
0.0000046
URB597
Rattus norvegicus
pH and temperature not specified in the publication
0.0000119
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000119
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000062
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000062
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000099
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000099
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000014
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000014
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000032
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000032
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Homo sapiens
pH 7.4, 37°C
0.0000076
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000076
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Homo sapiens
pH 7.4, 37°C
0.0000104
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000104
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000036
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000105
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000132
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000132
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000121
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000121
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000118
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000118
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Homo sapiens
pH 7.4, 37°C
0.0000098
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000098
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Homo sapiens
pH 7.4, 37°C
0.0000039
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000039
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Homo sapiens
pH 7.4, 37°C
0.0000058
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000058
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Homo sapiens
pH 7.4, 37°C
0.132
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
above, pH and temperature not specified in the publication
0.5
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.0184
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.206
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000471
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00669
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000713
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00717
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000556
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00739
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00542
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0366
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000375
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00501
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00399
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0247
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.5
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
Homo sapiens
-
above, pH and temperature not specified in the publication
0.5
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.000505
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00504
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00682
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.531
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00524
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.135
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.124
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
Homo sapiens
-
above, pH and temperature not specified in the publication
0.000161
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0164
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000854
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0051
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000388
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00225
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00288
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.037
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00458
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0286
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000126
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000423
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00248
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0279
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00312
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0705
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00148
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0174
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000937
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0096
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.5
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
above, pH and temperature not specified in the publication
0.5
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.042
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
above, pH and temperature not specified in the publication
0.000413
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00332
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000715
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00364
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00809
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.0829
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
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Patricelli, M.P.; Lashuel, H.A.; Giang, D.K.; Kelly, J.W.; Cravatt, B.F.
Comparative characterization of wild type and transmembrane domain-deleted fatty acid amide hydrolase identification of the transmembrane domain as a site for oligomerization
Biochemistry
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1998
Rattus norvegicus
brenda
Vandevoorde, S.; Fowler, C.J.
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2005
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Quistad, G.B.; Klintenberg, R.; Caboni, P.; Liang, S.N.; Casida, J.E.
Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice
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211
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2006
Mus musculus
brenda
Cisneros, J.A.; Vandevoorde, S.; Ortega-Gutierrez, S.; Paris, C.; Fowler, C.J.; Lopez-Rodriguez, M.L.
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2007
Rattus norvegicus
brenda
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Mus musculus
brenda
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A second fatty acid amide hydrolase with variable distribution among placental mammals
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2006
Homo sapiens (O00519), Homo sapiens (Q6GMR7), Homo sapiens, Mus musculus (O08914), Mus musculus, Rattus norvegicus (P97612)
brenda
Fowler, C.J.; Jonsson, K.O.; Tiger, G.
Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide
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2001
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
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Patricelli, M.P.; Cravatt, B.F.
Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism
Biochemistry
38
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1999
Rattus norvegicus
brenda
Patricelli M.P.; Lovato, M.A.; Cravatt, B.F.
Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties
Biochemistry
38
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1999
Rattus norvegicus
brenda
Patricelli, M.P.; Cravatt, B.F.
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase
Biochemistry
40
6107-6115
2001
Rattus norvegicus
brenda
Ferreri, C.; Anagnostopoulos, D.; Lykakis, I.N.; Chatgilialoglu, C.; Siafaka-Kapadai, A.
Synthesis of all-trans anandamide: A substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation
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16
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2008
Oryctolagus cuniculus
brenda
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Fatty acid amide hydrolase substrate specificity
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2000
Rattus norvegicus
brenda
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QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation
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2005
Rattus norvegicus
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Clarifying the catalytic roles of conserved residues in the amidase signature family
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275
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2000
Rattus norvegicus
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42
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1999
Rattus norvegicus
brenda
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Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase
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2007
Rattus norvegicus
brenda
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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Nature
384
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1996
Rattus norvegicus
brenda
Egertova, M.; Cravatt, B.F.; Elphick, M.R.
Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide
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2000
Rattus norvegicus
brenda
Giang, D.K.; Cravatt, B.F.
Molecular characterization of human and mouse fatty acid amide hydrolases
Proc. Natl. Acad. Sci. USA
94
2238-2242
1997
Rattus norvegicus, Homo sapiens (O00519), Homo sapiens, Mus musculus (O08914), Mus musculus
brenda
Boger, D.L.; Sato, H.; Lerner, A.E.; Hedrick, M.P.; Fecik, R.A.; Miyauchi, H.; Wilkie, G.D.; Austin, B.J.; Patricelli, M.P.; Cravatt, B.F.
Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide
Proc. Natl. Acad. Sci. USA
97
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2000
Homo sapiens, Rattus norvegicus
brenda
Bracey, M.H.; Hanson, M.A.; Masuda, K.R.; Stevens, R.C.; Cravatt, B.F.
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling.
Science
298
1793-1796
2002
Rattus norvegicus (P97612)
brenda
Quistad, G.B.; Sparks, S.E.; Casida, J.E.
Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides
Toxicol. Appl. Pharmacol.
173
48-55
2001
Mus musculus
brenda
Karbarz, M.J.; Luo, L.; Chang, L.; Tham, C.S.; Palmer, J.A.; Wilson, S.J.; Wennerholm, M.L.; Brown, S.M.; Scott, B.P.; Apodaca, R.L.; Keith, J.M.; Wu, J.; Breitenbucher, J.G.; Chaplan, S.R.; Webb, M.
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase
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108
316-329
2009
Rattus norvegicus, Homo sapiens (Q6GMR7), Homo sapiens
brenda
Kaczocha, M.; Glaser, S.T.; Chae, J.; Brown, D.A.; Deutsch, D.G.
Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2
J. Biol. Chem.
285
2796-2806
2010
Homo sapiens
brenda
Wyffels, L.; Muccioli, G.G.; De Bruyne, S.; Moerman, L.; Sambre, J.; Lambert, D.M.; De Vos, F.
Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain
J. Med. Chem.
52
4613-4622
2009
Mus musculus
brenda
Onnis, V.; Congiu, C.; Bjoerklund, E.; Hempel, F.; Soederstroem, E.; Fowler, C.J.
Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors
J. Med. Chem.
53
2286-2298
2010
Rattus norvegicus
brenda
Lever, I.J.; Robinson, M.; Cibelli, M.; Paule, C.; Santha, P.; Yee, L.; Hunt, S.P.; Cravatt, B.F.; Elphick, M.R.; Nagy, I.; Rice, A.S.
Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury
J. Neurosci.
29
3766-3780
2009
Rattus norvegicus
brenda
Naidu, P.S.; Kinsey, S.G.; Guo, T.L.; Cravatt, B.F.; Lichtman, A.H.
Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase
J. Pharmacol. Exp. Ther.
334
182-190
2010
Mus musculus
brenda
Glaser, S.T.; Kaczocha, M.
Temporal changes in mouse brain fatty acid amide hydrolase activity
Neuroscience
163
594-600
2009
Mus musculus
brenda
Rakers, C.; Zoerner, A.A.; Engeli, S.; Batkai, S.; Jordan, J.; Tsikas, D.
Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity
Anal. Biochem.
421
699-705
2012
Canis lupus familiaris, Homo sapiens
brenda
Tian, G.; Paschetto, K.A.; Gharahdaghi, F.; Gordon, E.; Wilkins, D.E.; Luo, X.; Scott, C.W.
Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency
Biochemistry
50
6867-6878
2011
Homo sapiens, Rattus norvegicus
brenda
Gattinoni, S.; Simone, C.D.; Dallavalle, S.; Fezza, F.; Nannei, R.; Battista, N.; Minetti, P.; Quattrociocchi, G.; Caprioli, A.; Borsini, F.; Cabri, W.; Penco, S.; Merlini, L.; Maccarrone, M.
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase
Bioorg. Med. Chem. Lett.
20
4406-4411
2010
Homo sapiens
brenda
Roughley, S.D.; Browne, H.; Macias, A.T.; Benwell, K.; Brooks, T.; D'Alessandro, J.; Daniels, Z.; Dugdale, S.; Francis, G.; Gibbons, B.; Hart, T.; Haymes, T.; Kennett, G.; Lightowler, S.; Matassova, N.; Mansell, H.; Merrett, A.; Misra, A.; Padfield, A.; Parsons, R.; Pratt, R.; Robertson, A.; Simmonite, H.; Tan, K.; Walls, S.B.; Wong, M.
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity
Bioorg. Med. Chem. Lett.
22
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2012
Homo sapiens, Rattus norvegicus
brenda
Zahov, S.; Drews, A.; Hess, M.; Schulze Elfringhoff, A.; Lehr, M.
1-(3-biaryloxy-2-oxopropyl)indole-5-carboxylic acids and related compounds as dual inhibitors of human cytosolic phospholipase A2alpha and fatty acid amide hydrolase
ChemMedChem
6
544-549
2011
Homo sapiens, Rattus norvegicus
brenda
Strittmatter, F.; Gandaglia, G.; Benigni, F.; Bettiga, A.; Rigatti, P.; Montorsi, F.; Gratzke, C.; Stief, C.; Colciago, G.; Hedlund, P.
Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats
Eur. Urol.
61
98-106
2012
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Mukhopadhyay, P.; Horvath, B.; Rajesh, M.; Matsumoto, S.; Saito, K.; Batkai, S.; Patel, V.; Tanchian, G.; Gao, R.Y.; Cravatt, B.F.; Hasko, G.; Pacher, P.
Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury
Free Radic. Biol. Med.
50
179-195
2011
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
brenda
Teaster, N.D.; Keereetaweep, J.; Kilaru, A.; Wang, Y.S.; Tang, Y.; Tran, C.N.; Ayre, B.G.; Chapman, K.D.; Blancaflor, E.B.
Overexpression of fatty acid amide hydrolase induces early flowering in Arabidopsis thaliana
Front. Plant Sci.
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32
2012
Arabidopsis thaliana (Q7XJJ7), Arabidopsis thaliana
brenda
Long, J.Z.; LaCava, M.; Jin, X.; Cravatt, B.F.
An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase
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52
337-344
2011
Mus musculus
brenda
Mileni, M.; Kamtekar, S.; Wood, D.C.; Benson, T.E.; Cravatt, B.F.; Stevens, R.C.
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation
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400
743-754
2010
Rattus norvegicus (P97612)
brenda
Bouskila, J.; Burke, M.W.; Zabouri, N.; Casanova, C.; Ptito, M.; Bouchard, J.F.
Expression and localization of the cannabinoid receptor type 1 and the enzyme fatty acid amide hydrolase in the retina of vervet monkeys
Neuroscience
202
117-130
2012
Chlorocebus sabaeus
brenda
Min, X.; Thibault, S.T.; Porter, A.C.; Gustin, D.J.; Carlson, T.J.; Xu, H.; Lindstrom, M.; Xu, G.; Uyeda, C.; Ma, Z.; Li, Y.; Kayser, F.; Walker, N.P.; Wang, Z.
Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)
Proc. Natl. Acad. Sci. USA
108
7379-7384
2011
Homo sapiens (O00519), Rattus norvegicus (P97612)
brenda
Kono, M.; Matsumoto, T.; Imaeda, T.; Kawamura, T.; Fujimoto, S.; Kosugi, Y.; Odani, T.; Shimizu, Y.; Matsui, H.; Shimojo, M.; Kori, M.
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors
Bioorg. Med. Chem.
22
1468-1478
2014
Homo sapiens (O00519), Rattus norvegicus (P97612), Rattus norvegicus Sprague-Dawley (P97612)
brenda
Duncan, K.K.; Otrubova, K.; Boger, D.L.
alpa-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain
Bioorg. Med. Chem.
22
2763-2770
2014
Rattus norvegicus (P97612)
brenda
Korhonen, J.; Kuusisto, A.; van Bruchem, J.; Patel, J.Z.; Laitinen, T.; Navia-Paldanius, D.; Laitinen, J.T.; Savinainen, J.R.; Parkkari, T.; Nevalainen, T.J.
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)
Bioorg. Med. Chem.
22
6694-6705
2014
Homo sapiens (O00519)
brenda
Colombano, G.; Albani, C.; Ottonello, G.; Ribeiro, A.; Scarpelli, R.; Tarozzo, G.; Daglian, J.; Jung, K.M.; Piomelli, D.; Bandiera, T.
O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors
ChemMedChem
10
380-395
2015
Homo sapiens (O00519), Homo sapiens, Rattus norvegicus (P97612), Rattus norvegicus SpragueDawley (P97612)
brenda
Cipriano, M.; Bjoerklund, E.; Wilson, A.A.; Congiu, C.; Onnis, V.; Fowler, C.J.
Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen
Eur. J. Pharmacol.
720
383-390
2013
Rattus norvegicus (P97612)
brenda
Caruano, J.; Feledziak, M.; Labar, G.; Michaux, C.; Perpete, E.A.; Muccioli, G.G.; Robiette, R.; Marchand-Brynaert, J.
(S)-1-(Pent-4-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling
J. Enzyme Inhib. Med. Chem.
29
654-662
2014
Homo sapiens (O00519), Homo sapiens
brenda
Alapafuja, S.O.; Nikas, S.P.; Bharathan, I.T.; Shukla, V.G.; Nasr, M.L.; Bowman, A.L.; Zvonok, N.; Li, J.; Shi, X.; Engen, J.R.; Makriyannis, A.
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase
J. Med. Chem.
55
10074-10089
2012
Homo sapiens (O00519), Homo sapiens, Rattus norvegicus (P97612)
brenda
Dato, F.M.; Maassen, A.; Goldfuss, B.; Pietsch, M.
Characterization of fatty acid amide hydrolase activity by a fluorescence-based assay
Anal. Biochem.
546
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2018
Homo sapiens
brenda
Sundermann, T.; Fabian, J.; Hanekamp, W.; Lehr, M.
1-Heteroaryl-3-phenoxypropan-2-ones as inhibitors of cytosolic phospholipase A2alpha and fatty acid amide hydrolase Effect of the replacement of the ether oxygen with sulfur and nitrogen moieties on enzyme inhibition and metabolic stability
Bioorg. Med. Chem.
23
2579-2592
2015
Rattus norvegicus (P97612)
brenda
Zahov, S.; Garzinsky, D.; Hanekamp, W.; Lehr, M.
1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase Studies on structure-activity relationships and metabolic stability
Bioorg. Med. Chem.
25
825-837
2017
Homo sapiens
brenda
Terwege, T.; Hanekamp, W.; Garzinsky, D.; Koenig, S.; Koch, O.; Lehr, M.
omega-Imidazolyl- and omega-tetrazolylalkylcarbamates as inhibitors of fatty acid amide hydrolase Biological activity and in vitro metabolic stability
ChemMedChem
11
429-443
2016
Rattus norvegicus (P97612)
brenda
Deplano, A.; Morgillo, C.M.; Demurtas, M.; Bjoerklund, E.; Cipriano, M.; Svensson, M.; Hashemian, S.; Smaldone, G.; Pedone, E.; Luque, F.J.; Cabiddu, M.G.; Novellino, E.; Fowler, C.J.; Catalanotti, B.; Onnis, V.
Novel propanamides as fatty acid amide hydrolase inhibitors
Eur. J. Med. Chem.
136
523-542
2017
Rattus norvegicus (P97612)
brenda
Watabiki, T.; Tsuji, N.; Kiso, T.; Ozawa, T.; Narazaki, F.; Kakimoto, S.
In vitro and in vivo pharmacological characterization of ASP8477 A novel highly selective fatty acid amide hydrolase inhibitor
Eur. J. Pharmacol.
815
42-48
2017
Homo sapiens (B2C6G4), Homo sapiens (O00519), Homo sapiens, Rattus norvegicus (P97612)
brenda
Giacovazzo, G.; Bisogno, T.; Piscitelli, F.; Verde, R.; Oddi, S.; Maccarrone, M.; Coccurello, R.
Different routes to inhibit fatty acid amide hydrolase do all roads lead to the same place?
Int. J. Mol. Sci.
20
E4503
2019
Mus musculus (O08914)
brenda
Althaus, J.; Hake, T.; Hanekamp, W.; Lehr, M.
1-(5-Carboxyindazol-1-yl)propan-2-ones as dual inhibitors of cytosolic phospholipase A2? and fatty acid amide hydrolase bioisosteric replacement of the carboxylic acid moiety
J. Enzyme Inhib. Med. Chem.
31
131-140
2016
Homo sapiens
brenda
Sundermann, T.; Hanekamp, W.; Lehr, M.
Structure-activity relationship studies on 1-heteroaryl-3-phenoxypropan-2-ones acting as inhibitors of cytosolic phospholipase A2alpha and fatty acid amide hydrolase replacement of the activated ketone group by other serine traps
J. Enzyme Inhib. Med. Chem.
31
653-663
2016
Homo sapiens
brenda
Sunduru, N.; Svensson, M.; Cipriano, M.; Marwaha, S.; Andersson, C.D.; Svensson, R.; Fowler, C.J.; Elofsson, M.
N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors
J. Enzyme Inhib. Med. Chem.
32
513-521
2017
Rattus norvegicus (P97612)
brenda
Deplano, A.; Cipriano, M.; Moraca, F.; Novellino, E.; Catalanotti, B.; Fowler, C.J.; Onnis, V.
Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors
J. Enzyme Inhib. Med. Chem.
34
562-576
2019
Rattus norvegicus (P97612)
brenda
Micoli, A.; De Simone, A.; Russo, D.; Ottonello, G.; Colombano, G.; Ruda, G.; Bandiera, T.; Cavalli, A.; Bottegoni, G.
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl]carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase
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537-541
2016
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Dahlhaus, H.; Hanekamp, W.; Lehr, M.
(Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH)
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2017
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